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References from Synergistic cytotoxicity of tannic acid from Phyllanthus emblica and cisplatin in U2OS osteosarcoma cells: Surface ultramorphology and apoptotic gene modulation. Local targets link to admitted publications; unresolved targets remain external evidence.
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2019 · External reference
Berberine and cisplatin exhibit synergistic anticancer effects on osteosarcoma MG-63 cells by inhibiting the MAPK pathway
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p27, the cell cycle and Alzheimer´s disease
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Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria-mediated apoptosis
2019 · External reference
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ERK/MAPK signalling pathway and tumorigenesis
2020 · External reference
Caspase-8: arbitrating life and death in the innate immune system
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Exploring apoptotic pathways: implications for cancer, inflammation, and neurodegeneration
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Both JNK1 and JNK2 are indispensable for sensitized extracellular matrix mineralization in IKKβ-deficient osteoblasts
2020 · External reference
Nanoparticle-driven reactive oxygen species therapy: a new frontier in osteosarcoma treatment
10.1016/j.jconrel.2025.114289 · 2025 · External reference
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The multifaceted role of tannic acid: from its extraction and structure to antibacterial properties and applications
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EGCG regulated osteolytic microenvironment to enhance the antitumor effect of DOX on orthotopic osteosarcoma
10.1016/j.jff.2022.105118 · 2022 · External reference
The regulatory networks and mechanisms of bone microenvironment in tumorigenesis and metastasis
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Apoptosis regulators Bcl-2 and Caspase-3
10.3390/encyclopedia2040111 · 2022 · External reference
TRAF3/p38-JNK signalling crosstalk with intracellular-TRAIL/caspase-10-induced apoptosis accelerates ROS-driven cancer cell-specific death by CD40
10.3390/cells11203274 · 2022 · External reference
New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration
2018 · External reference
Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy
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Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway
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Pharmacological effects and mechanisms of tannic acid
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Apoptosis markers in breast cancer therapy
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Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma
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Tannic acid enhances cisplatin effect on cell proliferation and apoptosis of human osteosarcoma cell line (U2OS)
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Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells
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Regulation of DNA fragmentation: the role of caspases and phosphorylation
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2026 · External reference
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10.1038/nrm3861 · 2014 · External reference
Onosma bracteata Wall. induces G0/G1 arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT/GSK3β/cyclin E pathway
10.1007/s11356-020-11466-9 · 2021 · External reference
Antioxidant phytoconstituents from Onosma bracteata Wall. (Boraginaceae) ameliorate the CCl(4) induced hepatic damage: in vivo study in male wistar rats
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Curcumin ameliorates cisplatin-induced nephrotoxicity and potentiates its anticancer activity in SD rats: potential role of curcumin in breast cancer chemotherapy
10.3389/fphar.2017.00132 · 2017 · External reference
Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis
2024 · External reference
RNA quality score evaluation: a preliminary study of RNA integrity number (RIN) and RNA integrity and quality number (RNA IQ)
10.1016/j.forsciint.2024.111976 · 2024 · External reference
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma
10.1038/s41392-025-02250-7 · 2025 · External reference
The role of programmed cell death in osteosarcoma: from pathogenesis to therapy
10.1002/cam4.7303 · 2024 · External reference
The role of programmed cell death in osteosarcoma: from pathogenesis to therapy
10.1002/cam4.7303 · 2024 · External reference
Lycorine combined with cisplatin synergistically inhibited osteosarcoma cells growth and metastasis by suppressing Wnt/β-Catenin and STAT3 signaling pathways
10.1016/j.jff.2024.106339 · 2024 · External reference
Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways
10.1248/bpb.b12-00197 · 2012 · External reference
Formononetin enhances cisplatin chemotherapy sensitivity in osteosarcoma by inducing ferroptosis and reconstructing the immune microenvironment
10.1016/j.phymed.2025.156960 · 2025 · External reference
Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death
10.1016/j.yexcr.2004.05.006 · 2004 · External reference
Tannic acid-induced apoptosis in FaDu hypopharyngeal squamous cell carcinoma
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Interplay between cell death and cell proliferation reveals new strategies for cancer therapy
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Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer
2025 · External reference
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway
10.1016/j.phymed.2020.153186 · 2020 · External reference
Simple and affordable synchronous spectrofluorimetric determination of the natural anticancer polyphenols; resveratrol and curcumin in human plasma
10.1016/j.saa.2023.123029 · 2023 · External reference
Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice
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c-Jun N-terminal kinase (JNK), p38, and caspases: promising therapeutic targets for the regulation of apoptosis in cancer cells by phytochemicals
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ERK1/2-MAPK signaling: metabolic, organellar, and cytoskeletal interactions
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Sustainable healing: natural compounds facilitating the future cancer treatment
10.1016/j.wds.2025.100215 · 2025 · External reference
The apoptosis paradox in cancer
10.3390/ijms23031328 · 2022 · External reference
Systemic strategies for osteosarcoma: advances and future directions
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Geometric analysis of structural changes in microscopic nuclei images for drug-induced cytotoxic assessment
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Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications
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Targeting signaling cascades by bioactive phytocompounds in osteosarcoma: A novel therapeutic approach
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Apoptotic signaling: beyond cell death
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External reference
Evaluation of caspase-3 activity during apoptosis with fluorescence lifetime-based cytometry measurements and phasor analyses
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Multiple roles of caspase-8 in cell death, inflammation, and innate immunity
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Anti-tumour potential and selectivity of caffeic acid phenethyl ester in osteosarcoma cells
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trans-anethole abrogates cell proliferation and induces apoptosis through the mitochondrial-mediated pathway in human osteosarcoma cells
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Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts
2004 · External reference
Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
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Probing the protrusions: lamellipodia and filopodia in cancer invasion and beyond
2024 · External reference
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Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma
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LukS-PV induces cell cycle arrest and apoptosis through p38/ERK MAPK signaling pathway in NSCLC cells
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Overview of biodegradable materials for bone repair and osteosarcoma treatment: from bulk to scaffolds
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Cisplatin toxicity is counteracted by the activation of the p38/ATF-7 signaling pathway in post-mitotic C. elegans
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p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice
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Chapter 1 - Insight on the role of RKIP in cancer through key protein partners and cellular protrusions
2020 · External reference
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Chapter 17 - Scanning electron microscope
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Investigating the cellular responses of osteosarcoma to cisplatin by confocal Raman microspectroscopy
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Nanodrugs based on co-delivery strategies to combat cisplatin resistance
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Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway
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Magnoflorine inhibits the malignant phenotypes and increases cisplatin sensitivity of osteosarcoma cells via regulating miR-410-3p/HMGB1/NF-kappaB pathway
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External reference
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Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells
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Plant derived tannic acid-based tissue adhesives: from mechanism to advanced design
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Rhizoma Paridis saponins suppresses vasculogenic mimicry formation and metastasis in osteosarcoma through regulating miR-520d-3p/MIG-7 axis
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Oleandrin synergizes with cisplatin in human osteosarcoma cells by enhancing cell apoptosis through activation of the p38 MAPK signaling pathway
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Recent advances in tannic acid (Gallotannin) anticancer activities and drug delivery systems for efficacy improvement; a comprehensive review
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Tumor microenvironment in osteosarcoma: from cellular mechanism to clinical therapy
2025 · External reference
Understanding MAPK signaling pathways in apoptosis
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Tannic acid mediated induction of apoptosis in human glioma Hs 683 cells
2018 · External reference
Caspase-8 in inflammatory diseases: a potential therapeutic target
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