Research graph
References from Innovation, development, and licensure of improved influenza vaccines: the way forward. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2019 · External reference
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2009 · External reference
Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability
2012 · External reference
Pandemic (H1N1) 2009: assessing the response
10.1503/cmaj.100900 · 2010 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2012 · External reference
2009 pandemic influenza a virus subtype H1N1 vaccination in Africa—successes and challenges
10.1093/infdis/jis535 · 2012 · External reference
Unresolved reference
External reference
The global H5N1 influenza panzootic in mammals
10.1038/s41586-024-08054-z · 2025 · External reference
Global production capacity of seasonal and pandemic influenza vaccines in 2023
10.1016/j.vaccine.2025.126839 · 2025 · External reference
Seasonal influenza vaccines
2009 · External reference
An overview of influenza H5 vaccines
2025 · External reference
Unresolved reference
External reference
Influenza vaccines: successes and continuing challenges
10.1093/infdis/jiab269 · 2021 · External reference
Unresolved reference
External reference
Unresolved reference
2022 · External reference
Research priorities for zoonotic and pandemic influenza vaccines: evidence and recommendations from the WHO public health research agenda for influenza (2024 update)
10.3390/vaccines13121206 · 2025 · External reference
Evaluating the broader impact of improved influenza vaccines: a full value of vaccine assessment approach
2026 · External reference
Influenza vaccine recommendations and coverage (2018–2023): a foundation for pandemic preparedness and response
10.1016/j.vaccine.2026.128391 · 2026 · External reference
Pathways to economically viable and sustainable vaccine manufacturing in LMICs
10.1016/j.vaccine.2026.128273 · 2026 · External reference
Unresolved reference
2025 · External reference
mRNA and next-generation vaccine platforms for pandemic influenza preparedness
10.3390/vaccines14030247 · 2026 · External reference
Unresolved reference
2025 · External reference
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
10.1016/s0140-6736(17)33293-2 · 2018 · External reference
Unresolved reference
External reference
Effectiveness of influenza vaccination to prevent severe disease: a systematic review and meta-analysis of test-negative design studies
10.1016/j.cmi.2025.09.023 · 2026 · External reference
Unresolved reference
External reference
The IFPMA IVS seasonal influenza vaccine dose distribution survey 2022–2023: evidence of the need for committed national investment in and uptake of seasonal influenza vaccination
10.1016/j.vaccine.2025.127747 · 2025 · External reference
High-dose vs standard-dose influenza vaccines in older adults: a meta-analysis
10.1001/jamanetworkopen.2026.14620 · 2026 · External reference
Importance and value of adjuvanted influenza vaccine in the care of older adults from a European perspective – a systematic review of recently published literature on real-world data
10.1016/j.vaccine.2022.04.019 · 2022 · External reference
Recent advances in the influenza virus vaccine landscape: a comprehensive overview of technologies and trials
2024 · External reference
Relative efficacy, effectiveness and safety of newer and/or enhanced seasonal influenza vaccines for the prevention of laboratory-confirmed influenza in individuals aged 18 years and over: update of a systematic review
10.1002/rmv.70020 · 2025 · External reference
Effectiveness of cell-based quadrivalent seasonal influenza vaccine: a systematic review and Meta-analysis
10.3390/vaccines11101607 · 2023 · External reference
A universal influenza vaccine: the strategic plan for the National Institute of Allergy and Infectious Diseases
10.1093/infdis/jiy103 · 2018 · External reference
Unresolved reference
2019 · External reference
Unresolved reference
External reference
Novel universal vaccines to mitigate emerging avian influenza viruses
2025 · External reference
Advancing influenza vaccines: a review of next-generation candidates and their potential for global health impact
10.1016/j.vaccine.2024.126408 · 2024 · External reference
Brief comparison of novel influenza vaccine design strategies
10.3390/vaccines13111164 · 2025 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Global funders consortium for universal influenza vaccine development
10.1016/j.vaccine.2018.11.037 · 2019 · External reference
Unresolved reference
External reference
A Research and Development (R&D) roadmap for influenza vaccines: looking toward the future
10.1016/j.vaccine.2021.08.010 · 2021 · External reference
Accomplishments and challenges in developing improved influenza vaccines: an evaluation of three years of progress toward the milestones of the influenza vaccines research and development roadmap
10.1016/j.vaccine.2025.127431 · 2025 · External reference
Tracking progress in universal influenza vaccine development
10.1016/j.coviro.2020.02.003 · 2020 · External reference
Funding the priorities of the influenza vaccines research and development roadmap: an evaluation of global investment
10.1016/j.vaccine.2025.127967 · 2026 · External reference
Meeting report: fourth correlates of protection for next generation influenza vaccines
10.1111/irv.70258 · 2026 · External reference
Exclusive: key US infectious-diseases centre to drop pandemic preparation
2026 · External reference
Confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era
10.1016/s0140-6736(23)00136-8 · 2023 · External reference
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID)
2026 · External reference
Building a fast response capability for emerging infectious diseases within the biomedical advanced research and development authority
10.1089/hs.2024.0074 · 2025 · External reference
Collaborative influenza vaccine innovation centers (CIVICs) program
10.1016/j.vaccine.2025.127118 · 2025 · External reference
Benefit-risk assessment of vaccines
10.1016/j.vaccine.2023.07.041 · 2024 · External reference
mRNA vaccines for infectious diseases — advances, challenges and opportunities
2024 · External reference
Harnessing the potential of mRNA vaccines against infectious diseases
10.1111/1751-7915.70212 · 2025 · External reference
Optimized seasonal influenza mRNA vaccine compositions demonstrate safety and enhanced immunogenicity in a phase 2 study
10.1080/21645515.2026.2694211 · 2026 · External reference
Efficacy and safety of an mRNA seasonal influenza vaccine in adults
10.1056/nejmoa2516491 · 2026 · External reference
Efficacy, immunogenicity, and safety of modified mRNA influenza vaccine
10.1056/nejmoa2416779 · 2025 · External reference
Vaccinology in the artificial intelligence era
10.1126/scitranslmed.adu3791 · 2025 · External reference
Prepare now for a potential H5N1 pandemic
10.1126/science.adw3278 · 2025 · External reference
Highly pathogenic avian influenza: pandemic preparedness for a scenario of high lethality with no vaccines
10.3389/fpubh.2025.1613869 · 2025 · External reference
De-risking vaccine development: lessons, challenges, and prospects
10.1038/s41541-025-01211-z · 2025 · External reference
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy
10.1038/s41541-024-00873-5 · 2024 · External reference
Development of an intranasal, universal influenza vaccine in an EU funded public-private partnership: the FLUniversal consortium
10.3389/fimmu.2025.1568778 · 2025 · External reference
Protecting the future of vaccine development amidst US funding withdrawal for mRNA vaccine research
2025 · External reference
Europe needs a sustainably funded influenza research and response network
10.1016/s1473-3099(25)00068-4 · 2025 · External reference
Strategic and scientific contributions of human challenge trials for vaccine development: facts versus fantasy
2023 · External reference
Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies – a stakeholder meeting report
10.1016/j.biologicals.2025.101818 · 2025 · External reference
Assessing AI’s cognitive abilities for scientific discovery in the field of systems vaccinology
10.1126/sciimmunol.adx1794 · 2025 · External reference
Transforming vaccinology
10.1016/j.cell.2024.07.021 · 2024 · External reference
T cells responses after vaccination: a regulatory perspective
10.3389/fimmu.2025.1584738 · 2025 · External reference
First among equals: the case for high-quality clinical data in influenza vaccines
10.1093/cid/ciaf290 · 2025 · External reference
Unresolved reference
2007 · External reference
Unresolved reference
2023 · External reference
From global insights to local action: bridging vaccine design and manufacturing gaps in H5N1 pandemic readiness
10.3390/vaccines14060519 · 2026 · External reference
Unpacking the mRNA supply chain: challenges and opportunities for global health
10.3390/vaccines14040324 · 2026 · External reference
Which virus will cause the next pandemic?
10.3390/v15010199 · 2023 · External reference
High-dose vs standard-dose influenza vaccines in older adults: a meta-analysis
10.1001/jamanetworkopen.2026.14620 · ExternalCitation · doi-reference
Relative efficacy, effectiveness and safety of newer and/or enhanced seasonal influenza vaccines for the prevention of laboratory-confirmed influenza in individuals aged 18 years and over: update of a systematic review
10.1002/rmv.70020 · ExternalCitation · doi-reference
Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies – a stakeholder meeting report
10.1016/j.biologicals.2025.101818 · ExternalCitation · doi-reference
Transforming vaccinology
10.1016/j.cell.2024.07.021 · ExternalCitation · doi-reference
Effectiveness of influenza vaccination to prevent severe disease: a systematic review and meta-analysis of test-negative design studies
10.1016/j.cmi.2025.09.023 · ExternalCitation · doi-reference
Tracking progress in universal influenza vaccine development
10.1016/j.coviro.2020.02.003 · ExternalCitation · doi-reference
Global funders consortium for universal influenza vaccine development
10.1016/j.vaccine.2018.11.037 · ExternalCitation · doi-reference
A Research and Development (R&D) roadmap for influenza vaccines: looking toward the future
10.1016/j.vaccine.2021.08.010 · ExternalCitation · doi-reference
Importance and value of adjuvanted influenza vaccine in the care of older adults from a European perspective – a systematic review of recently published literature on real-world data
10.1016/j.vaccine.2022.04.019 · ExternalCitation · doi-reference
Benefit-risk assessment of vaccines
10.1016/j.vaccine.2023.07.041 · ExternalCitation · doi-reference
Advancing influenza vaccines: a review of next-generation candidates and their potential for global health impact
10.1016/j.vaccine.2024.126408 · ExternalCitation · doi-reference
Global production capacity of seasonal and pandemic influenza vaccines in 2023
10.1016/j.vaccine.2025.126839 · ExternalCitation · doi-reference
Collaborative influenza vaccine innovation centers (CIVICs) program
10.1016/j.vaccine.2025.127118 · ExternalCitation · doi-reference
Accomplishments and challenges in developing improved influenza vaccines: an evaluation of three years of progress toward the milestones of the influenza vaccines research and development roadmap
10.1016/j.vaccine.2025.127431 · ExternalCitation · doi-reference
The IFPMA IVS seasonal influenza vaccine dose distribution survey 2022–2023: evidence of the need for committed national investment in and uptake of seasonal influenza vaccination
10.1016/j.vaccine.2025.127747 · ExternalCitation · doi-reference
Funding the priorities of the influenza vaccines research and development roadmap: an evaluation of global investment
10.1016/j.vaccine.2025.127967 · ExternalCitation · doi-reference
Pathways to economically viable and sustainable vaccine manufacturing in LMICs
10.1016/j.vaccine.2026.128273 · ExternalCitation · doi-reference
Influenza vaccine recommendations and coverage (2018–2023): a foundation for pandemic preparedness and response
10.1016/j.vaccine.2026.128391 · ExternalCitation · doi-reference
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
10.1016/s0140-6736(17)33293-2 · ExternalCitation · doi-reference
Confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era
10.1016/s0140-6736(23)00136-8 · ExternalCitation · doi-reference
Europe needs a sustainably funded influenza research and response network
10.1016/s1473-3099(25)00068-4 · ExternalCitation · doi-reference
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy
10.1038/s41541-024-00873-5 · ExternalCitation · doi-reference
De-risking vaccine development: lessons, challenges, and prospects
10.1038/s41541-025-01211-z · ExternalCitation · doi-reference
The global H5N1 influenza panzootic in mammals
10.1038/s41586-024-08054-z · ExternalCitation · doi-reference
Efficacy, immunogenicity, and safety of modified mRNA influenza vaccine
10.1056/nejmoa2416779 · ExternalCitation · doi-reference
Efficacy and safety of an mRNA seasonal influenza vaccine in adults
10.1056/nejmoa2516491 · ExternalCitation · doi-reference
Optimized seasonal influenza mRNA vaccine compositions demonstrate safety and enhanced immunogenicity in a phase 2 study
10.1080/21645515.2026.2694211 · ExternalCitation · doi-reference
Building a fast response capability for emerging infectious diseases within the biomedical advanced research and development authority
10.1089/hs.2024.0074 · ExternalCitation · doi-reference
First among equals: the case for high-quality clinical data in influenza vaccines
10.1093/cid/ciaf290 · ExternalCitation · doi-reference
Influenza vaccines: successes and continuing challenges
10.1093/infdis/jiab269 · ExternalCitation · doi-reference
2009 pandemic influenza a virus subtype H1N1 vaccination in Africa—successes and challenges
10.1093/infdis/jis535 · ExternalCitation · doi-reference
A universal influenza vaccine: the strategic plan for the National Institute of Allergy and Infectious Diseases
10.1093/infdis/jiy103 · ExternalCitation · doi-reference
Harnessing the potential of mRNA vaccines against infectious diseases
10.1111/1751-7915.70212 · ExternalCitation · doi-reference
Meeting report: fourth correlates of protection for next generation influenza vaccines
10.1111/irv.70258 · ExternalCitation · doi-reference
Prepare now for a potential H5N1 pandemic
10.1126/science.adw3278 · ExternalCitation · doi-reference
Assessing AI’s cognitive abilities for scientific discovery in the field of systems vaccinology
10.1126/sciimmunol.adx1794 · ExternalCitation · doi-reference
Vaccinology in the artificial intelligence era
10.1126/scitranslmed.adu3791 · ExternalCitation · doi-reference
Pandemic (H1N1) 2009: assessing the response
10.1503/cmaj.100900 · ExternalCitation · doi-reference
Development of an intranasal, universal influenza vaccine in an EU funded public-private partnership: the FLUniversal consortium
10.3389/fimmu.2025.1568778 · ExternalCitation · doi-reference
T cells responses after vaccination: a regulatory perspective
10.3389/fimmu.2025.1584738 · ExternalCitation · doi-reference
Highly pathogenic avian influenza: pandemic preparedness for a scenario of high lethality with no vaccines
10.3389/fpubh.2025.1613869 · ExternalCitation · doi-reference
Which virus will cause the next pandemic?
10.3390/v15010199 · ExternalCitation · doi-reference
Effectiveness of cell-based quadrivalent seasonal influenza vaccine: a systematic review and Meta-analysis
10.3390/vaccines11101607 · ExternalCitation · doi-reference
Brief comparison of novel influenza vaccine design strategies
10.3390/vaccines13111164 · ExternalCitation · doi-reference
Research priorities for zoonotic and pandemic influenza vaccines: evidence and recommendations from the WHO public health research agenda for influenza (2024 update)
10.3390/vaccines13121206 · ExternalCitation · doi-reference
mRNA and next-generation vaccine platforms for pandemic influenza preparedness
10.3390/vaccines14030247 · ExternalCitation · doi-reference
Unpacking the mRNA supply chain: challenges and opportunities for global health
10.3390/vaccines14040324 · ExternalCitation · doi-reference
From global insights to local action: bridging vaccine design and manufacturing gaps in H5N1 pandemic readiness
10.3390/vaccines14060519 · ExternalCitation · doi-reference
