Research graph
References from Perfluorooctanoic acid exposure inhibits round spermatid elongation by impeding ubiquitin–proteasome–mediated chromatin remodeling in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Chromatoid bodies in the regulation of spermatogenesis: novel role of GRTH
10.3390/cells11040613 · 2022 · External reference
Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes
2018 · External reference
Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility
10.1007/s00018-025-05831-5 · 2025 · External reference
EPC1/TIP60-mediated histone acetylation facilitates spermiogenesis in mice
10.1128/mcb.00082-17 · 2017 · External reference
H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat
10.1242/bio.20147302 · 2014 · External reference
Per- and polyfluoroalkyl substances in the environment
10.1126/science.abg9065 · 2022 · External reference
A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid
2019 · External reference
Ubiquitination-deficient mutations in human piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis
10.1016/j.cell.2017.04.034 · 2017 · External reference
Perfluorooctanoic acid (PFOA) exposure induces splenic atrophy via overactivation of macrophages in male mice
10.1016/j.jhazmat.2020.124862 · 2021 · External reference
Function of RAD6B and RNF8 in spermatogenesis
10.1080/15384101.2017.1361066 · 2018 · External reference
Chronic arsenic exposure lowered sperm motility via impairing ultra-microstructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male mice
10.1016/j.scitotenv.2020.139233 · 2020 · External reference
The dynamics and regulation of chromatin remodeling during spermiogenesis
10.1016/j.gene.2019.05.027 · 2019 · External reference
Molecular insights into sperm head shaping and its role in human male fertility
10.1093/humupd/dmaf003 · 2025 · External reference
Substrate receptors of proteasomes
10.1111/brv.12419 · 2018 · External reference
Environmental and occupational pesticide exposure and human sperm parameters: a navigation guide review
10.1016/j.tox.2021.153017 · 2022 · External reference
Comparative proteomic analysis of round and elongated spermatids during spermiogenesis in mice
10.1002/bmc.4799 · 2020 · External reference
Chd5 orchestrates chromatin remodelling during sperm development
10.1038/ncomms4812 · 2014 · External reference
Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis
10.1074/jbc.ra119.010496 · 2019 · External reference
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis
10.1016/j.devcel.2010.01.010 · 2010 · External reference
DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
10.1242/dev.201497 · 2023 · External reference
Assessment of spermatogenesis through staging of seminiferous tubules
10.1007/978-1-62703-038-0_27 · 2013 · External reference
L3MBTL2 regulates chromatin remodeling during spermatogenesis
10.1038/s41418-019-0283-z · 2019 · External reference
Acute and chronic effects of gold nanoparticles on sperm parameters and chromatin structure in Mice
2016 · External reference
The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
10.1186/s12915-022-01368-2 · 2022 · External reference
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
10.1038/nature06236 · 2007 · External reference
The role of tubulin polymerization-promoting protein2 (TPPP2) in spermatogenesis: a narrative review
10.3390/ijms25137017 · 2024 · External reference
Profiles of emerging and legacy per-/polyfluoroalkyl substances in matched serum and semen samples: new implications for human semen quality
10.1289/ehp4431 · 2019 · External reference
Protective effects of resveratrol against perfluorooctanoic acid-induced testicular and epididymal toxicity in adult rats exposed during their prepubertal period
10.3390/toxics13020111 · 2025 · External reference
Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier
10.1016/j.scitotenv.2022.157313 · 2022 · External reference
Perspectives on mammalian chromatoid body research
10.1016/j.anireprosci.2015.05.018 · 2015 · External reference
Pollutants and sperm quality: a systematic review and meta-analysis
10.1007/s11356-020-11589-z · 2021 · External reference
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis
10.1016/j.cell.2013.04.032 · 2013 · External reference
Decoding the spermatogenesis program: new insights from transcriptomic analyses
10.1146/annurev-genet-080320-040045 · 2022 · External reference
Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used
10.1093/humrep/deac261 · 2023 · External reference
Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility
10.1016/j.ydbio.2007.09.053 · 2007 · External reference
Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice: Insights into epigenetic mechanisms and pathway-specific responses
10.1016/j.envint.2024.108556 · 2024 · External reference
Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq
10.1016/j.jhazmat.2025.137375 · 2025 · External reference
Seminal per- and polyfluoroalkyl substance exposure and sperm quality impairment: from toxic target to rescue
10.1016/j.envint.2025.109533 · 2025 · External reference
Biomonitoring PFAAs in blood and semen samples: Investigation of a potential link between PFAAs exposure and semen mobility in China
10.1016/j.envint.2018.01.010 · 2018 · External reference
Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence
2023 · External reference
PFOA exposure decreases acrosome reaction and increases DNA oxidative damage by impairing the sperm head shaping in mice
2026 · External reference
Essential role of histone replacement and modifications in male fertility
10.3389/fgene.2019.00962 · 2019 · External reference
PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis
2019 · External reference
piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis
10.1038/s41467-024-46664-3 · 2024 · External reference
Male reproductive toxicity involved in spermatogenesis induced by perfluorooctane sulfonate and perfluorooctanoic acid in Caenorhabditis elegans
10.1007/s11356-020-10530-8 · 2021 · External reference
Role of the ubiquitin-proteasome system in mammalian male germ cell differentiation and reproductive fitness
10.1002/mrd.70050 · 2025 · External reference
Proteomic analysis of mouse testis reveals perfluorooctanoic acid-induced reproductive dysfunction via direct disturbance of testicular steroidogenic machinery
10.1021/pr500228d · 2014 · External reference
Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
10.1038/s41467-019-11346-y · 2019 · External reference
MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation
10.1007/s00418-012-1043-z · 2013 · External reference
Stage-resolved phosphoproteomic landscape of mouse spermiogenesis reveals key kinase signaling in sperm morphogenesis
10.1002/advs.202508538 · 2025 · External reference
Mitotic bookmarking by SWI/SNF subunits
10.1038/s41586-023-06085-6 · 2023 · External reference
CHD5 is required for spermiogenesis and chromatin condensation
10.1016/j.mod.2013.10.005 · 2014 · External reference
