Research graph
References from A randomised, double-blind, placebo-controlled phase I clinical trial to evaluate the safety, tolerability and immunogenicity of three doses of an adjuvanted group B Streptococcus vaccine in older adults aged 55 to 75. Local targets link to admitted publications; unresolved targets remain external evidence.
Group B streptococcal colonization, molecular characteristics, and epidemiology
10.3389/fmicb.2018.00437 · 2018 · External reference
The risk factors for group B Streptococcus colonization during pregnancy and influences of intrapartum antibiotic prophylaxis on maternal and neonatal outcomes
10.1186/s12884-023-05478-9 · 2023 · External reference
Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study
10.1007/s15010-022-01965-x · 2023 · External reference
Burden of invasive group B Streptococcus disease in non-pregnant adults: a systematic review and meta-analysis
10.1371/journal.pone.0258030 · 2021 · External reference
The changing epidemiology of group B Streptococcus bloodstream infection: a multi-national population-based assessment
10.3109/23744235.2015.1131330 · 2016 · External reference
Group B streptococcal infections in elderly adults
10.1086/432804 · 2005 · External reference
Group B streptococcal disease in nonpregnant adults
10.1086/322696 · 2001 · External reference
Dominance of serotype Ia among group B streptococci causing invasive infections in nonpregnant adults in Portugal
10.1128/jcm.05488-11 · 2012 · External reference
Obesity, diabetes, and the risk of invasive group B streptococcal disease in nonpregnant adults in the United States
10.1093/ofid/ofy030 · 2018 · External reference
Burden of adults hospitalized with group B streptococcal infection
10.1093/infdis/jiaa110 · 2021 · External reference
Group B Streptococcus infections of soft tissue and bone in California adults, 1995–2012
10.1017/s0950268815000606 · 2015 · External reference
Fluoroquinolone-resistant Streptococcus agalactiae invasive isolates recovered in Argentina
10.1089/mdr.2018.0246 · 2019 · External reference
Molecular characteristics and antibiotic resistance mechanisms of clindamycin-resistant Streptococcus agalactiae isolates in China
2023 · External reference
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015
10.2807/1560-7917.es.2018.23.21.1700473 · 2018 · External reference
Molecular characteristics of group B streptococci isolated from adults with invasive infections in Japan
10.1128/jcm.01183-16 · 2016 · External reference
Multistate, population-based distributions of candidate vaccine targets, clonal complexes, and resistance features of invasive group B streptococci within the United States, 2015–2017
10.1093/cid/ciaa151 · 2021 · External reference
Systematic review of group B streptococcal capsular types, sequence types and surface proteins as potential vaccine candidates
10.1016/j.vaccine.2020.08.052 · 2020 · External reference
Survey of immunological features of the alpha-like proteins of Streptococcus agalactiae
10.1128/cvi.00643-14 · 2015 · External reference
Safety and immunogenicity of the group B streptococcus vaccine AlpN in a placebo-controlled double-blind phase 1 trial
10.1016/j.isci.2023.106261 · 2023 · External reference
Safety and immunogenicity of a single booster dose of the group B streptococcus AlpN candidate vaccine (GBS-AlpN) in previously vaccinated healthy women compared with a single dose in previously unvaccinated women
10.1016/j.vaccine.2025.127820 · 2025 · External reference
Immunogenicity and safety of a group B Streptococcus vaccine (GBS-AlpN) in pregnant women and their infants: a phase 2, multicentre, observer-blind, randomised, placebo-controlled study
10.1016/s1473-3099(25)00659-0 · 2026 · External reference
Understanding immunosenescence and its impact on vaccination of older adults
10.1016/j.vaccine.2020.11.002 · 2020 · External reference
Obesity accelerates age defects in B cells, and weight loss improves B cell function
10.1186/s12979-023-00361-9 · 2023 · External reference
Invasive group B Streptococcus among non-pregnant adults in Brussels-capital region, 2005–2019
10.1007/s10096-020-04041-0 · 2021 · External reference
Immunosenescence: molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · 2023 · External reference
Immunosenescence: implications for response to infection and vaccination in older people
10.1016/j.maturitas.2015.05.004 · 2015 · External reference
Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005
10.1001/jama.299.17.2056 · 2008 · External reference
Incidence of invasive group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013-2017: a retrospective study at Thailand’s largest national tertiary referral center
10.1080/07853890.2021.1930138 · 2021 · External reference
Group B streptococcus-associated invasive infections in the adult, non-pregnant population; incidence, risk factors, and clinical presentations beyond borders
10.7861/clinmed.23-6-s46 · 2023 · External reference
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
10.3389/fragi.2024.1490302 · 2024 · External reference
Recombinant hepatitis B vaccine (Engerix-B): a review of its immunogenicity and protective efficacy against hepatitis B
10.2165/00003495-200363100-00006 · 2003 · External reference
The unmet need in the elderly: designing new influenza vaccines for older adults
10.1016/j.vaccine.2005.04.019 · 2005 · External reference
Obesity is associated with impaired immune response to influenza vaccination in humans
10.1038/ijo.2011.208 · 2012 · External reference
Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: the CoVaDiab study I
10.1002/dmrr.3601 · 2023 · External reference
The impact of obesity and metabolic syndrome on vaccination success
10.1159/000504440 · 2020 · External reference
Diabetes mellitus as a vaccine-effect modifier: a review
10.1080/14760584.2020.1760098 · 2020 · External reference
Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection
10.1056/nejm197604012941404 · 1976 · External reference
Unresolved reference
2026 · External reference
Correlates of protection of serotype-specific capsular antibody and invasive group B Streptococcus disease in south African infants
10.1016/j.vaccine.2015.10.019 · 2015 · External reference
Group B Streptococcus: developing a correlate of protection for a vaccine against neonatal infections
10.1097/qco.0000000000000266 · 2016 · External reference
Considerations for a phase-III trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of early- and late-onset invasive disease in young-infants
10.1016/j.vaccine.2013.02.029 · 2013 · External reference
Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005
10.1001/jama.299.17.2056 · ExternalCitation · doi-reference
Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow-up study: the CoVaDiab study I
10.1002/dmrr.3601 · ExternalCitation · doi-reference
Invasive group B Streptococcus among non-pregnant adults in Brussels-capital region, 2005–2019
10.1007/s10096-020-04041-0 · ExternalCitation · doi-reference
Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study
10.1007/s15010-022-01965-x · ExternalCitation · doi-reference
Safety and immunogenicity of the group B streptococcus vaccine AlpN in a placebo-controlled double-blind phase 1 trial
10.1016/j.isci.2023.106261 · ExternalCitation · doi-reference
Immunosenescence: implications for response to infection and vaccination in older people
10.1016/j.maturitas.2015.05.004 · ExternalCitation · doi-reference
The unmet need in the elderly: designing new influenza vaccines for older adults
10.1016/j.vaccine.2005.04.019 · ExternalCitation · doi-reference
Considerations for a phase-III trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of early- and late-onset invasive disease in young-infants
10.1016/j.vaccine.2013.02.029 · ExternalCitation · doi-reference
Correlates of protection of serotype-specific capsular antibody and invasive group B Streptococcus disease in south African infants
10.1016/j.vaccine.2015.10.019 · ExternalCitation · doi-reference
Systematic review of group B streptococcal capsular types, sequence types and surface proteins as potential vaccine candidates
10.1016/j.vaccine.2020.08.052 · ExternalCitation · doi-reference
Understanding immunosenescence and its impact on vaccination of older adults
10.1016/j.vaccine.2020.11.002 · ExternalCitation · doi-reference
Safety and immunogenicity of a single booster dose of the group B streptococcus AlpN candidate vaccine (GBS-AlpN) in previously vaccinated healthy women compared with a single dose in previously unvaccinated women
10.1016/j.vaccine.2025.127820 · ExternalCitation · doi-reference
Immunogenicity and safety of a group B Streptococcus vaccine (GBS-AlpN) in pregnant women and their infants: a phase 2, multicentre, observer-blind, randomised, placebo-controlled study
10.1016/s1473-3099(25)00659-0 · ExternalCitation · doi-reference
Group B Streptococcus infections of soft tissue and bone in California adults, 1995–2012
10.1017/s0950268815000606 · ExternalCitation · doi-reference
Obesity is associated with impaired immune response to influenza vaccination in humans
10.1038/ijo.2011.208 · ExternalCitation · doi-reference
Immunosenescence: molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · ExternalCitation · doi-reference
Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection
10.1056/nejm197604012941404 · ExternalCitation · doi-reference
Incidence of invasive group B Streptococcus (iGBS) infections and the factors associated with iGBS mortality in adults during 2013-2017: a retrospective study at Thailand’s largest national tertiary referral center
10.1080/07853890.2021.1930138 · ExternalCitation · doi-reference
Diabetes mellitus as a vaccine-effect modifier: a review
10.1080/14760584.2020.1760098 · ExternalCitation · doi-reference
Group B streptococcal disease in nonpregnant adults
10.1086/322696 · ExternalCitation · doi-reference
Group B streptococcal infections in elderly adults
10.1086/432804 · ExternalCitation · doi-reference
Fluoroquinolone-resistant Streptococcus agalactiae invasive isolates recovered in Argentina
10.1089/mdr.2018.0246 · ExternalCitation · doi-reference
Multistate, population-based distributions of candidate vaccine targets, clonal complexes, and resistance features of invasive group B streptococci within the United States, 2015–2017
10.1093/cid/ciaa151 · ExternalCitation · doi-reference
Burden of adults hospitalized with group B streptococcal infection
10.1093/infdis/jiaa110 · ExternalCitation · doi-reference
Obesity, diabetes, and the risk of invasive group B streptococcal disease in nonpregnant adults in the United States
10.1093/ofid/ofy030 · ExternalCitation · doi-reference
Group B Streptococcus: developing a correlate of protection for a vaccine against neonatal infections
10.1097/qco.0000000000000266 · ExternalCitation · doi-reference
Survey of immunological features of the alpha-like proteins of Streptococcus agalactiae
10.1128/cvi.00643-14 · ExternalCitation · doi-reference
Molecular characteristics of group B streptococci isolated from adults with invasive infections in Japan
10.1128/jcm.01183-16 · ExternalCitation · doi-reference
Dominance of serotype Ia among group B streptococci causing invasive infections in nonpregnant adults in Portugal
10.1128/jcm.05488-11 · ExternalCitation · doi-reference
The impact of obesity and metabolic syndrome on vaccination success
10.1159/000504440 · ExternalCitation · doi-reference
The risk factors for group B Streptococcus colonization during pregnancy and influences of intrapartum antibiotic prophylaxis on maternal and neonatal outcomes
10.1186/s12884-023-05478-9 · ExternalCitation · doi-reference
Obesity accelerates age defects in B cells, and weight loss improves B cell function
10.1186/s12979-023-00361-9 · ExternalCitation · doi-reference
Burden of invasive group B Streptococcus disease in non-pregnant adults: a systematic review and meta-analysis
10.1371/journal.pone.0258030 · ExternalCitation · doi-reference
Recombinant hepatitis B vaccine (Engerix-B): a review of its immunogenicity and protective efficacy against hepatitis B
10.2165/00003495-200363100-00006 · ExternalCitation · doi-reference
Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015
10.2807/1560-7917.es.2018.23.21.1700473 · ExternalCitation · doi-reference
The changing epidemiology of group B Streptococcus bloodstream infection: a multi-national population-based assessment
10.3109/23744235.2015.1131330 · ExternalCitation · doi-reference
Group B streptococcal colonization, molecular characteristics, and epidemiology
10.3389/fmicb.2018.00437 · ExternalCitation · doi-reference
The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
10.3389/fragi.2024.1490302 · ExternalCitation · doi-reference
Group B streptococcus-associated invasive infections in the adult, non-pregnant population; incidence, risk factors, and clinical presentations beyond borders
10.7861/clinmed.23-6-s46 · ExternalCitation · doi-reference
