Research graph
References from Simvastatin Enhances the Effects of Radiotherapy and Cetuximab on a Cell Line (FaDu) Derived from a Squamous Cell Carcinoma of Head and Neck. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
10.1056/nejmoa053422 · 2006 · External reference
Cetuximab approved by FDA for treatment of head and neck squamous cell cancer
2006 · External reference
Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells
10.1158/1078-0432.ccr-08-2068 · 2009 · External reference
Direct visualization of Ras proteins in spatially distinct cell surface microdomains
10.1083/jcb.200209091 · 2003 · External reference
Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?
10.1182/blood.v96.5.1655 · 2000 · External reference
Lipid rafts and signal transduction
10.1038/35036052 · 2000 · External reference
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
10.1016/j.cell.2011.12.017 · 2011 · External reference
Epidermal growth factor competes with EGF receptor inhibitors to induce cell death in EGFR-overexpressing tumor cells
10.1016/j.canlet.2009.03.034 · 2009 · External reference
Development and refinement of a technique using a medical radiation therapy facility to irradiate immunodeficient mice bearing xenografted human tumours
10.1258/la.2012.011147 · 2012 · External reference
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
10.1124/jpet.104.075028 · 2005 · External reference
Effect of simvastatin on glioma cell proliferation, migration, and apoptosis
10.1227/01.neu.0000360130.52812.1d · 2009 · External reference
Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations
10.1093/jnci/djr070 · 2011 · External reference
Cetuximab may inhibit tumor growth and angiogenesis induced by ionizing radiation: a preclinical rationale for maintenance treatment after radiotherapy
10.1634/theoncologist.2008-0290 · 2010 · External reference
Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression
10.1097/jto.0b013e3182049d8b · 2011 · External reference
Development and characterization of an isogenic cell line with a radioresistant phenotype
10.1007/s12094-012-0898-8 · 2013 · External reference
p70 S6 Kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation
10.1074/jbc.274.38.26776 · 1999 · External reference
The potential of statins as part of anti-cancer treatment
10.1016/j.ejca.2004.12.009 · 2005 · External reference
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
1999 · External reference
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
10.1038/sj.onc.1201275 · 1997 · External reference
The statins as anticancer agents
2003 · External reference
The role of statins in cancer therapy
10.1634/theoncologist.11-3-306 · 2006 · External reference
Statins, stem cells, and cancer
10.1002/jcb.22092 · 2009 · External reference
Use of intravascular ultrasound to compare effects of different strategies of lipid-lowering therapy on plaque volume and composition in patients with coronary artery disease
10.1161/hc2901.093188 · 2001 · External reference
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy
10.1073/pnas.122228799 · 2002 · External reference
Simvastatin, an inhibitor of cholesterol biosynthesis, shows a synergistic effect with N,N′-bis(2-chloroethyl)-N-nitrosourea and β-interferon on human glioma cells
1992 · External reference
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications
2001 · External reference
Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling
10.1038/sj.onc.1209117 · 2006 · External reference
Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines
10.1016/s0014-5793(02)03575-5 · 2002 · External reference
Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells
10.1038/sj.bjp.0705928 · 2004 · External reference
Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation
10.1002/ijc.2910530222 · 1993 · External reference
The risk of cancer in users of statins
10.1200/jco.2004.02.027 · 2004 · External reference
The association between 3-hydroxy-3-methylglutaryl coenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: a case-control study
10.1002/cncr.20271 · 2004 · External reference
Statin use and risk of prostate cancer recurrence in men treated with radiation therapy
10.1200/jco.2009.27.3003 · 2010 · External reference
Statin use and reduced cancer-related mortality
10.1056/nejmoa1201735 · 2012 · External reference
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial
10.1054/bjoc.2000.1716 · 2001 · External reference
The epidermal growth factor receptor mediates radioresistance
10.1016/s0360-3016(03)00511-x · 2003 · External reference
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
1996 · External reference
A phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix
10.1016/j.ejca.2004.12.013 · 2005 · External reference
Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma
10.1023/a:1006481423298 · 2001 · External reference
Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters
10.1016/s0090-9556(24)15082-9 · 2000 · External reference
