References

Farnesoid X receptor ligand prevents cisplatin-induced kidney injury by enhancing small heterodimer partner

10.1371/journal.pone.0086553 · 2014 · External reference

Predictive value of precision-cut kidney slices as an ex vivo screening platform for therapeutics in human renal fibrosis

10.3390/pharmaceutics12050459 · 2020 · External reference

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

10.1016/j.cell.2006.06.049 · 2006 · External reference

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

10.1152/ajpgi.00539.2005 · 2006 · External reference

Yinchenhao decoction alleviates liver fibrosis by regulating bile acid metabolism and TGF-β/Smad/ERK signalling pathway

10.1038/s41598-018-33669-4 · 2018 · External reference

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter

10.1074/jbc.m207903200 · 2003 · External reference

Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021

10.1186/s12889-025-21851-z · 2025 · External reference

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes

10.1002/hep.20942 · 2005 · External reference

Bile acid physiology

10.5604/01.3001.0010.5493 · 2017 · External reference

Chapter 6 - quality control for RNA preparations

2017 · External reference

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage

10.1038/s41598-017-10168-6 · 2017 · External reference

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

10.1016/s1097-2765(00)00051-4 · 2000 · External reference

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

10.1016/j.cmet.2005.09.001 · 2005 · External reference

Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid

10.1111/j.1476-5381.2012.02117.x · 2012 · External reference

Standardized protocol for the preparation of precision-cut kidney slices: a translational model of renal fibrosis

10.1007/978-1-0716-3179-9_9 · 2023 · External reference

Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices

10.1111/apha.13291 · 2019 · External reference

The effects of bile acids on freshly isolated rat glomeruli and proximal tubular fragments

10.1016/s0887-2333(97)00092-1 · 1997 · External reference

A G protein-coupled receptor responsive to bile acids

10.1074/jbc.m209706200 · 2003 · External reference

Expression and function of the bile acid receptor TGR5 in Kupffer cells

10.1016/j.bbrc.2008.04.171 · 2008 · External reference

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis

10.1096/fj.201900325r · 2019 · External reference

The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD

10.1038/s41419-021-03620-z · 2021 · External reference

EP1 receptor antagonism mitigates early and late stage renal fibrosis

10.1111/apha.13780 · 2022 · External reference

Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway

10.1152/ajpendo.00248.2024 · 2025 · External reference

Activation of TGR5 alleviates renal fibrosis by promoting NEDD4L-mediated p-Smad2/3 ubiquitination

10.1111/apha.70163 · 2026 · External reference

The farnesoid X receptor agonist EDP-305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction

10.1096/fj.201801699r · 2019 · External reference

Nuclear receptors in bile acid metabolism

10.3109/03602532.2012.740048 · 2013 · External reference

Hirudin, a thrombin inhibitor, attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling

2022 · External reference

Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation

10.1016/j.cellsig.2014.05.018 · 2014 · External reference

Cellular and molecular mechanisms of renal fibrosis

10.1038/nrneph.2011.149 · 2011 · External reference

Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice

10.1016/j.bbadis.2020.165996 · 2021 · External reference

Farnesoid X receptor is essential for normal glucose homeostasis

10.1172/jci25604 · 2006 · External reference

Targeting of a bile acid receptor, Takeda G protein receptor 5 [TGR5], by a novel first-in-class competitive antagonist, SBI-364, diminishes hepatic and renal cystogenesis in polycystic liver and kidney disease

10.1021/acsptsci.4c00701 · 2025 · External reference

TGF-β/Smad signaling in renal fibrosis

10.3389/fphys.2015.00082 · 2015 · External reference

A human tissue-based model of renal inflammation

10.1016/j.yexcr.2024.114309 · 2024 · External reference

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling

10.1038/s41401-023-01113-7 · 2023 · External reference

Bile acids: natural ligands for an orphan nuclear receptor

10.1126/science.284.5418.1365 · 1999 · External reference

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

10.1111/j.1365-2982.2010.01487.x · 2010 · External reference

ImageJ2: ImageJ for the next generation of scientific image data

10.1186/s12859-017-1934-z · 2017 · External reference

Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

10.1194/jlr.ra119000307 · 2020 · External reference

Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis

10.1016/j.trsl.2015.11.007 · 2016 · External reference

TGR5-mediated bile acid sensing controls glucose homeostasis

10.1016/j.cmet.2009.08.001 · 2009 · External reference

Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option

10.1038/s41598-020-77436-w · 2020 · External reference

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

10.1016/s1097-2765(00)80348-2 · 1999 · External reference

G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes

10.1681/asn.2014121271 · 2016 · External reference

Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model

10.2337/db10-0019 · 2010 · External reference

The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

10.1002/hep.24525 · 2011 · External reference

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

10.1038/nature04330 · 2006 · External reference

Chronic kidney disease

10.1016/s0140-6736(16)32064-5 · 2017 · External reference

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

10.1073/pnas.051014398 · 2001 · External reference

Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition

10.1152/ajprenal.00151.2012 · 2012 · External reference

Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI

10.1126/scitranslmed.aay7591 · 2020 · External reference

Oleanolic acid alleviate intestinal inflammation by inhibiting Takeda G-coupled protein receptor (TGR) 5 mediated cell apoptosis

10.1039/d3fo04882a · 2024 · External reference

Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice

10.1073/pnas.1323977111 · 2014 · External reference

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

10.1073/pnas.0506982103 · 2006 · External reference

Activation of FXR protects against renal fibrosis via suppressing Smad3 expression

2016 · External reference

Comparative profiling of serum, urine, and feces bile acids in humans, rats, and mice

10.1038/s42003-024-06321-3 · 2024 · External reference

TGR5 rescues renal ischemia-reperfusion injury by suppressing ferroptosis and cAMP/PKA/Nrf2 axis

10.1016/j.ejphar.2026.178597 · 2026 · External reference

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

10.1038/s41467-022-33824-6 · 2022 · External reference

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

10.1152/ajpgi.00490.2005 · 2006 · External reference