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References from Genetic Association between MMP9 and Choroidal Neovascularization in Age-Related Macular Degeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
A prospective study of cigarette smoking and age-related macular degeneration in women
10.1001/jama.1996.03540140029022 · 1996 · External reference
A prospective study of cigarette smoking and risk of age-related macular degeneration in men
10.1001/jama.1996.03540140035023 · 1996 · External reference
Obesity, lutein metabolism, and age-related macular degeneration: a web of connections
10.1111/j.1753-4887.2005.tb00105.x · 2005 · External reference
Age-related macular degeneration-clinical review and genetics update
10.1111/cge.12206 · 2013 · External reference
Dietary fat and risk for advanced age-related macular degeneration
10.1001/archopht.119.8.1191 · 2001 · External reference
Complement factor H polymorphism in age-related macular degeneration
10.1126/science.1109557 · 2005 · External reference
Complement factor H polymorphism and age-related macular degeneration
10.1126/science.1110189 · 2005 · External reference
Complement factor H variant increases the risk of age-related macular degeneration
10.1126/science.1110359 · 2005 · External reference
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
10.1073/pnas.0501536102 · 2005 · External reference
HTRA1 promoter polymorphism in wet age-related macular degeneration
10.1126/science.1133807 · 2006 · External reference
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
10.1126/science.1133811 · 2006 · External reference
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
10.1038/ng.3448 · 2016 · External reference
Genome-wide analysis of disease progression in age-related macular degeneration
10.1093/hmg/ddy002 · 2018 · External reference
MMP9 gene polymorphism is not associated with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration in a Chinese Han population
10.3109/13816810.2014.952832 · 2014 · External reference
MMP-9-hemopexin domain hampers adhesion and migration of colorectal cancer cells
2007 · External reference
Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration
10.1097/iae.0000000000000263 · 2015 · External reference
Decreased thickness and integrity of the macular elastic layer of Bruch’s membrane correspond to the distribution of lesions associated with age-related macular degeneration
10.1016/s0002-9440(10)62248-1 · 2005 · External reference
Structure, function, and pathology of Bruch’s membrane
2017 · External reference
Age-dependent variation in metalloproteinase activity of isolated human Bruch’s membrane and choroid
1999 · External reference
Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions
10.1074/jbc.274.16.10846 · 1999 · External reference
Macular dystrophies
2017 · External reference
Plasma levels of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) in age-related macular degeneration
10.1038/sj.eye.6702722x · 2008 · External reference
Cytokine concentration in aqueous humour of eyes with exudative age-related macular degeneration
10.1111/j.1755-3768.2012.02414.x · 2012 · External reference
MMP-2 and MMP-9 synergize in promoting choroidal neovascularization
10.1096/fj.03-0113fje · 2003 · External reference
NCBI’s Database of Genotypes and Phenotypes: dbGaP
10.1093/nar/gkt1211 · 2014 · External reference
Second-generation PLINK: rising to the challenge of larger and richer datasets
10.1186/s13742-015-0047-8 · 2015 · External reference
LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants
10.1093/bioinformatics/btv402 · 2015 · External reference
Combination therapy for neovascular age-related macular degeneration refractory to anti-vascular endothelial growth factor agents
10.1016/j.ophtha.2013.03.016 · 2013 · External reference
Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism
10.1080/13816810.2017.1369550 · 2018 · External reference
Analysis of myocilin mutations in 1703 glaucoma patients from five different populations
10.1093/hmg/8.5.899 · 1999 · External reference
The role of matrix metalloproteinases polymorphisms in age-related macular degeneration
10.3109/13816810.2013.838274 · 2015 · External reference
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
10.1016/s0092-8674(00)81169-1 · 1998 · External reference
Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm
10.1161/01.atv.14.8.1315 · 1994 · External reference
Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages
10.1172/jci118037 · 1995 · External reference
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapy
10.1093/brain/awg129 · 2003 · External reference
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
10.1016/s0092-8674(02)00754-7 · 2002 · External reference
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
10.1172/jci200422087 · 2004 · External reference
Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis
10.1073/pnas.0706438104 · 2007 · External reference
Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration
10.1073/pnas.1914143116 · 2019 · External reference
Disturbed matrix metalloproteinase activity of Bruch’s membrane in age-related macular degeneration
10.1167/iovs.10-6678 · 2011 · External reference
Elastin-mediated choroidal endothelial cell migration: possible role in age-related macular degeneration
10.1167/iovs.08-1984 · 2008 · External reference
Serum elastin-derived peptides in age-related macular degeneration
10.1167/iovs.04-1277 · 2005 · External reference
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby’s fundus dystrophy
10.1038/ng1294-352 · 1994 · External reference
Predicting deleterious amino acid substitutions
10.1101/gr.176601 · 2001 · External reference
A method and server for predicting damaging missense mutations
10.1038/nmeth0410-248 · 2010 · External reference
Amino acid substitution matrices from protein blocks
10.1073/pnas.89.22.10915 · 1992 · External reference
The Genotype-Tissue Expression (GTEx) project
10.1038/ng.2653 · 2013 · External reference
Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis
10.1161/01.cir.99.14.1788 · 1999 · External reference
Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration
10.1038/srep32548 · 2016 · External reference
CD40 mediates retinal inflammation and neurovascular degeneration
10.4049/jimmunol.181.12.8719 · 2008 · External reference
The relationship between intervention in the CD40 signal pathway and choroidal neovascularization
2014 · External reference
Identification of signaling pathways by which CD40 stimulates autophagy and antimicrobial activity against Toxoplasma gondii in macrophages
10.1128/iai.00101-16 · 2016 · External reference
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
10.1093/hmg/ddi353 · 2005 · External reference
Susceptibility genes for age-related maculopathy on chromosome 10q26
10.1086/444437 · 2005 · External reference
ARMS2 (LOC387715) variants in Japanese patients with exudative age-related macular degeneration and polypoidal choroidal vasculopathy
10.1016/j.ajo.2008.12.036 · 2009 · External reference
The ARMS2 A69S variant and bilateral advanced age-related macular degeneration
10.1097/iae.0b013e318240a540 · 2012 · External reference
Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration
10.1016/j.ajo.2009.07.002 · 2009 · External reference
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
10.1016/j.ajo.2010.08.015 · 2011 · External reference
Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2)
2011 · External reference
Differentiation of exudative age-related macular degeneration and polypoidal choroidal vasculopathy in the ARMS2/HTRA1 locus
10.1167/iovs.11-8135 · 2012 · External reference
Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch’s membrane via cleavage of extracellular matrix components
10.1371/journal.pone.0022959 · 2011 · External reference
ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations
10.1167/iovs.09-3850 · 2010 · External reference
The role of human HtrA1 in arthritic disease
10.1074/jbc.m500361200 · 2006 · External reference