Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Adipose-derived stem cell exosomes alleviate oxidative damage and reduce intraocular pressure in primary open-angle glaucoma via the ROS-mediated PI3K/AKT pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Major review: Molecular genetics of primary open-angle glaucoma
10.1016/j.exer.2017.05.002 · 2017 · External reference
The role of oxidative stress in glaucoma
10.1016/j.mrrev.2005.11.001 · 2006 · External reference
10.1155/2019/1803619
10.1155/2019/1803619 · External reference
Glutamate-induced glutamine synthetase expression in retinal Muller cells after short-term ocular hypertension in the rat
10.1167/iovs.03-0948 · 2004 · External reference
Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma
10.1136/bjo.2003.028357 · 2004 · External reference
Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes
10.1186/s12933-016-0369-6 · 2016 · External reference
Mesenchymal stem cell and derived exosome as small RNA carrier and Immunomodulator to improve islet transplantation
10.1016/j.jconrel.2016.07.044 · 2016 · External reference
Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma
1996 · External reference
Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma
10.1371/journal.pone.0014567 · 2011 · External reference
Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: The trabecular meshwork
10.1002/(sici)1097-4652(199908)180:2<182::aid-jcp6>3.0.co;2-x · 1999 · External reference
Oxidative stress in the trabecular meshwork of POAG, Klin
2010 · External reference
Free radicals in the physiological control of cell function
10.1152/physrev.00018.2001 · 2002 · External reference
The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice
10.1016/j.intimp.2015.01.011 · 2015 · External reference
Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced acute lung injury by suppressing PI3K/AKT/mTOR signaling pathway
10.1016/j.jep.2015.03.068 · 2015 · External reference
Redox regulation of protein kinases
10.1111/febs.12224 · 2013 · External reference
Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/AKT-dependant manner
10.1016/j.stem.2010.11.028 · 2010 · External reference
Communication by extracellular vesicles: Where we are and where we need to go
10.1016/j.cell.2016.01.043 · 2016 · External reference
Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia
10.1016/j.biopha.2018.06.032 · 2018 · External reference
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
10.1002/ijc.30179 · 2016 · External reference
Therapeutic potential of mesenchymal stem cells and their secretome in the treatment of glaucoma
10.1155/2019/7869130 · 2019 · External reference
Exosomes are released by cultured cortical neurones
10.1016/j.mcn.2005.12.003 · 2006 · External reference
Induction of inflammatory responses in splenocytes by exosomes released from intestinal epithelial cells following Cryptosporidium parvum infection
10.1128/iai.00705-18 · 2019 · External reference
Protein profile of exosomes from trabecular meshwork cells
10.1016/j.jprot.2011.02.024 · 2011 · External reference
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
10.1038/ncomms8321 · 2015 · External reference
Body fluid derived exosomes as a novel template for clinical diagnostics
10.1186/1479-5876-9-86 · 2011 · External reference
Exosomal-like vesicles are present in human blood plasma
10.1093/intimm/dxh267 · 2005 · External reference
Exosomes with immune modulatory features are present in human breast milk
10.4049/jimmunol.179.3.1969 · 2007 · External reference
Exosomes from human saliva as a source of microRNA biomarkers
10.1111/j.1601-0825.2009.01604.x · 2010 · External reference
Current state of the art for enhancing urine biomarker discovery
10.1080/14789450.2016.1190651 · 2016 · External reference
Roles of exosomes in the normal and diseased eye
10.1016/j.preteyeres.2017.04.004 · 2017 · External reference
Progress in exosomes and their potential use in ocular diseases
10.18240/ijo.2020.09.23 · 2020 · External reference
Extracellular vesicles mediate anti-oxidative response-in vitro study in the ocular drainage system
10.3390/ijms21176105 · 2020 · External reference
Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms
10.1002/sctm.16-0428 · 2017 · External reference
Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model
2018 · External reference
Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy
10.1038/s41598-018-25515-4 · 2018 · External reference
Adipose mesenchymal stromal cell-derived exosomes prevent testicular torsion injury via activating PI3K/AKT and MAPK/ERK1/2 pathways
2022 · External reference
Exosomes communicate protective messages during oxidative stress; Possible role of exosomal shuttle RNA
10.1371/journal.pone.0015353 · 2010 · External reference
Oxidative stress and mitochondrial dysfunction in glaucoma
10.1016/j.coph.2012.09.008 · 2013 · External reference
Glaucoma: Recent advances in the involvement of autoimmunity
10.1007/s12026-016-8837-3 · 2017 · External reference
Glutathione in calf trabecular meshwork and its relation to aqueous humor outflow facility
1983 · External reference
Characterization of TGF-β by induced oxidative stress in human trabecular meshwork cells
10.3390/antiox10010107 · 2021 · External reference
Salidroside mitigates hydrogen peroxide-induced injury by enhancement of microRNA-27a in human trabecular meshwork cells
10.1080/21691401.2019.1608222 · 2019 · External reference
Mitochondria-targeted peptide MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells
10.1167/iovs.11-7524 · 2011 · External reference
Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues
10.1167/iovs.07-0984 · 2008 · External reference
Extracellular vesicle-mediated crosstalk between NPCE cells and TM cells result in modulation of Wnt signalling pathway and ECM remodelling
10.1111/jcmm.15129 · 2020 · External reference
Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro
10.1186/scrt194 · 2013 · External reference
Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of oncotarget
10.18632/oncotarget.9852 · 2016 · External reference
Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/AKT signaling pathway
10.1016/j.yexcr.2018.06.035 · 2018 · External reference
Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury
10.1016/j.bbrc.2018.04.065 · 2018 · External reference
Exosomes from adipose-derived mesenchymal stem cells prevent cardiomyocyte apoptosis induced by oxidative stress
10.1038/s41420-019-0159-5 · 2019 · External reference
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/AKT pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
10.1016/j.scr.2013.01.002 · 2013 · External reference
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
10.1146/annurev-cellbio-101512-122326 · 2014 · External reference
Directional cell movement through tissues is controlled by exosome secretion
10.1038/ncomms8164 · 2015 · External reference
Specialized podosome- or invadopodia-like structures (PILS) for focal trabecular meshwork extracellular matrix turnover
10.1167/iovs.07-1666 · 2008 · External reference
Functional delivery of viral miRNAs via exosomes
10.1073/pnas.0914843107 · 2010 · External reference
Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats
2002 · External reference
Animal models of glucocorticoid-induced glaucoma
10.1016/j.exer.2015.06.002 · 2015 · External reference
Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes
10.3109/02713683.2010.494240 · 2010 · External reference
Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure
10.1016/j.exer.2015.05.012 · 2015 · External reference
The microbead occlusion model: A paradigm for induced ocular hypertension in rats and mice
10.1167/iovs.09-3947 · 2010 · External reference
Localization of myocilin/trabecular meshwork-inducible glucocorticoidresponse protein in the human eye
2000 · External reference
Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: Implication for glaucoma pathogenesis
10.2353/ajpath.2010.090853 · 2010 · External reference
Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells
2009 · External reference
iPSC-derived trabecular meshwork cells stimulate endogenous TM cell division through gap junction in a mouse model of glaucoma
10.1167/iovs.62.10.28 · 2021 · External reference
Intraocular pressure reduction and neuroprotection conferred by bone marrow-derived mesenchymal stem cells in an animal model of glaucoma
10.1186/s13287-015-0168-0 · 2015 · External reference
Adipose-derived stem cells integrate into trabecular meshwork with glaucoma treatment potential
10.1096/fj.201902326r · 2020 · External reference
Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC
10.1186/1478-811x-9-12 · 2011 · External reference
Highly-expressed microRNA-21 in adipose derived stem cell exosomes can enhance the migration and proliferation of the HaCaT cells by increasing the MMP-9 expression through the PI3K/AKT pathway
10.1016/j.abb.2020.108259 · 2020 · External reference
Non-coding RNAs in adipose-derived stem cell exosomes: mechanisms, therapeutic potential, and challenges in wound healing
10.4252/wjsc.v17.i4.102917 · 2025 · External reference
Adipose-derived stem cell exosomes facilitate diabetic wound healing: mechanisms and potential applications
10.2147/ijn.s466034 · 2024 · External reference
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis
10.7150/thno.96038 · 2024 · External reference
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
10.1172/jci58183 · 2011 · External reference
Expression of mutant myocilin induces abnormal intracellular accumulation of selected extracellular matrix proteins in the trabecular meshwork
10.1167/iovs.16-19610 · 2016 · External reference
Myocilin-associated glaucoma: a historical perspective and recent research progress
2021 · External reference