Research graph
References from Rescue of the Congenital Hereditary Endothelial Dystrophy Mouse Model by Adeno-Associated Virus–Mediated Slc4a11 Replacement. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanisms underlying the corneal endothelial pump
10.1016/j.exer.2011.06.004 · 2012 · External reference
Biology of the corneal endothelium in health and disease
10.1038/sj.eye.6700559 · 2003 · External reference
Pediatric keratoplasty
10.1016/j.survophthal.2008.12.011 · 2009 · External reference
Mutations in sodium-borate cotransporter SLC4A11 cause recessive congenital hereditary endothelial dystrophy (CHED2)
10.1038/ng1824 · 2006 · External reference
Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy
10.1167/iovs.13-12089 · 2013 · External reference
Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress
10.1016/j.redox.2019.101260 · 2019 · External reference
SLC4A11 depletion impairs NRF2 mediated antioxidant signaling and increases reactive oxygen species in human corneal endothelial cells during oxidative stress
10.1038/s41598-017-03654-4 · 2017 · External reference
Genetics of the corneal endothelial dystrophies: an evidence-based review
10.1111/cge.12191 · 2013 · External reference
Inducible Slc4a11 knockout triggers corneal edema through perturbation of corneal endothelial pump
10.1167/iovs.62.7.28 · 2021 · External reference
Bicarbonate activates glycolysis and lactate production in corneal endothelial cells by increased pHi
10.1016/j.exer.2020.108193 · 2020 · External reference
Descemet-stripping automated endothelial keratoplasty for congenital hereditary endothelial dystrophy
10.1001/archophthalmol.2011.114 · 2011 · External reference
Corneal transplantation
10.1016/s0140-6736(12)60437-1 · 2012 · External reference
Shortage in the face of plenty: Improving the allocation of corneas for transplantation
2002 · External reference
Prospects and challenges of translational corneal bioprinting
10.3390/bioengineering7030071 · 2020 · External reference
Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells
10.1002/jgm.886 · 2006 · External reference
Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice
10.1002/jgm.1327 · 2009 · External reference
Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy
10.7554/elife.55637 · 2021 · External reference
Adeno-associated virus mediated gene therapy for corneal diseases
10.3390/pharmaceutics12080767 · 2020 · External reference
Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma
10.1093/hmg/ddx028 · 2017 · External reference
Corneal endothelial pump coupling to lactic acid efflux in the rabbit and mouse
10.1167/iovs.61.2.7 · 2020 · External reference
Fluid transport by the cornea endothelium is dependent on buffering lactic acid efflux
10.1152/ajpcell.00095.2016 · 2016 · External reference
CD147 required for corneal endothelial lactate transport
10.1167/iovs.14-14386 · 2014 · External reference
Lactate-H + transport is a significant component of the in vivo corneal endothelial pump
10.1167/iovs.12-9475 · 2012 · External reference
Corneal endothelial cell dysfunction: etiologies and management
2018 · External reference
Molecular bases of corneal endothelial dystrophies
2010 · External reference
SOD2 contributes to anti-oxidative capacity in rabbit corneal endothelial cells
2011 · External reference
The status of RPE65 gene therapy trials: safety and efficacy
10.1101/cshperspect.a017285 · 2015 · External reference
Advances in gene therapy for diseases of the eye
10.1089/hum.2016.040 · 2016 · External reference
Mitochondrial ROS induced lysosomal dysfunction and autophagy impairment in an animal model of congenital hereditary endothelial dystrophy
10.1167/iovs.62.12.15 · 2021 · External reference
SLC4A11 and the pathophysiology of congenital hereditary endothelial dystrophy
10.1155/2015/475392 · 2015 · External reference
Mutational spectrum of SLC4A11 in autosomal recessive CHED in Saudi Arabia
10.1167/iovs.08-3006 · 2009 · External reference
Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family
2020 · External reference
Identification of mutations in the SLC4A11 gene in patients with recessive congenital hereditary endothelial dystrophy
10.1001/archopht.126.5.700 · 2008 · External reference
Multifunctional ion transport properties of human SLC4A11: comparison of the SLC4A11-B and SLC4A11-C variants
10.1152/ajpcell.00233.2016 · 2016 · External reference
Human corneal expression of SLC4A11, a gene mutated in endothelial corneal dystrophies
10.1038/s41598-019-46094-y · 2019 · External reference
