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References from Multi-omics-driven personalized management of advanced HCC. Local targets link to admitted publications; unresolved targets remain external evidence.
Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
2021 · External reference
A global view of hepatocellular carcinoma: trends, risk, prevention and management
10.1038/s41575-019-0186-y · 2019 · External reference
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
10.1056/nejmoa1915745 · 2020 · External reference
Immunotherapies for hepatocellular carcinoma
10.1038/s41571-021-00573-2 · 2022 · External reference
New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials
10.7150/ijbs.70691 · 2022 · External reference
Development of Immunotherapy Combination Strategies in Cancer
10.1158/2159-8290.cd-20-1209 · 2021 · External reference
Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence
10.1016/j.ctrv.2018.11.002 · 2019 · External reference
Transarterial chemoembolization in hepatocellular carcinoma treatment: Barcelona clinic liver cancer staging system
10.3748/wjg.v21.i36.10327 · 2015 · External reference
Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials
10.1148/radiol.2241011262 · 2002 · External reference
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial
10.1136/gutjnl-2019-318934 · 2020 · External reference
Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization
10.4049/jimmunol.178.3.1914 · 2007 · External reference
Radiofrequency thermal ablation for hepatocellular carcinoma stimulates autologous NK-cell response
10.1053/j.gastro.2009.12.051 · 2010 · External reference
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
10.1038/s41575-020-00395-0 · 2021 · External reference
EMERALD-1: A phase 3, randomized, placebo-controlled study of transarterial chemoembolization combined with durvalumab with or without bevacizumab in participants with unresectable hepatocellular carcinoma eligible for embolization
10.1200/jco.2024.42.3_suppl.lba432 · 2024 · External reference
Hepatocellular carcinoma: diagnosis, treatment algorithms, and imaging appearance after transarterial chemoembolization
2018 · External reference
Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny
10.1136/gutjnl-2021-324339 · 2022 · External reference
Immunohistochemical Identification of Ito Cells and Their Myofibroblastic Transformation in Adult Human Liver
10.1007/bf00194608 · 1994 · External reference
Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
10.1016/j.cell.2020.07.005 · 2020 · External reference
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
10.1038/nmeth.4391 · 2017 · External reference
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
10.1016/j.cell.2020.10.021 · 2020 · External reference
Organization of the human intestine at single-cell resolution
10.1038/s41586-023-05915-x · 2023 · External reference
Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma
10.1016/j.cell.2021.12.023 · 2022 · External reference
The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story
10.1111/jth.12225 · 2013 · External reference
The role of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
10.1016/j.bbadis.2016.11.006 · 2017 · External reference
Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
10.1016/j.cell.2020.07.019 · 2020 · External reference
Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue
10.1073/pnas.1111048108 · 2011 · External reference
11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity
10.1038/84701 · 2001 · External reference
Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
10.3389/fimmu.2020.02002 · 2020 · External reference
Robust decomposition of cell type mixtures in spatial transcriptomics
10.1038/s41587-021-00830-w · 2022 · External reference
Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress
10.3390/antiox12081567 · 2023 · External reference
cGAS in action: Expanding roles in immunity and inflammation
10.1126/science.aat8657 · 2019 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer
10.1158/2159-8290.cd-19-0761 · 2020 · External reference
STING mediates nuclear PD-L1 targeting-induced senescence in cancer cells
10.1038/s41419-022-05217-6 · 2022 · External reference
Radiation Therapy Promotes Hepatocellular Carcinoma Immune Cloaking via PD-L1 Upregulation Induced by cGAS-STING Activation
10.1016/j.ijrobp.2021.12.162 · 2022 · External reference
Trial watch: STING agonists in cancer therapy
2020 · External reference
Biomarkers for immunotherapy of hepatocellular carcinoma
10.1038/s41571-023-00816-4 · 2023 · External reference
NicheNet: modeling intercellular communication by linking ligands to target genes
10.1038/s41592-019-0667-5 · 2020 · External reference
The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis
10.1074/jbc.m112.348946 · 2012 · External reference
Chemokine-like functions of MIF in atherosclerosis
10.1007/s00109-008-0334-2 · 2008 · External reference
Tumor-specific T cells support chemokine-driven spatial organization of intratumoral immune microaggregates needed for long survival
10.1136/jitc-2021-004346 · 2022 · External reference
ATF3 represses PPARgamma expression and inhibits adipocyte differentiation
10.1016/j.bbrc.2014.10.028 · 2014 · External reference
Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis
10.7554/elife.43922 · 2019 · External reference
Nuclear receptor repression: regulatory mechanisms and physiological implications
10.1016/s1877-1173(09)87007-5 · 2009 · External reference
EZH2-mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARgamma
10.1111/cpr.13072 · 2021 · External reference
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
10.1093/nar/gkq227 · 2010 · External reference
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
10.1038/nature02583 · 2004 · External reference
The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor gamma requires G protein pathway suppressor 2
10.1074/jbc.m114.598797 · 2015 · External reference
Coactivators in PPAR-Regulated Gene Expression
10.1155/2010/250126 · 2010 · External reference
PPAR gamma Regulates Genes Involved in Triacylglycerol Synthesis and Secretion in Mammary Gland Epithelial Cells of Dairy Goats
10.1155/2013/310948 · 2013 · External reference
LncRNA TINCR/microRNA-107/CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis
10.1515/hsz-2018-0236 · 2019 · External reference
PPAR-beta/delta activation promotes phospholipid transfer protein expression
10.1016/j.bcp.2015.01.016 · 2015 · External reference
Bergenin, a PPARgamma agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis
10.1038/s41401-021-00717-1 · 2022 · External reference
Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-alpha activation
10.1017/s0007114511002777 · 2012 · External reference
Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis
10.1016/j.bbadis.2013.06.001 · 2013 · External reference
ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis
10.3390/ijms20112700 · 2019 · External reference
Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH)
10.1080/13543784.2020.1668375 · 2020 · External reference
Network classification with applications to brain connectomics
2019 · External reference
Automatic prediction of hepatic arterial infusion chemotherapy response in advanced hepatocellular carcinoma with deep learning radiomic nomogram
10.1007/s00330-023-09953-x · 2023 · External reference
Deep learning nomogram based on Gd-EOB-DTPA MRI for predicting early recurrence in hepatocellular carcinoma after hepatectomy
10.1007/s00330-023-09419-0 · 2023 · External reference
Predictive value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in advanced hepatocellular carcinoma patients treated with anti-PD-1 therapy
10.1002/cam4.3135 · 2020 · External reference
Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
10.1016/j.jhep.2023.01.011 · 2023 · External reference
An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice
10.1002/hep.30528 · 2019 · External reference
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
10.1038/s41587-021-01094-0 · 2022 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis
10.1016/j.cell.2015.05.047 · 2015 · External reference
Comprehensive Integration of Single-Cell Data
10.1016/j.cell.2019.05.031 · 2019 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
The nf-core framework for community-curated bioinformatics pipelines
10.1038/s41587-020-0439-x · 2020 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Modified RECIST (mRECIST) assessment for hepatocellular carcinoma
10.1055/s-0030-1247132 · 2010 · External reference
Surrogate variable analysis using partial least squares (SVA-PLS) in gene expression studies
10.1093/bioinformatics/bts022 · 2012 · External reference
Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection
10.1038/s41398-020-0831-9 · 2020 · External reference
Convex formulation for multi-task L1-L2-and LS-SVMs
10.1016/j.neucom.2021.01.137 · 2021 · External reference
