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References from Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming. Local targets link to admitted publications; unresolved targets remain external evidence.
Bioengineered human tissue regeneration and repair using endogenous stem cells
2023 · External reference
Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
10.1111/acel.70268 · 2025 · External reference
The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming
10.1016/j.devcel.2015.09.005 · 2015 · External reference
Activation of fetal-like molecular programs during regeneration in the intestine and beyond
10.1016/j.stem.2024.05.009 · 2024 · External reference
Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
10.1038/s41586-019-1154-y · 2019 · External reference
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration
10.1016/j.stem.2020.06.020 · 2020 · External reference
Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
10.1016/j.stem.2023.01.009 · 2023 · External reference
TGFB1 induces fetal reprogramming and enhances intestinal regeneration
10.1016/j.stem.2023.09.015 · 2023 · External reference
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
10.1038/s41586-020-2166-3 · 2020 · External reference
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium
10.15252/embj.201694660 · 2017 · External reference
Reprogramming to recover youthful epigenetic information and restore vision
10.1038/s41586-020-2975-4 · 2020 · External reference
In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
10.1038/s41467-021-23353-z · 2021 · External reference
Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice
10.1126/science.abg5159 · 2021 · External reference
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
10.1016/j.celrep.2022.110730 · 2022 · External reference
Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction
10.1126/sciadv.adi8454 · 2023 · External reference
Single-short partial reprogramming of the endothelial cells decreases blood pressure via attenuation of EndMT in hypertensive mice
10.1161/circresaha.124.324909 · 2025 · External reference
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
10.1038/s43587-022-00183-2 · 2022 · External reference
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
10.1038/ng.722 · 2011 · External reference
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver
10.1038/nature14863 · 2015 · External reference
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
10.1016/j.stem.2019.11.001 · 2020 · External reference
Signaling pathways of liver regeneration: Biological mechanisms and implications
2024 · External reference
Liver zonation, revisited
10.1002/hep.32408 · 2022 · External reference
The spatiotemporal program of zonal liver regeneration following acute injury
10.1016/j.stem.2022.04.008 · 2022 · External reference
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
10.1038/nature23015 · 2017 · External reference
Adult hepatocytes are generated by self-duplication rather than stem cell differentiation
10.1016/j.stem.2014.06.003 · 2014 · External reference
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
10.1016/j.cell.2015.07.026 · 2015 · External reference
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
10.1038/s41586-018-0004-7 · 2018 · External reference
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
10.1016/j.stem.2019.04.004 · 2019 · External reference
Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes
10.1016/j.stem.2014.09.008 · 2014 · External reference
A reprogrammable mouse strain from gene-targeted embryonic stem cells
10.1038/nmeth.1409 · 2010 · External reference
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
10.1038/s43587-023-00528-5 · 2023 · External reference
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
10.1016/j.cell.2016.11.052 · 2016 · External reference
Aneuploidy, polyploidy and ploidy reversal in the liver
10.1016/j.semcdb.2013.01.003 · 2013 · External reference
Maintenance of primary hepatocyte functions in vitro by inhibiting mechanical tension-induced YAP activation
10.1016/j.celrep.2019.10.128 · 2019 · External reference
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure
10.1038/s41419-020-2334-2 · 2020 · External reference
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications
10.1016/j.taap.2013.03.026 · 2013 · External reference
Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway
10.7150/ijbs.12118 · 2015 · External reference
Multimodal decoding of human liver regeneration
10.1038/s41586-024-07376-2 · 2024 · External reference
Liver regeneration
10.1002/jcp.21172 · 2007 · External reference
Zonation of hepatic cytochrome P-450 expression and regulation
10.1042/bj3290017 · 1998 · External reference
The stem cell niche of human livers: symmetry between development and regeneration
10.1002/hep.22516 · 2008 · External reference
Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans
10.1002/hep.24122 · 2011 · External reference
NicheNet: modeling intercellular communication by linking ligands to target genes
10.1038/s41592-019-0667-5 · 2020 · External reference
Oxidative Stress Drives Liver Failure During In Vivo Partial Reprogramming
10.1016/j.mocell.2026.100378 · 2026 · External reference
Cellular rejuvenation protects neurons from inflammation-mediated cell death
10.1016/j.celrep.2025.115298 · 2025 · External reference
Lipid nanoparticles for mRNA delivery
10.1038/s41578-021-00358-0 · 2021 · External reference
Galactosylated lipidoid nanoparticles for delivery of small interfering RNA to inhibit hepatitis C viral replication in vivo
10.1002/adhm.201600416 · 2016 · External reference
Asialoglycoprotein receptor mediated hepatocyte targeting—Strategies and applications
10.1016/j.jconrel.2015.02.022 · 2015 · External reference
LPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy
10.1038/s41419-022-04715-x · 2022 · External reference
SOX9 promotes hepatocyte proliferation via upregulating TGF-α expression during liver regeneration
10.1007/s12072-025-10940-1 · 2026 · External reference
AAVvector-mediated in vivo reprogramming into pluripotency
10.1038/s41467-018-05059-x · 2018 · External reference
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
10.1038/mt.2010.85 · 2010 · External reference
Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs
10.1038/s41578-022-00529-7 · 2023 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Array programming with NumPy
10.1038/s41586-020-2649-2 · 2020 · External reference
Unresolved reference
External reference
Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data
10.1016/j.cels.2018.11.005 · 2019 · External reference
Deep generative modeling for single-cell transcriptomics
10.1038/s41592-018-0229-2 · 2018 · External reference
Efficient integration of heterogeneous single-cell transcriptomes using Scanorama
10.1038/s41587-019-0113-3 · 2019 · External reference
SEACells: Inference of transcriptional and epigenomic cellular states from single-cell genomics data
10.1038/s41587-023-01716-9 · 2023 · External reference
scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data
10.1093/bioinformatics/btac746 · 2023 · External reference
GSEApy: a comprehensive package for performing gene set enrichment analysis in Python
10.1093/bioinformatics/btac757 · 2023 · External reference
Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
10.7554/elife.43803 · 2019 · External reference
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
10.1038/nprot.2008.80 · 2008 · External reference
Protocol for Primary Mouse Hepatocyte Isolation
10.1016/j.xpro.2020.100086 · 2020 · External reference
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons
10.1038/s41551-018-0260-8 · 2018 · External reference
Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
10.1016/j.jcmgh.2020.07.012 · 2021 · External reference
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
10.1016/j.isci.2021.103233 · 2021 · External reference
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis
10.1126/scitranslmed.adc9653 · 2023 · External reference
Functional interpretation of single cell similarity maps
10.1038/s41467-019-12235-0 · 2019 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference