Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Disruption of the Nav1.8/Ankyrin-3 interaction in nociceptors reduces pathological pain-like behaviors in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
What is this thing called pain?
10.1172/jci45178 · 2010 · External reference
Pain: an overview
10.1016/s0140-6736(99)01311-2 · 1999 · External reference
Management of chronic pain
10.1016/s0140-6736(99)04088-x · 1999 · External reference
Cognitive and emotional control of pain and its disruption in chronic pain
10.1038/nrn3516 · 2013 · External reference
Mechanisms of Neuropathic Pain
10.1016/j.neuron.2006.09.021 · 2006 · External reference
Neuropathic Pain: From Mechanisms to Treatment
10.1152/physrev.00045.2019 · 2021 · External reference
Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review
10.1016/j.pain.2011.10.028 · 2012 · External reference
Angiotensin receptors and neuropathic pain
10.1097/pr9.0000000000000869 · 2021 · External reference
Supraspinal nociceptive networks in neuropathic pain after spinal cord injury
10.1002/hbm.25401 · 2021 · External reference
Macrophages protect against sensory axon loss in peripheral neuropathy
10.1038/s41586-024-08535-1 · 2025 · External reference
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain
10.1038/s41590-024-01857-2 · 2024 · External reference
Targeting sodium channels — challenges for acute pain and the leap to chronic pain
10.1038/s41582-025-01127-1 · 2025 · External reference
Mechanism-based nonopioid analgesic targets
10.1172/jci191346 · 2025 · External reference
The neuropathic pain: An overview of the current treatment and future therapeutic approaches
10.1177/2058738419838383 · 2019 · External reference
Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective NaV1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain
10.1007/s40122-024-00697-0 · 2025 · External reference
Virtual Reality Assisted Non-Pharmacological Treatments in Chronic Pain Management: A Systematic Review and Quantitative Meta-Analysis
10.3390/ijerph19074071 · 2022 · External reference
Virtual Reality interventions for acute and chronic pain management
10.1016/j.biocel.2019.105568 · 2019 · External reference
Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis
10.1016/s1474-4422(25)00068-7 · 2025 · External reference
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief
10.1517/14728222.2016.1162295 · 2016 · External reference
The Role of Voltage-Gated Sodium Channels in Pain Signaling
10.1152/physrev.00052.2017 · 2019 · External reference
The physiological function of different voltage-gated sodium channels in pain
10.1038/s41583-021-00444-w · 2021 · External reference
Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas
10.1186/1744-8069-9-52 · 2013 · External reference
Prostaglandin E2 Promotes Nav1.8 Trafficking via Its Intracellular RRR Motif Through the Protein Kinase A Pathway
10.1111/j.1600-0854.2009.01027.x · 2010 · External reference
Magi-1 scaffolds NaV1.8 and Slack KNa channels in dorsal root ganglion neurons regulating excitability and pain
10.1096/fj.201802454rr · 2019 · External reference
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
10.1073/pnas.0611364104 · 2007 · External reference
Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain
10.1097/j.pain.0000000000003470 · 2025 · External reference
Contribution of Nav1.8 Sodium Channels to Action Potential Electrogenesis in DRG Neurons
10.1152/jn.2001.86.2.629 · 2001 · External reference
Roles of Tetrodotoxin (TTX)-Sensitive Na+ Current, TTX-Resistant Na+ Current, and Ca2+ Current in the Action Potentials of Nociceptive Sensory Neurons
10.1523/jneurosci.22-23-10277.2002 · 2002 · External reference
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
10.1085/jgp.202413596 · 2024 · External reference
Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets
10.3389/fpain.2021.750583 · 2021 · External reference
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
10.1056/nejmoa2209870 · 2023 · External reference
Targeting a Peripheral Sodium Channel to Treat Pain
10.1056/nejme2305708 · 2023 · External reference
Ankyrin-G Regulates Inactivation Gating of the Neuronal Sodium Channel, Nav1.6
10.1152/jn.01264.2005 · 2006 · External reference
Ankyrin-G Directly Binds to Kinesin-1 to Transport Voltage-Gated Na+ Channels into Axons
10.1016/j.devcel.2013.11.023 · 2014 · External reference
Inflammation differentially controls transport of depolarizing Nav versus hyperpolarizing Kv channels to drive rat nociceptor activity
10.1073/pnas.2215417120 · 2023 · External reference
Voltage-gated sodium channels assemble and gate as dimers
10.1038/s41467-017-02262-0 · 2017 · External reference
Modulation of Nav1.7 and Nav1.8 Peripheral Nerve Sodium Channels by Protein Kinase A and Protein Kinase C
10.1152/jn.00676.2003 · 2004 · External reference
The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the beta3 subunit
10.1242/jcs.026856 · 2008 · External reference
Membrane Domains Based on Ankyrin and Spectrin Associated with Cell–Cell Interactions
10.1101/cshperspect.a003012 · 2009 · External reference
Targeting and Stability of Na/Ca Exchanger 1 in Cardiomyocytes Requires Direct Interaction with the Membrane Adaptor Ankyrin-B∗
10.1074/jbc.m607096200 · 2007 · External reference
Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons
10.1007/s00429-012-0443-0 · 2013 · External reference
Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
10.7554/elife.52373 · 2020 · External reference
Voltage-gated Nav channel targeting in the heart requires an ankyrin-G–dependent cellular pathway
10.1083/jcb.200710107 · 2008 · External reference
Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly
10.1073/pnas.1909989116 · 2019 · External reference
Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors
10.1073/pnas.1417989112 · 2015 · External reference
Giant ankyrin-B suppresses stochastic collateral axon branching through direct interaction with microtubules
10.1083/jcb.201910053 · 2020 · External reference
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A
10.7554/elife.69815 · 2021 · External reference
A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion
10.1016/j.neuron.2008.02.017 · 2008 · External reference
An Ancient Role for Giant Ankyrins in Axon Initial Segment Organization
10.1016/j.bpj.2016.11.880 · 2017 · External reference
An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier
10.1523/jneurosci.5434-11.2012 · 2012 · External reference
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
10.1073/pnas.0403711101 · 2004 · External reference
Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP
10.1038/s41380-018-0308-x · 2020 · External reference
Tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 constitutively interacts with ankyrin G
10.1111/jnc.12785 · 2014 · External reference
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia
10.1126/sciadv.adj9173 · 2024 · External reference
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
10.1126/scitranslmed.abj8186 · 2022 · External reference
Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
10.1038/s41467-021-26100-6 · 2021 · External reference
Protein kinase A–induced internalization of Slack channels from the neuronal membrane occurs by adaptor protein-2/clathrin–mediated endocytosis
10.1074/jbc.m117.804716 · 2017 · External reference
Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In
10.1523/jneurosci.18-24-10345.1998 · 1998 · External reference
Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons
10.3389/fphys.2023.959660 · 2023 · External reference
A HIERARCHY OF ANKYRIN/SPECTRIN COMPLEXES CLUSTERS SODIUM CHANNELS AT NODES OF RANVIER
10.1038/nn.3859 · 2014 · External reference
Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice
10.1083/jcb.114.6.1243 · 1991 · External reference
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain
10.1016/j.neuron.2014.12.065 · 2015 · External reference
Identifying the function of the NMDA NR1 C2 subunit through its interaction with Magi-2 during inflammatory pain
2024 · External reference
Structural basis of diverse membrane target recognitions by ankyrins
10.7554/elife.04353 · 2014 · External reference
Unresolved reference
External reference
Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions
10.7554/elife.29150 · 2017 · External reference
A genetically defined injured C-fibre nociceptor associated with neuromas drives chronic spontaneous neuropathic pain
2026 · External reference
Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice
10.1177/2049463720912496 · 2020 · External reference
Gabapentin for chronic neuropathic pain and fibromyalgia in adults
2014 · External reference
Gabapentin: pharmacology and its use in pain management
10.1046/j.0003-2409.2001.02399.x · 2002 · External reference
Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms
10.1083/jcb.200612012 · 2007 · External reference
The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment
10.1016/j.bbrc.2021.09.017 · 2021 · External reference
Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In
10.1016/j.neuron.2019.03.005 · 2019 · External reference
Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system
10.1016/s0169-328x(96)00241-0 · 1997 · External reference
Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
10.1152/jn.1994.72.1.466 · 1994 · External reference
Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons
10.1523/jneurosci.0058-22.2022 · 2022 · External reference
CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Nav1.8
10.1016/j.mcn.2004.11.007 · 2005 · External reference
Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain
10.1172/jci68996 · 2013 · External reference
Calmodulin Regulates Current Density and Frequency-Dependent Inhibition of Sodium Channel Nav1.8 in DRG Neurons
10.1152/jn.00854.2005 · 2006 · External reference
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1
10.1083/jcb.200204010 · 2002 · External reference
Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G
10.1083/jcb.200805169 · 2008 · External reference
Ankyrin-G Inhibits Endocytosis of Cadherin Dimers
10.1074/jbc.m115.648386 · 2016 · External reference
Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis
10.1126/sciadv.1500301 · 2015 · External reference
Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas
10.1002/ana.21527 · 2008 · External reference
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain
10.1016/j.jocn.2003.09.023 · 2004 · External reference
Isolation of Somatic Na+ Currents by Selective Inactivation of Axonal Channels with a Voltage Prepulse
10.1523/jneurosci.6136-09.2010 · 2010 · External reference
The PRIDE database at 20 years: 2025 update
10.1093/nar/gkae1011 · 2024 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney
10.1371/journal.pone.0142687 · 2016 · External reference
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity
10.1038/s41590-019-0559-y · 2020 · External reference
Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner
10.1038/s41598-024-67793-1 · 2024 · External reference
Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration
10.1038/s41467-025-58303-6 · 2025 · External reference
Up–Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds
10.3389/fphar.2018.00433 · 2018 · External reference
Automated preclinical detection of mechanical pain hypersensitivity and analgesia
10.1097/j.pain.0000000000002680 · 2022 · External reference
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks
10.1016/j.celrep.2025.116494 · 2025 · External reference
Data Processing Pipeline for Mammalian Proteome Dynamics Studies Using Stable Isotope Metabolic Labeling
10.1074/mcp.m111.010728 · 2011 · External reference
Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching
10.1021/ac9810516 · 1999 · External reference
