Research graph
References from Dimethomorph exposure alters human granulosa cells and mouse ovarian physiology. Local targets link to admitted publications; unresolved targets remain external evidence.
WikiPathways 2024: next generation pathway database
10.1093/nar/gkad960 · 2024 · External reference
IGF1R expression in ovarian granulosa cells is essential for steroidogenesis, follicle survival, and fertility in female mice
10.1210/en.2017-00146 · 2017 · External reference
Carbendazim detection in human follicular fluid: Impact on human granulosa cell function (KGNs and primary cells) and mouse ovarian physiology
10.1016/j.etap.2026.105089 · 2026 · External reference
Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries
10.1016/j.toxlet.2022.11.010 · 2023 · External reference
The multiple roles of estrogens and the enzyme aromatase
10.1016/s0079-6123(08)81012-6 · 2010 · External reference
Mouse estrous cycle identification tool and images
10.1371/journal.pone.0035538 · 2012 · External reference
Validation d’une méthode immuno-enzymatique pour le dosage de la progestérone dans le plasma des ovins et des bovins
2008 · External reference
Expression and Regulation of INTELECTIN1 in Human Granulosa-Lutein Cells: Role in IGF-1-Induced Steroidogenesis Through NAMPT
2014 · External reference
Understanding interleukin 11 as a disease gene and therapeutic target
10.1042/bcj20220160 · 2023 · External reference
A synthetic kisspeptin analog that triggers ovulation and advances puberty
10.1038/srep26908 · 2016 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Peer review of the pesticide risk assessment of the active substance dimethomorph
2023 · External reference
The nf-core framework for community-curated bioinformatics pipelines
10.1038/s41587-020-0439-x · 2020 · External reference
Combined Developmental Toxicity of the Pesticides Difenoconazole and Dimethomorph on Embryonic Zebrafish
10.3390/toxins13120854 · 2021 · External reference
Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
10.1093/humupd/dmm040 · 2008 · External reference
Effects of organochlorine pesticides on human and rat 17β-hydroxysteroid dehydrogenase 1 activity: Structure-activity relationship and in silico docking analysis
10.1016/j.jsbmb.2024.106510 · 2024 · External reference
Cortisol/glucocorticoid receptor: a critical mediator of the ovulatory process and luteinization in human periovulatory follicles
10.1093/humrep/dead017 · 2023 · External reference
Adjusting batch effects in microarray expression data using empirical Bayes methods
10.1093/biostatistics/kxj037 · 2007 · External reference
Effects of dimethomorph on the morphology and ultrastructure of Phytophthora
10.1016/s0953-7562(09)81244-6 · 1991 · External reference
Peroxisome Proliferator–Activated Receptor-γ Mediates Bisphenol A Inhibition of FSH-Stimulated IGF-1, Aromatase, and Estradiol in Human Granulosa Cells
10.1289/ehp.0901161 · 2010 · External reference
Comparative Transcriptome Analysis to Investigate the Immunotoxicity Mechanism Triggered by Dimethomorph on Human Jurkat T Cell Lines
10.3390/foods11233848 · 2022 · External reference
gprofiler2 -- an R package for gene list functional enrichment analysis and namespace conversion toolset g
2020 · External reference
The distributions of three fungicides in vegetables and their potential health risks in Zhejiang, China: A 3-year study (2015–2017)
10.1016/j.envpol.2020.115481 · 2020 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Role of Insulin-Like Growth Factor-I (IGF-I) and Kit Ligand (KL) in Ovarian Function
2015 · External reference
Combined anti-androgenic effects of mixtures of agricultural pesticides using in vitro and in silico methods
10.1016/j.ecoenv.2019.109652 · 2019 · External reference
Dimethomorph degradation in vineyards examined by isomeric and isotopic fractionation
10.1016/j.chemosphere.2022.137341 · 2023 · External reference
Role of ERK1/2 in the Differential Synthesis of Progesterone and Estradiol by Granulosa Cells
10.1006/bbrc.2001.6052 · 2001 · External reference
Methods for quantifying follicular numbers within the mouse ovary
10.1530/rep.1.00095 · 2004 · External reference
Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor
10.1210/endo.142.1.7862 · 2001 · External reference
Development of a Highly Sensitive ELISA for Measurement of FSH in Serum, Plasma, and Whole Blood in Mice
10.1210/endocr/bqab014 · 2021 · External reference
Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens
10.1289/ehp.1002895 · 2011 · External reference
Salmon provides fast and bias-aware quantification of transcript expression
10.1038/nmeth.4197 · 2017 · External reference
The aldo-keto reductases (AKRs): Overview
10.1016/j.cbi.2014.09.024 · 2015 · External reference
Unresolved reference
External reference
Effects of glyphosate on the ovarian function of pregnant mice, the secretion of hormones and the sex ratio of their fetuses
10.1016/j.envpol.2018.09.049 · 2018 · External reference
Induction and Inhibition of Aromatase (CYP19) Activity by Various Classes of Pesticides in H295R Human Adrenocortical Carcinoma Cells
10.1006/taap.2002.9420 · 2002 · External reference
The Role of Mitogen-Activated Protein Kinase in Insulin and Insulin-Like Growth Factor I (IGF-I) Signaling Cascades for Progesterone and IGF-Binding Protein-1 Production in Human Granulosa Cells
10.1210/jc.2002-021965 · 2003 · External reference
Cholesterol Biosynthesis and Homeostasis in Regulation of the Cell Cycle
2013 · External reference
Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice
10.1210/en.2013-1502 · 2013 · External reference
The role of the steroidogenic acute regulatory protein in steroidogenesis
10.1016/s0039-128x(96)00155-9 · 1997 · External reference
Anti-Müllerian hormone: a new marker for ovarian function
10.1530/rep.1.00529 · 2006 · External reference
Toxicological effects of dimethomorph on soil enzymatic activity and soil earthworm (Eisenia fetida)
10.1016/j.chemosphere.2016.11.090 · 2017 · External reference
Human cytochrome P450 3A-mediated two-step oxidation metabolism of dimethomorph: Implications in the mechanism-based enzyme inactivation
10.1016/j.scitotenv.2022.153585 · 2022 · External reference
Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells
10.1210/endocr/bqad089 · 2023 · External reference
Toxicological mechanisms and potencies of organophosphate esters in KGN human ovarian granulosa cells as revealed by high-throughput transcriptomics
10.1093/toxsci/kfad114 · 2024 · External reference
Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes
10.1073/pnas.1314829110 · 2013 · External reference
Dissipation and residue of dimethomorph in potato plants produced and dietary intake risk assessment
10.1080/03067319.2020.1737037 · 2022 · External reference
Protein Kinase B Is Obligatory for Follicle-Stimulating Hormone-Induced Granulosa Cell Differentiation
10.1210/en.2003-0293 · 2003 · External reference
Rapid degradation of dimethomorph in polluted water and soil by Bacillus cereus WL08 immobilized on bamboo charcoal–sodium alginate
10.1016/j.jhazmat.2020.122806 · 2020 · External reference
Single-cell dissection of dimethomorph-induced neurotoxicity in the gestational brain: metabolic disruption and blood–brain barrier dysfunction
10.1021/acs.est.5c11595 · 2026 · External reference
