Research graph
References from Elevated asymmetric dimethylarginine drives hematopoietic stem cell metabolic reprogramming and dysfunction in chronic kidney disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Chronic kidney disease
10.1016/s0140-6736(21)00519-5 · 2021 · External reference
Chronic kidney disease and risk of death from infection
10.1159/000330673 · 2011 · External reference
Endothelial damage, inflammation and immunity in chronic kidney disease
10.3390/toxins12060361 · 2020 · External reference
Chronic kidney disease-associated immune dysfunctions: impact of protein-bound uremic retention solutes on immune cells
10.3390/toxins12050300 · 2020 · External reference
Reprograms hematopoietic stem cells to limit myelopoiesis and impair trained immunity
10.1016/j.cell.2020.09.062 · 2020 · External reference
Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
10.1016/j.celrep.2022.110392 · 2022 · External reference
Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate
10.1084/jem.20131189 · 2014 · External reference
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease–associated thrombosis in mice
10.1182/blood-2016-10-744060 · 2017 · External reference
Noncardiovascular mortality in CKD: an epidemiological perspective
10.1038/nrneph.2014.8 · 2014 · External reference
Hematopoietic stem cell metabolism during development and aging
10.1016/j.devcel.2020.06.029 · 2020 · External reference
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
10.1038/s41581-020-00345-8 · 2021 · External reference
Metabolomics for clinical use and research in chronic kidney disease
10.1038/nrneph.2017.30 · 2017 · External reference
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk
10.1016/j.phrs.2009.07.001 · 2009 · External reference
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys
10.1096/fj.201802585rr · 2019 · External reference
Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines in chronic kidney disease: a clinical approach
2019 · External reference
Vascular and immunopathological role of asymmetric dimethylarginine (ADMA) in experimental autoimmune encephalomyelitis
10.1111/imm.13396 · 2021 · External reference
Mitochondrial damage-induced innate immune activation in vascular smooth muscle cells promotes chronic kidney disease-associated plaque vulnerability
2021 · External reference
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF‐β1 synthesis
10.1002/path.2769 · 2011 · External reference
Association of serum polyamines with cardiovascular events and all-cause mortality in chronic kidney disease
10.1159/000545054 · 2025 · External reference
Prognostic value of a novel myeloid-to-lymphoid ratio biomarker in advanced gastric cancer
10.1007/s12094-024-03612-3 · 2025 · External reference
Elevated levels of Ube2g1 in hematopoietic stem cells lead to segmental aging of the hematopoietic system
2020 · External reference
On behalf of the retard cohort team, peripheral blood myeloid-to-lymphoid ratio: a novel indicator for assessing renal and cardiovascular risks in chronic kidney disease patients—a multicenter longitudinal investigation
10.1186/s40001-025-03668-z · 2025 · External reference
SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice
10.1182/blood-2018-02-831669 · 2018 · External reference
Srebf1c preserves hematopoietic stem cell function and survival as a switch of mitochondrial metabolism
10.1016/j.stemcr.2022.01.011 · 2022 · External reference
An innovative, time‐ and cost‐saving method for the quantification of asymmetric dimethylarginine in serum by high‐performance liquid chromatography without evaporation
10.1002/sscp.202000082 · 2020 · External reference
STEM CELL AGING. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
10.1126/science.aaa2361 · 2015 · External reference
Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis
10.1186/s12964-024-01959-2 · 2024 · External reference
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
10.1016/j.stem.2011.09.010 · 2011 · External reference
TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis
10.1182/blood.2020007489 · 2021 · External reference
IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice
10.1182/blood-2014-06-583187 · 2015 · External reference
The Dlk1-Gtl2 locus preserves LT-HSC function by inhibiting the PI3K-mTOR pathway to restrict mitochondrial metabolism
10.1016/j.stem.2015.11.001 · 2016 · External reference
ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity
10.1182/blood.2020007975 · 2020 · External reference
Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis
2023 · External reference
Unresolved reference
External reference
Phosphatase PP2A is requisite for the function of regulatory T cells
10.1038/ni.3390 · 2016 · External reference
Asymmetric dimethylarginine and whole blood viscosity in renal failure
10.3233/ch-141843 · 2015 · External reference
Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance
10.1126/science.aap8861 · 2018 · External reference
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy
10.1038/nature12932 · 2014 · External reference
Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis
10.1016/j.ajpath.2013.11.016 · 2014 · External reference
Nitric oxide is a regulator of hematopoietic stem cell activity
10.1016/j.ymthe.2004.05.030 · 2004 · External reference
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
10.1016/j.stem.2022.06.012 · 2022 · External reference
Always stressed but never exhausted: how stem cells in myeloid neoplasms avoid extinction in inflammatory conditions
2023 · External reference
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
10.1038/ncb3346 · 2016 · External reference
Aging of hematopoietic stem cells
10.1182/blood-2017-06-746412 · 2018 · External reference
Aging alters the cell cycle control and mitogenic signaling responses of human hematopoietic stem cells
10.1182/blood.2022017174 · 2023 · External reference
Hallmarks of stem cell aging
2025 · External reference
An inflammatory and quiescent HSC subpopulation expands with age in humans
2026 · External reference
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
10.1016/j.stem.2012.10.011 · 2013 · External reference
Vitamin A-Retinoic acid signaling regulates hematopoietic stem cell dormancy
10.1016/j.cell.2017.04.018 · 2017 · External reference
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
10.1038/nm.2882 · 2012 · External reference
Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury
10.1016/j.stem.2024.07.009 · 2024 · External reference
Metabolic regulation of hematopoietic stem cells
10.1097/hs9.0000000000000740 · 2022 · External reference
mTOR signaling in growth, metabolism, and disease
10.1016/j.cell.2017.03.035 · 2017 · External reference
mTOR signaling as a regulator of hematopoietic stem cell fate
10.1007/s12015-021-10131-z · 2021 · External reference
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
10.1016/j.cmet.2013.10.001 · 2013 · External reference
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
10.1038/nature06322 · 2007 · External reference
mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis
10.1016/j.stem.2012.06.009 · 2012 · External reference
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
10.1038/ncb1183 · 2004 · External reference
Ca2+-mitochondria axis drives cell division in hematopoietic stem cells
10.1084/jem.20180421 · 2018 · External reference
HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
2023 · External reference
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer
10.1016/j.ccr.2010.10.021 · 2010 · External reference
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the chronic renal insufficiency cohort (CRIC) study
10.1093/ndt/gfad103 · 2023 · External reference
