Research graph
References from Type I Interferon Mitigates ZIKV-Induced Neuroinflammation and Cell Death in the Central Nervous System. Local targets link to admitted publications; unresolved targets remain external evidence.
ZIKV: Epidemiology, infection mechanism and current therapeutics
10.3389/fitd.2022.1059283 · 2023 · External reference
Zika Virus Infection and Development of Drug Therapeutics
10.3390/applmicrobiol2040059 · 2022 · External reference
Pathogenesis of Zika Virus Infection
10.1146/annurev-pathmechdis-031521-034739 · 2023 · External reference
Targeting Type I Interferon Induction and Signaling: How Zika Virus Escapes from Host Innate Immunity
10.7150/ijbs.83056 · 2023 · External reference
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway
10.1007/s00018-020-03671-z · 2021 · External reference
A Mouse Model of Zika Virus Pathogenesis
10.1016/j.chom.2016.03.010 · 2016 · External reference
Characterization of a Novel Murine Model to Study Zika Virus
10.4269/ajtmh.16-0111 · 2016 · External reference
Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice
10.1038/s41564-017-0060-z · 2018 · External reference
Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells
10.1186/s12974-019-1566-5 · 2019 · External reference
Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
10.1016/j.ebiom.2016.11.017 · 2016 · External reference
Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler’s virus
10.4049/jimmunol.142.8.2677 · 1989 · External reference
Ter Meulen V. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
10.1073/pnas.88.16.7438 · 1991 · External reference
Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved
10.3389/fimmu.2022.773191 · 2022 · External reference
Alpha/Beta Interferon Protects against Lethal West Nile Virus Infection by Restricting Cellular Tropism and Enhancing Neuronal Survival
10.1128/jvi.79.21.13350-13361.2005 · 2005 · External reference
Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression
10.1016/j.chom.2015.06.007 · 2015 · External reference
The iNOS Activity During an Immune Response Controls the CNS Pathology in Experimental Autoimmune Encephalomyelitis
10.3389/fimmu.2019.00710 · 2019 · External reference
Proinflammatory Cytokines and Chemokines in Humans with Japanese Encephalitis
10.1086/423328 · 2004 · External reference
Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis
10.1002/glia.20474 · 2007 · External reference
Nitric oxide and the immune response
10.1038/ni1001-907 · 2001 · External reference
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
10.1038/nrn2214 · 2007 · External reference
Nitric oxide and virus infection
10.1046/j.1365-2567.2000.00142.x · 2000 · External reference
Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages
10.1186/1742-2094-9-246 · 2012 · External reference
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
10.1038/s41598-017-17765-5 · 2018 · External reference
Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3
10.1016/j.stem.2016.04.014 · 2016 · External reference
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
10.1073/pnas.1618029113 · 2016 · External reference
The Neurobiology of Zika Virus
10.1016/j.neuron.2016.11.031 · 2016 · External reference
Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia
10.1186/1742-2094-4-11 · 2007 · External reference
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production
10.1172/jci136824 · 2021 · External reference
SARS-CoV-2 Infection of Microglia Elicits Proinflammatory Activation and Apoptotic Cell Death
10.1128/spectrum.01091-22 · 2022 · External reference
Restriction of Zika Virus Replication in Human Monocyte-Derived Macrophages by Pro-Inflammatory (M1) Polarization
10.3390/ijms26030951 · 2025 · External reference
Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection
10.1172/jci88720 · 2017 · External reference
Pathogenesis and Manifestations of Zika Virus-Associated Ocular Diseases
10.3390/tropicalmed7060106 · 2022 · External reference
Zika & heart: A systematic review
10.1016/j.tcm.2020.11.003 · 2022 · External reference
Zika Induces Human Placental Damage and Inflammation
10.3389/fimmu.2020.02146 · 2020 · External reference
Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice
10.1128/jvi.01006-23 · 2023 · External reference
