Research graph
References from TRIM28 induces the PDCoV NS6 degradation through the ubiquitin proteasome pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Characterization of a Pathogenic Full-Length cDNA clone and transmission model for porcine epidemic diarrhea virus strain PC22A
10.1128/mbio.01451-15 · 2016 · External reference
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress
10.1016/j.devcel.2021.10.006 · 2021 · External reference
TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination
10.1016/j.jbc.2023.104660 · 2023 · External reference
Intracellular dynamics of the ubiquitin-proteasome-system
10.12688/f1000research.6835.1 · 2015 · External reference
The Host E3-ubiquitin Ligase TRIM28 Impedes Viral Protein GP4 ubiquitination and promotes PRRSV Replication
10.3390/ijms241310965 · 2023 · External reference
The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes
10.1016/j.vetmic.2012.10.032 · 2013 · External reference
Porcine Deltacoronavirus Accessory Protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I/MDA5 to Double-Stranded RNA
10.1128/jvi.00712-18 · 2018 · External reference
Porcine deltacoronavirus accessory protein NS7a Antagonizes IFN-β production by competing with TRAF3 and IRF3 for Binding to IKKε
10.3389/fcimb.2020.00257 · 2020 · External reference
Porcine deltacoronavirus accessory protein NS6 harnesses VPS35-mediated retrograde trafficking to facilitate efficient viral infection
10.1128/jvi.00957-23 · 2023 · External reference
Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
10.3389/fcimb.2023.1166839 · 2023 · External reference
KAP1 protein: an enigmatic master regulator of the genome
10.1074/jbc.r111.252569 · 2011 · External reference
Structures of a deltacoronavirus spike protein bound to porcine and human receptors
10.1038/s41467-022-29062-5 · 2022 · External reference
The ubiquitin E3 ligase TRIM21 suppresses type I interferon signaling via STING degradation and ameliorates systemic autoimmunity
10.1038/s12276-025-01490-5 · 2025 · External reference
Porcine deltacoronaviruses: origin, evolution, cross-species transmission and zoonotic potential
10.3390/pathogens11010079 · 2022 · External reference
Independent infections of porcine deltacoronavirus among Haitian children
10.1038/s41586-021-04111-z · 2021 · External reference
TRIM28 promotes porcine epidemic diarrhea virus replication by mitophagy-mediated inhibition of the JAK-STAT1 pathway
2024 · External reference
Porcine deltacoronavirus NS7a antagonizes JAK/STAT pathway by inhibiting the interferon-stimulated gene factor 3 (ISGF3) formation
10.1016/j.ijbiomac.2024.130693 · 2024 · External reference
Red recombination enables a wide variety of markerless manipulation of porcine epidemic diarrhea virus genome to generate recombinant virus
2023 · External reference
TRIM7 suppresses transmissible gastroenteritis virus replication by targeting the degradation of N protein and activating RIG-I-mediated type I IFN antiviral response
10.1186/s13567-025-01610-z · 2025 · External reference
Diversity of degradation signals in the ubiquitin-proteasome system
10.1038/nrm2468 · 2008 · External reference
E3 ubiquitin ligases: structural diversity, dysregulation in disease, and their emerging role in targeted therapeutic strategies
10.3389/fmolb.2026.1745654 · 2026 · External reference
SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7
10.7554/elife.102277.4 · 2025 · External reference
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2
10.1016/j.cellsig.2021.110064 · 2021 · External reference
Immune evasion strategies of Seneca Valley virus: mechanisms of host innate immune suppression
2025 · External reference
Seneca Valley virus 3C protease targets TRIM32 for cleavage to antagonize its antiviral effects
10.1128/jvi.00590-25 · 2025 · External reference
Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas
10.1186/s12977-021-00584-y · 2021 · External reference
Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design
10.1080/22221751.2019.1701391 · 2020 · External reference
Deletion of NS6 attenuates Porcine Deltacoronavirus pathogenicity without compromising immunogenicity
10.1016/j.vetmic.2026.110996 · 2026 · External reference
