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References from Prospective, randomized, placebo-controlled, multicenter, double-blind, parallel-group, registration field trial evaluating izenivetmab, a caninized anti-nerve growth factor monoclonal antibody, administered quarterly to dogs with naturally occurring osteoarthritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Risk factors for canine osteoarthritis and its predisposing arthropathies: A systemic review
10.3389/fvets.2020.00220 · 2020 · External reference
Strategies and challenges for the next generation of therapeutic antibodies
10.1038/nri2747 · 2010 · External reference
The canine orthopedic index. Step 1: devising the items
10.1111/j.1532-950x.2014.12142.x · 2014 · External reference
The canine orthopedic index. Step 2: psychometric testing
10.1111/j.1532-950x.2014.12141.x · 2014 · External reference
Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis
10.2460/ajvr.68.6.631 · 2007 · External reference
Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis
10.2460/javma.233.8.1278 · 2008 · External reference
The canine orthopedic index. Step 3: responsiveness testing
10.1111/j.1532-950x.2014.12162.x · 2014 · External reference
Unresolved reference
2017 · External reference
Power of treatment success definitions when the canine brief pain inventory is used to evaluate carprofen treatment for the control of pain and inflammation in dogs with osteoarthritis
10.2460/ajvr.74.12.1467 · 2013 · External reference
Non-steroidal anti-inflammatory drugs in the pharmacological management of osteoarthritis in the very old: Prescribe or proscribe?
10.1177/1759720x211022149 · 2021 · External reference
The number needed to treat: A clinically useful measure of treatment effect
10.1136/bmj.310.6977.452 · 1995 · External reference
A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis
10.1016/j.vaa.2021.08.001 · 2021 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Regression to the mean: Statistical bias can mislead interpretation in cartilage and osteoarthritis clinics and research
10.1177/19476035241293048 · 2024 · External reference
Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs
10.1038/s41598-024-52324-9 · 2024 · External reference
A noninferiority trial evaluating the efficacy of bedinvetmab compared to grapiprant for osteoarthritis-pain in dogs using force plate gait analysis
10.1038/s41598-026-37626-4 · 2026 · External reference
The present state of the art in expression, production and characterization of monoclonal antibodies
10.1007/s11030-015-9625-z · 2015 · External reference
Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats
10.1111/jvim.16291 · 2021 · External reference
Validation of a client-based clinical metrology instrument for the evaluation of canine elbow osteoarthritis
10.1111/j.1748-5827.2009.00765.x · 2009 · External reference
Psychometric testing of the Helsinki chronic pain index by completion of a questionnaire in Finnish by owners of dogs with chronic signs of pain caused by osteoarthritis
10.2460/ajvr.70.6.727 · 2009 · External reference
A randomised, parallel-group clinical trial comparing bedinvetmab to meloxicam for the management of canine osteoarthritis
10.3389/fvets.2025.1502218 · 2025 · External reference
Osteoarthritis. Joint anatomy, physiology, and pathobiology
10.1016/s0195-5616(97)50076-3 · 1997 · External reference
Nonsurgical management of osteoarthritis in dogs
10.1016/j.cvsm.2008.08.001 · 2008 · External reference
Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs
10.1016/j.tvjl.2021.105733 · 2021 · External reference
Spontaneous dog osteoarthritis – a One Medicine vision
10.1038/s41584-019-0202-1 · 2019 · External reference
A blinded, randomized, placebo-controlled, dose determination trial of lokivetmab (ZTS-00103289), a caninized, anti-canine IL-31 monoclonal antibody in client owned dogs with atopic dermatitis
10.1111/vde.12376 · 2016 · External reference
A blinded, randomized, placebo-controlled trial of the safety of lokivetmab (ZTS-00103289), a caninized anti-canine IL-31 monoclonal antibody in client-owned dogs with atopic dermatitis
10.1111/vde.12364 · 2016 · External reference
A prospective, randomized, double-blind, placebo-controlled multisite, parallel-group field study in dogs with osteoarthritis conducted in the United States of America evaluating bedinvetmab, a canine anti-nerve growth factor monoclonal antibody
10.1016/j.vaa.2023.06.003 · 2023 · External reference
Evaluation of clinical metrology instrument in dogs with osteoarthritis
10.1111/jvim.13923 · 2016 · External reference
A prospective, randomized, masked, placebo-controlled multisite clinical study of grapiprant, an EP4 prostaglandin receptor antagonist (PRA), in dogs with osteoarthritis
10.1111/jvim.13948 · 2016 · External reference
Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis
10.1186/1746-6148-8-162 · 2012 · External reference
Clinical assessment of osteoarthritis pain: Contemporary scenario, challenges, and future perspectives
10.1007/s40122-024-00592-8 · 2024 · External reference
Unresolved reference
2019 · External reference
Evaluation of construct and criterion validity for the 'Liverpool Osteoarthritis in Dogs' (LOAD) clinical metrology instrument and comparison to two other instruments
10.1371/journal.pone.0058125 · 2013 · External reference
Linguistic validation of the canine brief pain inventory (CBPI) for global use
10.3389/fvets.2021.769112 · 2021 · External reference
Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests
10.1111/jsap.13500 · 2022 · External reference