Research graph
References from Paired bulk transcriptomic analysis of recurrent glioblastoma with primary single-cell reference mapping. Local targets link to admitted publications; unresolved targets remain external evidence.
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2016-2020
2023 · External reference
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Glioblastoma in adults: a society for Neuro-Oncology (SNO) and European society of Neuro-Oncology (EANO) consensus review on current management and future directions
10.1093/neuonc/noaa106 · 2020 · External reference
The 2021 WHO classification of tumors of the central nervous system: a summary
10.1093/neuonc/noab106 · 2021 · External reference
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma
10.1016/j.ccr.2009.12.020 · 2010 · External reference
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
10.1016/j.ccell.2017.06.003 · 2017 · External reference
Longitudinal molecular trajectories of diffuse glioma in adults
10.1038/s41586-019-1775-1 · 2019 · External reference
Glioma progression is shaped by genetic evolution and microenvironment interactions
10.1016/j.cell.2022.04.038 · 2022 · External reference
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
10.1016/j.ccell.2023.02.019 · 2023 · External reference
Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis
10.1016/j.ccell.2019.02.007 · 2019 · External reference
An integrative model of cellular states, plasticity, and genetics for glioblastoma
10.1016/j.cell.2019.06.024 · 2019 · External reference
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
10.1126/science.1254257 · 2014 · External reference
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
10.1038/nature20123 · 2016 · External reference
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
10.1038/s41467-020-17186-5 · 2020 · External reference
The phenotypes of proliferating glioblastoma cells reside on a single axis of variation
10.1158/2159-8290.cd-19-0329 · 2019 · External reference
Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma
10.1016/j.stem.2019.11.015 · 2020 · External reference
Glioblastoma hijacks neuronal mechanisms for brain invasion
10.1016/j.cell.2022.06.054 · 2022 · External reference
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
10.1038/s43018-020-00154-9 · 2021 · External reference
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
10.1016/j.ccell.2021.05.002 · 2021 · External reference
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
10.1016/j.cell.2021.03.023 · 2021 · External reference
Challenges in glioblastoma research: focus on the tumor microenvironment
10.1016/j.trecan.2022.09.005 · 2023 · External reference
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
10.1186/s13059-017-1362-4 · 2017 · External reference
Single-cell RNA-seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma
10.1016/j.celrep.2017.10.030 · 2017 · External reference
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
10.1038/s41593-020-00789-y · 2021 · External reference
Single-cell mapping of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes
10.1016/j.cell.2020.04.055 · 2020 · External reference
Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells
10.1016/j.cell.2020.05.007 · 2020 · External reference
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
10.1186/s13073-021-00906-x · 2021 · External reference
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
10.1038/s41467-022-28372-y · 2022 · External reference
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
10.1038/s43018-022-00475-x · 2022 · External reference
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
10.1038/s41588-021-00926-8 · 2021 · External reference
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
10.1038/s43018-020-00159-4 · 2021 · External reference
Intratumoral heterogeneity and longitudinal changes in gene expression predict differential drug sensitivity in newly diagnosed and recurrent glioblastoma
10.3390/cancers12020520 · 2020 · External reference
The somatic genomic landscape of glioblastoma
10.1016/j.cell.2013.09.034 · 2013 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma
10.1111/cas.15773 · 2023 · External reference
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth
10.1016/j.stem.2014.01.005 · 2014 · External reference
Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo
10.1002/ijc.29454 · 2015 · External reference
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: significance of CD44 and osteopontin as therapeutic targets in glioblastoma
10.1016/j.tranon.2021.101137 · 2021 · External reference
Disruption of intracerebral progression of C6 rat glioblastoma by in vivo treatment with anti-CD44 monoclonal antibody
10.3171/jns.2000.92.1.0140 · 2000 · External reference
Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo
10.1016/j.radonc.2007.05.003 · 2007 · External reference
Effect of osteopontin silencing by lentivirus-mediated delivery of siRNA on glioma cell invasion and apoptosis
2009 · External reference
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells
10.1093/neuonc/noq006 · 2010 · External reference
Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review
2021 · External reference
Chemoresistance to temozolomide in human glioma cell line U251 is associated with increased activity of O6-methylguanine-DNA methyltransferase and can be overcome by metronomic temozolomide regimen
10.1007/s12013-011-9280-7 · 2012 · External reference
Forkhead box protein O3a promotes glioma cell resistance to temozolomide by regulating matrix metallopeptidase and β-catenin
10.3892/ol.2021.12580 · 2021 · External reference
Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells
10.1038/s41598-023-48777-z · 2023 · External reference
Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo
10.1002/ijc.29454 · ExternalCitation · doi-reference
Chemoresistance to temozolomide in human glioma cell line U251 is associated with increased activity of O6-methylguanine-DNA methyltransferase and can be overcome by metronomic temozolomide regimen
10.1007/s12013-011-9280-7 · ExternalCitation · doi-reference
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
10.1016/j.ccell.2017.06.003 · ExternalCitation · doi-reference
Evolutionary trajectories of IDHWT glioblastomas reveal a common path of early tumorigenesis instigated years ahead of initial diagnosis
10.1016/j.ccell.2019.02.007 · ExternalCitation · doi-reference
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
10.1016/j.ccell.2021.05.002 · ExternalCitation · doi-reference
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
10.1016/j.ccell.2023.02.019 · ExternalCitation · doi-reference
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma
10.1016/j.ccr.2009.12.020 · ExternalCitation · doi-reference
The somatic genomic landscape of glioblastoma
10.1016/j.cell.2013.09.034 · ExternalCitation · doi-reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · ExternalCitation · doi-reference
An integrative model of cellular states, plasticity, and genetics for glioblastoma
10.1016/j.cell.2019.06.024 · ExternalCitation · doi-reference
Single-cell mapping of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes
10.1016/j.cell.2020.04.055 · ExternalCitation · doi-reference
Interrogation of the microenvironmental landscape in brain tumors reveals disease-specific alterations of immune cells
10.1016/j.cell.2020.05.007 · ExternalCitation · doi-reference
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
10.1016/j.cell.2021.03.023 · ExternalCitation · doi-reference
Glioma progression is shaped by genetic evolution and microenvironment interactions
10.1016/j.cell.2022.04.038 · ExternalCitation · doi-reference
Glioblastoma hijacks neuronal mechanisms for brain invasion
10.1016/j.cell.2022.06.054 · ExternalCitation · doi-reference
Single-cell RNA-seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma
10.1016/j.celrep.2017.10.030 · ExternalCitation · doi-reference
Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo
10.1016/j.radonc.2007.05.003 · ExternalCitation · doi-reference
Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth
10.1016/j.stem.2014.01.005 · ExternalCitation · doi-reference
Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma
10.1016/j.stem.2019.11.015 · ExternalCitation · doi-reference
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: significance of CD44 and osteopontin as therapeutic targets in glioblastoma
10.1016/j.tranon.2021.101137 · ExternalCitation · doi-reference
Challenges in glioblastoma research: focus on the tumor microenvironment
10.1016/j.trecan.2022.09.005 · ExternalCitation · doi-reference
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
10.1038/nature20123 · ExternalCitation · doi-reference
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
10.1038/s41467-020-17186-5 · ExternalCitation · doi-reference
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
10.1038/s41467-022-28372-y · ExternalCitation · doi-reference
Longitudinal molecular trajectories of diffuse glioma in adults
10.1038/s41586-019-1775-1 · ExternalCitation · doi-reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · ExternalCitation · doi-reference
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
10.1038/s41588-021-00926-8 · ExternalCitation · doi-reference
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
10.1038/s41593-020-00789-y · ExternalCitation · doi-reference
Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells
10.1038/s41598-023-48777-z · ExternalCitation · doi-reference
Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
10.1038/s43018-020-00154-9 · ExternalCitation · doi-reference
Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
10.1038/s43018-020-00159-4 · ExternalCitation · doi-reference
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
10.1038/s43018-022-00475-x · ExternalCitation · doi-reference
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · ExternalCitation · doi-reference
Glioblastoma in adults: a society for Neuro-Oncology (SNO) and European society of Neuro-Oncology (EANO) consensus review on current management and future directions
10.1093/neuonc/noaa106 · ExternalCitation · doi-reference
The 2021 WHO classification of tumors of the central nervous system: a summary
10.1093/neuonc/noab106 · ExternalCitation · doi-reference
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells
10.1093/neuonc/noq006 · ExternalCitation · doi-reference
Single-cell RNA sequencing reveals tumor heterogeneity, microenvironment, and drug-resistance mechanisms of recurrent glioblastoma
10.1111/cas.15773 · ExternalCitation · doi-reference
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
10.1126/science.1254257 · ExternalCitation · doi-reference
The phenotypes of proliferating glioblastoma cells reside on a single axis of variation
10.1158/2159-8290.cd-19-0329 · ExternalCitation · doi-reference
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
10.1186/s13059-017-1362-4 · ExternalCitation · doi-reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · ExternalCitation · doi-reference
Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker
10.1186/s13073-021-00906-x · ExternalCitation · doi-reference
Disruption of intracerebral progression of C6 rat glioblastoma by in vivo treatment with anti-CD44 monoclonal antibody
10.3171/jns.2000.92.1.0140 · ExternalCitation · doi-reference
Intratumoral heterogeneity and longitudinal changes in gene expression predict differential drug sensitivity in newly diagnosed and recurrent glioblastoma
10.3390/cancers12020520 · ExternalCitation · doi-reference
Forkhead box protein O3a promotes glioma cell resistance to temozolomide by regulating matrix metallopeptidase and β-catenin
10.3892/ol.2021.12580 · ExternalCitation · doi-reference
