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References from Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
10.1016/s2214-109x(13)70145-1 · 2014 · External reference
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
10.1038/ng.3448 · 2016 · External reference
Family-based exome sequencing identifies rare coding variants in age-related macular degeneration
10.1093/hmg/ddaa057 · 2020 · External reference
A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration
10.1038/s41598-020-58510-9 · 2020 · External reference
Developing therapies for age-related macular degeneration: the art and science of problem-solving. The 2018 Charles L. Schepens, MD, Lecture
10.1016/j.oret.2019.07.015 · 2019 · External reference
Age-related macular degeneration revisited—piecing the puzzle. The LXIX Edward Jackson Memorial Lecture
10.1016/j.ajo.2012.10.018 · 2013 · External reference
Metabolomic quantitative trait loci (mQTL) mapping implicates the ubiquitin proteasome system in cardiovascular disease pathogenesis
10.1371/journal.pgen.1005553 · 2015 · External reference
Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics
10.1186/s12864-019-5772-4 · 2019 · External reference
Identification of novel non-synonymous variants associated with type 2 diabetes-related metabolites in Korean population
10.1042/bsr20190078 · 2019 · External reference
Genetic variation in metabolic phenotypes: study designs and applications
10.1038/nrg3314 · 2012 · External reference
A multi-tissue transcriptome analysis of human metabolites guides interpretability of associations based on multi-SNP models for gene expression
10.1016/j.ajhg.2020.01.003 · 2020 · External reference
Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy
10.1371/journal.pone.0177749 · 2017 · External reference
Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers
10.1016/j.ophtha.2017.08.008 · 2018 · External reference
Human plasma metabolomics in age-related macular degeneration: meta-analysis of two cohorts
10.3390/metabo9070127 · 2019 · External reference
Integrating metabolomics, genomics and disease pathways in age-related macular degeneration: the EYE-RISK Consortium
10.1016/j.ophtha.2020.06.020 · 2020 · External reference
The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research
10.1007/978-1-4939-2377-9_13 · 2015 · External reference
Prevalence of age-related macular degeneration in Portugal: the Coimbra Eye Study—report 1
10.1159/000371584 · 2015 · External reference
Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 report number 2)
10.1167/iovs.13-11804 · 2013 · External reference
Automated brightness and contrast adjustment of color fundus photographs for the grading of age-related macular degeneration
10.1167/tvst.6.2.3 · 2017 · External reference
The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6
10.1016/s0002-9394(01)01218-1 · 2001 · External reference
Metabolomics in the study of retinal health and disease
10.1016/j.preteyeres.2018.11.002 · 2019 · External reference
Centering, scaling, and transformations: improving the biological information content of metabolomics data
10.1186/1471-2164-7-142 · 2006 · External reference
A prospective analysis of circulating plasma metabolites associated with ovarian cancer risk
10.1158/0008-5472.can-19-2567 · 2020 · External reference
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
10.1038/s41467-019-13770-6 · 2020 · External reference
On the combination of independent tests
1958 · External reference
Matrix eQTL: ultra fast eQTL analysis via large matrix operations
10.1093/bioinformatics/bts163 · 2012 · External reference
Identifying differentially expressed genes using false discovery rate controlling procedures
10.1093/bioinformatics/btf877 · 2003 · External reference
Seven new loci associated with age-related macular degeneration
10.1038/ng.2578 · 2013 · External reference
Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration
10.1038/s41598-019-43144-3 · 2019 · External reference
Genetic susceptibility, diet quality, and two-step progression in drusen size
10.1167/iovs.61.5.17 · 2020 · External reference
Coronary artery disease, genetic risk and the metabolome in young individuals
10.12688/wellcomeopenres.14788.2 · 2019 · External reference
MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis
10.1093/nar/gky310 · 2018 · External reference
Mendelian randomization implicates high-density lipoprotein cholesterol–associated mechanisms in etiology of age-related macular degeneration
10.1016/j.ophtha.2017.03.042 · 2017 · External reference
Pathway analysis integrating genome-wide and functional data identifies PLCG2 as a candidate gene for age-related macular degeneration
10.1167/iovs.19-27827 · 2019 · External reference
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
10.1371/journal.pgen.1000282 · 2008 · External reference
Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders
10.1016/s0009-3084(00)00128-6 · 2000 · External reference
Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint
10.1194/jlr.m070714 · 2017 · External reference
Lipids and lipid metabolism in the eye
10.1194/jlr.e003533 · 2010 · External reference
Mechanisms and treatment of light-induced retinal degeneration-associated inflammation: Insights from biochemical profiling of the aqueous humor
10.3390/ijms21030704 · 2020 · External reference
The association between the lipids levels in blood and risk of age-related macular degeneration
10.3390/nu8100663 · 2016 · External reference
Overexpression of ASPM, CDC20, and TTK confer a poorer prognosis in breast cancer identified by gene co-expression network analysis
10.3389/fonc.2019.00310 · 2019 · External reference
Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions
10.1016/j.phrs.2018.05.014 · 2018 · External reference
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci
10.1093/hmg/ddr581 · 2012 · External reference
Thematic review series. High density lipoprotein structure, function, and metabolism: unraveling the complexities of the HDL lipidome
10.1194/jlr.r036095 · 2013 · External reference
Nature and nurture—genes and environment—predict onset and progression of macular degeneration
10.1016/j.preteyeres.2013.12.004 · 2014 · External reference