Research graph
References from Hydrostatic Compressive Stress Promotes MC3T3-E1 Cell Proliferation Through ROCK-Dependent Regulation of Cyclin D1 and CDK4. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanical regulation of bone remodeling
10.1038/s41413-022-00190-4 · 2022 · External reference
Response of Osteoblasts to the Stimulus of Fluid Flow
10.1615/critreveukaryotgeneexpr.2015013564 · 2015 · External reference
Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice
10.1002/jbmr.74 · 2010 · External reference
Influence of intramedullary pressure on Lacuno-Canalicular fluid flow: A systematic review
10.1016/j.actbio.2024.03.003 · 2024 · External reference
Optimal compressive force induces bone formation via increasing bone sialoprotein and prostaglandin E2 production appropriately
10.1016/j.lfs.2005.03.037 · 2005 · External reference
NF‐κB responds to mechanical strains in osteoblast‐like cells, and lighter strains create an NF‐κB response more readily
10.1016/j.cellbi.2007.04.005 · 2007 · External reference
TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2 / PGE2 in intervertebral discs
10.1002/jsp2.1149 · 2021 · External reference
Insight into the role of integrins and integrins-targeting biomaterials in bone regeneration
10.1080/03008207.2024.2396002 · 2024 · External reference
Piezo1 opposes age‐associated cortical bone loss
10.1111/acel.13846 · 2023 · External reference
Dkk-1–TNF-α crosstalk regulates MC3T3E1 pre-osteoblast proliferation and differentiation under mechanical stress through the ERK signaling pathway
10.1007/s11010-022-04645-4 · 2023 · External reference
β-Catenin: A Key Molecule in Osteoblast Differentiation
10.3390/biom15071043 · 2025 · External reference
Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology
10.1016/j.jot.2024.12.003 · 2025 · External reference
Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine
10.1016/j.actbio.2023.01.039 · 2023 · External reference
Regulating Rho GTPases and their regulators
10.1038/nrm.2016.67 · 2016 · External reference
Rho Kinases in Embryonic Development and Stem Cell Research
10.1007/s00005-022-00642-z · 2022 · External reference
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization
10.1016/j.bbagen.2017.02.005 · 2017 · External reference
Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho‐ROCK ‐mediated contractility dependent
10.1002/btm2.10509 · 2023 · External reference
RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis
10.1016/j.cellsig.2024.111300 · 2024 · External reference
Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling
10.1038/s42003-025-07946-8 · 2025 · External reference
Acute compressive stress activates RHO/ROCK-mediated cellular processes
10.1080/21541248.2017.1413496 · 2020 · External reference
0.5-Gy X-ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts
10.3892/mmr.2021.12018 · 2021 · External reference
Review: Bone tissue engineering: The role of interstitial fluid flow
10.1002/bit.260430706 · 1994 · External reference
Fluid shear force and hydrostatic pressure jointly promote osteogenic differentiation of BMSCs by activating YAP1 and NFAT2
10.1002/biot.202300714 · 2024 · External reference
Cyclic Compressive Stress Regulates Apoptosis in Rat Osteoblasts: Involvement of PI3K/Akt and JNK MAPK Signaling Pathways
10.1371/journal.pone.0165845 · 2016 · External reference
Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway
10.3892/mmr.2017.6327 · 2017 · External reference
Microdevice-based mechanical compression on living cells
10.1016/j.isci.2022.105518 · 2022 · External reference
YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development
10.1016/j.devcel.2023.11.029 · 2024 · External reference
Proliferation and Activation of Osterix‐Lineage Cells Contribute to Loading‐Induced Periosteal Bone Formation in Mice
10.1002/jbm4.10227 · 2019 · External reference
The Critical Role of Transcription Factor RUNX2 in Bone Mechanobiology
10.3390/cells15010050 · 2026 · External reference
Determining Which Hydrostatic Pressure Regimes Promote Osteogenesis in Human Mesenchymal Stem Cells
10.1007/s13770-024-00666-w · 2024 · External reference
