Research graph
References from Antiangiogenic Therapy Using Sunitinib Combined with Rapamycin Retards Tumor Growth But Promotes Metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Tumor angiogenesis: molecular pathways and therapeutic targets
10.1038/nm.2537 · 2011 · External reference
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
1999 · External reference
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
10.1016/j.ccr.2009.01.027 · 2009 · External reference
Hypoxia signalling in cancer and approaches to enforce tumour regression
10.1038/nature04871 · 2006 · External reference
Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early- stage invasive cervical cancer
2000 · External reference
Direct regulation of TWIST by HIF-1α promotes metastasis
10.1038/ncb1691 · 2008 · External reference
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
10.1016/j.cell.2004.06.006 · 2004 · External reference
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/phar macodynamic relationship
2003 · External reference
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
10.1200/jco.2007.14.5375 · 2008 · External reference
Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts
10.1016/j.canlet.2008.05.007 · 2008 · External reference
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
10.1073/pnas.1018866109 · 2012 · External reference
PI(3)K and mTOR signalling controls tumour cell growth
10.1038/nature04869 · 2006 · External reference
The translational landscape of mTOR signalling steers cancer initiation and metastasis
10.1038/nature10912 · 2012 · External reference
Akt takes center stage in angiogenesis signaling
10.1161/01.res.86.1.4 · 2000 · External reference
Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis
10.1172/jci24726 · 2005 · External reference
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
10.1016/j.ccr.2006.07.003 · 2006 · External reference
Differential ffects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells
2003 · External reference
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
10.1038/nm0202-128 · 2002 · External reference
Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
10.1038/sj.bjc.6602162 · 2004 · External reference
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
10.1038/nm1337 · 2006 · External reference
Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors
10.1158/0008-5472.can-10-2029 · 2010 · External reference
Molecular mechanisms and clinical applications of angiogenesis
10.1038/nature10144 · 2011 · External reference
Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate
10.1152/ajprenal.00710.2010 · 2011 · External reference
Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma
10.1007/s10585-012-9526-9 · 2013 · External reference
Everolimus for advanced pancreatic neuroendocrine tumors
10.1056/nejmoa1009290 · 2011 · External reference
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
10.1016/j.ccr.2004.08.031 · 2004 · External reference
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
10.1182/blood-2008-02-137430 · 2008 · External reference
mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer
10.1158/0008-5472.can-11-2089 · 2013 · External reference
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
10.1182/blood-2004-03-1109 · 2004 · External reference
Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
10.1158/0008-5472.can-11-2905 · 2012 · External reference
