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The functions and regulation of the PTEN tumour suppressor

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PTEN in DNA damage repair

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The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network

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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms

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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

10.1093/hmg/ddr337 · 2011 · External reference

Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era

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Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme

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Worse outcome in primary glioblastoma multiforme with concurrent epidermal growth factor receptor and p53 alteration

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PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel

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PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas

2001 · External reference

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival

2002 · External reference

Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN

2003 · External reference

PTEN signaling in brain: neuropathology and tumorigenesis

10.1038/onc.2008.239 · 2008 · External reference

The comet assay: a method to measure DNA damage in individual cells

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients

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Cluster analysis and display of genome-wide expression patterns

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Linking PTEN with genomic instability and DNA repair

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PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway

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Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

10.1074/jbc.m303621200 · 2003 · External reference

Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells

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Pathology: commonly moni- tored glioblastoma markers: EFGR, EGFRvIII, PTEN, and MGMT

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

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Mutant p53: one name, many proteins

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Interactions of mutant p53 with DNA: guilt by association

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