Research graph
References from Integrative single-cell and spatial transcriptomic analyses identify LMX1B as a tumor suppressor orchestrating the GDF15–ATP4B axis in renal cell carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Treatment of spinal metastases in renal cell carcinoma: A critical review
10.1016/j.critrevonc.2018.02.017 · 2018 · External reference
Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities
10.1186/s40164-026-00775-3 · 2026 · External reference
Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
10.1038/s12276-023-01020-1 · 2023 · External reference
Tumor microenvironment heterogeneity and immunotherapy resistance: multidimensional modulation strategies for precision breakthroughs
2026 · External reference
Efficacy and safety of immune checkpoint inhibitors combined with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma: a risk-stratified systematic review and meta-analysis
10.3389/fimmu.2026.1805039 · 2026 · External reference
Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics
10.1016/j.trecan.2025.11.001 · 2026 · External reference
Advancements in single-cell RNA sequencing and spatial transcriptomics: transforming biomedical research
10.3389/abp.2025.13922 · 2025 · External reference
Integrating multi-omics data: Methods and applications in human complex diseases
2025 · External reference
Targeting the Tumor Microenvironment in Renal Cell Cancer Biology and Therapy
10.3389/fonc.2019.00490 · 2019 · External reference
10.3389/fimmu.2025.1643533
10.3389/fimmu.2025.1643533 · External reference
The Human Transcription Factors
10.1016/j.cell.2018.01.029 · 2018 · External reference
Spectrum of LMX1B mutations: from nail-patella syndrome to isolated nephropathy
10.1007/s00467-016-3462-x · 2017 · External reference
Diversity and complexity in DNA recognition by transcription factors
10.1126/science.1162327 · 2009 · External reference
Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b
10.1016/j.febslet.2015.10.020 · 2015 · External reference
LMX1B activated circular RNA GFRA1 Modulates the tumorigenic properties and immune escape of prostate cancer
10.1155/2022/7375879 · 2022 · External reference
LMX1B involved in the radioresistance, proliferation and migration of esophageal cancer cells
10.1016/j.biopha.2019.109358 · 2019 · External reference
Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression
10.1002/kjm2.12411 · 2021 · External reference
Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmo diet and cancer-cardiovascular cohort
10.1007/s00125-018-4751-7 · 2019 · External reference
The multiple facets of the TGF-beta family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1
10.1016/j.cytogfr.2013.05.003 · 2013 · External reference
Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation
10.1016/j.jep.2021.113964 · 2021 · External reference
NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15
10.1038/s41420-021-00462-8 · 2021 · External reference
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts
10.62347/kyiy8286 · 2025 · External reference
ESRRG, ATP4A, and ATP4B as diagnostic biomarkers for gastric cancer: a bioinformatic analysis based on machine learning
2022 · External reference
Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation
10.1007/s10120-020-01128-7 · 2021 · External reference
10.1016/j.ymeth.2022.09.008
10.1016/j.ymeth.2022.09.008 · External reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · 2019 · External reference
UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses
10.1016/j.neo.2017.05.002 · 2017 · External reference
UALCAN: an update to the integrated cancer data analysis platform
10.1016/j.neo.2022.01.001 · 2022 · External reference
JASPAR 2020: update of the open-access database of transcription factor binding profiles
2020 · External reference
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
10.1093/nar/gkab1113 · 2022 · External reference
Explainable multiview framework for dissecting spatial relationships from highly multiplexed data
10.1186/s13059-022-02663-5 · 2022 · External reference
10.3389/fimmu.2025.1649468
10.3389/fimmu.2025.1649468 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
2023 · External reference
Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells
2022 · External reference
GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells
10.18632/oncotarget.7457 · 2016 · External reference
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
10.3389/fonc.2022.985363 · 2022 · External reference
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
10.1002/cbin.11137 · 2019 · External reference
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma
10.1038/s41388-022-02512-6 · 2022 · External reference
Schisandrin B antagonizes cardiotoxicity induced by pirarubicin by inhibiting mitochondrial permeability transition pore (mPTP) opening and decreasing cardiomyocyte apoptosis
2021 · External reference
10.1097/cej.0000000000001000
10.1097/cej.0000000000001000 · External reference
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
10.1002/cbin.11137 · ExternalCitation · doi-reference
Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression
10.1002/kjm2.12411 · ExternalCitation · doi-reference
Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmo diet and cancer-cardiovascular cohort
10.1007/s00125-018-4751-7 · ExternalCitation · doi-reference
Spectrum of LMX1B mutations: from nail-patella syndrome to isolated nephropathy
10.1007/s00467-016-3462-x · ExternalCitation · doi-reference
Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation
10.1007/s10120-020-01128-7 · ExternalCitation · doi-reference
LMX1B involved in the radioresistance, proliferation and migration of esophageal cancer cells
10.1016/j.biopha.2019.109358 · ExternalCitation · doi-reference
The Human Transcription Factors
10.1016/j.cell.2018.01.029 · ExternalCitation · doi-reference
Treatment of spinal metastases in renal cell carcinoma: A critical review
10.1016/j.critrevonc.2018.02.017 · ExternalCitation · doi-reference
The multiple facets of the TGF-beta family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1
10.1016/j.cytogfr.2013.05.003 · ExternalCitation · doi-reference
Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b
10.1016/j.febslet.2015.10.020 · ExternalCitation · doi-reference
Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation
10.1016/j.jep.2021.113964 · ExternalCitation · doi-reference
UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses
10.1016/j.neo.2017.05.002 · ExternalCitation · doi-reference
UALCAN: an update to the integrated cancer data analysis platform
10.1016/j.neo.2022.01.001 · ExternalCitation · doi-reference
Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics
10.1016/j.trecan.2025.11.001 · ExternalCitation · doi-reference
10.1016/j.ymeth.2022.09.008
10.1016/j.ymeth.2022.09.008 · ExternalCitation · doi-reference
Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
10.1038/s12276-023-01020-1 · ExternalCitation · doi-reference
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma
10.1038/s41388-022-02512-6 · ExternalCitation · doi-reference
NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15
10.1038/s41420-021-00462-8 · ExternalCitation · doi-reference
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
10.1038/s41467-019-09234-6 · ExternalCitation · doi-reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · ExternalCitation · doi-reference
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
10.1093/nar/gkab1113 · ExternalCitation · doi-reference
10.1097/cej.0000000000001000
10.1097/cej.0000000000001000 · ExternalCitation · doi-reference
Diversity and complexity in DNA recognition by transcription factors
10.1126/science.1162327 · ExternalCitation · doi-reference
LMX1B activated circular RNA GFRA1 Modulates the tumorigenic properties and immune escape of prostate cancer
10.1155/2022/7375879 · ExternalCitation · doi-reference
Explainable multiview framework for dissecting spatial relationships from highly multiplexed data
10.1186/s13059-022-02663-5 · ExternalCitation · doi-reference
Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities
10.1186/s40164-026-00775-3 · ExternalCitation · doi-reference
GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells
10.18632/oncotarget.7457 · ExternalCitation · doi-reference
Advancements in single-cell RNA sequencing and spatial transcriptomics: transforming biomedical research
10.3389/abp.2025.13922 · ExternalCitation · doi-reference
10.3389/fimmu.2025.1643533
10.3389/fimmu.2025.1643533 · ExternalCitation · doi-reference
10.3389/fimmu.2025.1649468
10.3389/fimmu.2025.1649468 · ExternalCitation · doi-reference
Efficacy and safety of immune checkpoint inhibitors combined with tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma: a risk-stratified systematic review and meta-analysis
10.3389/fimmu.2026.1805039 · ExternalCitation · doi-reference
Targeting the Tumor Microenvironment in Renal Cell Cancer Biology and Therapy
10.3389/fonc.2019.00490 · ExternalCitation · doi-reference
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
10.3389/fonc.2022.985363 · ExternalCitation · doi-reference
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts
10.62347/kyiy8286 · ExternalCitation · doi-reference
