Research graph
References from Phase 1 Clinical Trial of Elamipretide in Intermediate Age-Related Macular Degeneration and High-Risk Drusen. Local targets link to admitted publications; unresolved targets remain external evidence.
The prevalence of age-related eye diseases and visual impairment in aging: current estimates
10.1167/iovs.13-12789 · 2013 · External reference
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
10.1186/s40662-016-0063-5 · 2016 · External reference
Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity
10.1016/s0161-6420(97)30079-7 · 1997 · External reference
Cone- and rod-mediated dark adaptation impairment in age-related maculopathy
10.1016/j.ophtha.2006.12.023 · 2007 · External reference
Low luminance visual dysfunction as a predictor of subsequent visual acuity loss from geographic atrophy in age-related macular degeneration
10.1016/j.ophtha.2008.03.009 · 2008 · External reference
Longitudinal changes in microperimetry and low luminance visual acuity in age-related macular degeneration
10.1001/jamaophthalmol.2014.5963 · 2015 · External reference
Longitudinal study of visual function in dry age-related macular degeneration at 12 months
10.1016/j.oret.2019.03.010 · 2019 · External reference
Development of a questionnaire to assess vision problems under low luminance in age-related maculopathy
10.1167/iovs.05-1222 · 2006 · External reference
Natural history of geographic atrophy secondary to age-related macular degeneration: results from the prospective Proxima A and B clinical trials
10.1016/j.ophtha.2019.12.009 · 2020 · External reference
Characterizing disease burden and progression of geographic atrophy secondary to age-related macular degeneration
10.1016/j.ophtha.2017.11.036 · 2018 · External reference
Enrichment of macular pigment enhances contrast sensitivity in subjects free of retinal disease: Central Retinal Enrichment Supplementation Trials—report 1
10.1167/iovs.16-19520 · 2016 · External reference
Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR Study
10.1167/iovs.12-10715 · 2013 · External reference
The burden of age-related macular degeneration: A value-based medicine analysis.
2005 · External reference
Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study
10.1016/j.ophtha.2014.03.013 · 2014 · External reference
Prevalence of age-related macular degeneration in the US population
10.1001/archophthalmol.2010.318 · 2011 · External reference
Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study
10.1167/iovs.14-14246 · 2014 · External reference
Nitrate-nitrogen levels in rural drinking water: is there an association with age-related macular degeneration?
10.1080/10934529.2013.823323 · 2013 · External reference
Hypertension, cardiovascular disease, and age-related macular degeneration
10.1001/archopht.118.3.351 · 2000 · External reference
Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration
10.1167/iovs.10-5429 · 2010 · External reference
Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration
10.1167/iovs.07-1352 · 2008 · External reference
A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD
10.1016/j.exer.2009.01.017 · 2009 · External reference
The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation
10.1006/exer.2002.2047 · 2002 · External reference
Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD
10.1167/iovs.05-0719 · 2006 · External reference
Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT)
10.1016/j.ophtha.2012.11.037 · 2013 · External reference
Inflammation and cell death in age-related macular degeneration: an immunopathological and ultrastructural model
2014 · External reference
Fundus autofluorescence and the bisretinoids of retina
10.1039/c0pp00207k · 2010 · External reference
Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration
10.1016/j.preteyeres.2015.09.002 · 2016 · External reference
Mitochondria: potential targets for protection in age-related macular degeneration
2018 · External reference
Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration
10.1016/j.mam.2012.04.006 · 2012 · External reference
Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration
10.1016/j.exer.2016.01.018 · 2016 · External reference
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
10.1016/j.preteyeres.2020.100858 · 2020 · External reference
Investigating mitochondria as a target for treating age-related macular degeneration
10.1523/jneurosci.0190-15.2015 · 2015 · External reference
Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity
10.1167/iovs.04-1224 · 2005 · External reference
Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells
10.1016/j.freeradbiomed.2014.01.004 · 2014 · External reference
Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E
10.1167/iovs.03-0910 · 2004 · External reference
Unresolved reference
2016 · External reference
The role of mitochondria in AMD: current knowledge and future applications
10.4103/jovr.jovr_182_17 · 2017 · External reference
Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy
10.1016/j.ophtha.2012.10.007 · 2013 · External reference
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors
10.1073/pnas.1100957108 · 2011 · External reference
Fine astrocyte processes contain very small mitochondria: glial oxidative capability may fuel transmitter metabolism
10.1007/s11064-015-1563-8 · 2015 · External reference
Beyond polarity: functional membrane domains in astrocytes and Müller cells
10.1007/s11064-012-0824-z · 2012 · External reference
Mitochondrial reactive oxygen species production and elimination
10.1016/j.yjmcc.2014.03.011 · 2014 · External reference
Elamipretide protects RPE and improves mitochondrial function in models of AMD
2017 · External reference
Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis
10.1111/bph.12468 · 2014 · External reference
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
10.1111/bph.12461 · 2014 · External reference
Baseline MNREAD measures for normally sighted subjects from childhood to old age
10.1167/iovs.16-19580 · 2016 · External reference
Visual function measures in early and intermediate age-related macular degeneration
10.1097/iae.0000000000001002 · 2016 · External reference
Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration
10.1167/iovs.13-13745 · 2014 · External reference
Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography
10.1016/j.ophtha.2013.07.013 · 2014 · External reference
MultipleTesting.com: a tool for life science researchers for multiple hypothesis testing correction
10.1371/journal.pone.0245824 · 2021 · External reference
Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints
10.1016/j.ajo.2018.02.012 · 2018 · External reference
A mitochondrial therapeutic reverses visual decline in mouse models of diabetes
2015 · External reference
Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney
10.1152/ajprenal.00366.2014 · 2015 · External reference
Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis
10.1152/ajprenal.00697.2013 · 2014 · External reference
Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy
10.1212/wnl.0000000000005255 · 2018 · External reference
Effects of elamipretide on left ventricular function in patients with heart failure with reduced ejection fraction: the PROGRESS-HF phase 2 trial: effects of elamipretide in heart failure
10.1016/j.cardfail.2020.02.001 · 2020 · External reference
Novel mitochondria-targeting peptide in heart failure treatment
2017 · External reference
Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36
10.1001/jamaophthalmol.2013.6636 · 2014 · External reference