Research graph
References from The role of renin-angiotensin system modulation in the pathophysiology of neuropsychiatric disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2017 · External reference
Therapeutic implications of renin–angiotensin system modulators in Alzheimer’s dementia
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Unresolved reference
External reference
Electroacupuncture inhibits oxidative stress and improves cognitive function by downregulating the Ang II/AT1R/NOX axis in chronic cerebral ischemia rats
10.1016/j.neulet.2025.138179 · 2025 · External reference
Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase*
10.1074/jbc.c100512200 · 2001 · External reference
ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models
10.1007/s11064-018-2679-4 · 2019 · External reference
Role of brain renin–angiotensin system in depression: a new perspective
10.1111/cns.14525 · 2024 · External reference
Anxiolytic- and antidepressant-like effects of angiotensin-(1–7) in hypertensive transgenic (mRen2)27 rats
10.1042/cs20160116 · 2016 · External reference
Identification of an angiotensin-(1–7)-producing fusion protein in the brain of transgenic rats reveals a hypotensive effect mediated through modulation of the GABA–nNOS–NO pathway and highlighting astrocyte–neuron crosstalk
10.1016/j.neuroscience.2026.01.025 · 2026 · External reference
Discovery of Inhibitors of Insulin-Regulated Aminopeptidase as Cognitive Enhancers
10.1155/2012/789671 · 2012 · External reference
Anti-stress and nootropic activity of drugs affecting the renin-angiotensin system in rats based on indirect biochemical evidence
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Angiotensin-(1–7) as a Potential Therapeutic Strategy for Delayed Cerebral Ischemia in Subarachnoid Hemorrhage
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Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury
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Peripheral administration of an angiotensin II AT1 receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation stress
10.1210/endo.142.9.8366 · 2001 · External reference
Stress weakens prefrontal networks: molecular insults to higher cognition
10.1038/nn.4087 · 2015 · External reference
The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment
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Role of AT1 receptors in permeability of the blood–brain barrier in diabetic hypertensive rats
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Protective effect of Irbesartan an Angiotensin (AT1) receptor antagonist in unpredictable chronic mild stress induced depression in mice
2017 · External reference
Comparative Study on the Neuroprotective Effects of Perindopril and Benazepril in Experimentally-induced Chronic Mild Stress in Rats
10.1007/s11481-025-10244-z · 2025 · External reference
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10.1515/revneuro-2015-0041 · 2016 · External reference
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Neuritogenesis and protective effects activated by Angiotensin 1–7 in astrocytes-neuron interaction
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The renin angiotensin system and bipolar disorder: a systematic review
10.2174/0929866527666200127115059 · 2020 · External reference
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The role of the ACE2/MasR axis in ischemic stroke: new insights for therapy
10.3390/biomedicines9111667 · 2021 · External reference
Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation
10.1038/npp.2010.225 · 2011 · External reference
Cutaneous inflammation differentially regulates the expression and function of Angiotensin-II types 1 and 2 receptors in rat primary sensory neurons
10.1111/jnc.14848 · 2020 · External reference
Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke
10.1007/s11906-014-0512-2 · 2015 · External reference
Angiotensin Receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/β-Catenin Signaling in Hypertension
10.1007/s12035-017-0754-5 · 2018 · External reference
AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47phox Phosphorylation by PP2A
10.1007/s12035-018-1272-9 · 2019 · External reference
The Protective Effects of AT2R Agonist, CGP42112A, Against Angiotensin II-Induced Oxidative Stress and Inflammatory Response in Astrocytes: Role of AT2R/PP2A/NFκB/ROS Signaling
10.1007/s12640-021-00403-4 · 2021 · External reference
Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus
10.1152/ajpheart.00247.2015 · 2016 · External reference
Angiotensin-(1–7) central administration induces anxiolytic-like effects in elevated plus maze and decreased oxidative stress in the amygdala
10.1016/j.jad.2012.07.024 · 2013 · External reference
Angiotensin II induces oxidative stress and endothelial dysfunction in mouse ophthalmic arteries via involvement of AT1 receptors and NOX2
10.3390/antiox10081238 · 2021 · External reference
Antihypertensive therapy in patients on chronic lithium treatment for bipolar disorders
10.1097/hjh.0000000000000758 · 2016 · External reference
10.1155/2013/102602
10.1155/2013/102602 · External reference
BDNF effects on dendritic spine morphology and hippocampal function
10.1007/s00441-017-2782-x · 2018 · External reference
Anterioposterior distribution of AT1 angiotensin receptors in caudal brainstem cardiovascular regulatory centers of the rat
10.1016/j.brainres.2009.09.116 · 2010 · External reference
Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension
10.1590/s0100-879x2011007500088 · 2011 · External reference
The AT-1 angiotensin receptor is involved in the autonomic and neuroendocrine responses to acute restraint stress in male rats
10.1007/s10571-021-01090-7 · 2021 · External reference
Candesartan prevents impairment of recall caused by repeated stress in rats
10.1007/s00213-012-2829-3 · 2013 · External reference
Ability of angiotensin II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo
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Angiotensin-converting enzyme (ACE) interacts with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice
10.1016/j.neulet.2005.01.009 · 2005 · External reference
Relationship between COVID-19 pandemic confinement and worsening or onset of depressive disorders
10.3390/brainsci13060899 · 2023 · External reference
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson’s diseases in vivo model
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Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation
10.1038/cdd.2013.108 · 2013 · External reference
Glutamate induced neonatal excitotoxicity modifies the expression level of EAAT1 (GLAST) and EAAT2 (GLT-1) proteins in various brain regions of the adult rat
10.1016/j.neulet.2020.135237 · 2020 · External reference
Exercise normalized the hippocampal renin-angiotensin system and restored spatial memory function, neurogenesis, and blood-brain barrier permeability in the 2K1C-hypertensive mouse
2022 · External reference
ACE2/Ang(1–7)/MasR axis exerts protective effects on lung ischemia/reperfusion injury via NF-κB-dependent mitochondrial adaptation and epithelial cell pyroptosis
10.1016/j.intimp.2025.115325 · 2025 · External reference
A case report of a bipolar disorder patient with severe lithium poisoning possibly induced by interaction between risperidone, telmisartan, fluvoxamine and lithium
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The effect of angiotensin AT1A inactivation on innate and learned fear responses in mice and its relationship to blood pressure
10.1016/j.psyneuen.2019.05.004 · 2019 · External reference
Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat
2011 · External reference
Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats
10.1016/j.jchemneu.2021.102061 · 2022 · External reference
The AT1/AT2 receptor equilibrium is a cornerstone of the regulation of the renin angiotensin system beyond the cardiovascular system
10.3390/molecules28145481 · 2023 · External reference
Involvement of the renin-angiotensin system in stress: state of the art and research perspectives
10.2174/1570159x19666210719142300 · 2022 · External reference
Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways
10.3390/ijms23158493 · 2022 · External reference
Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances
10.3390/ijtm4010010 · 2024 · External reference
Brain renin–angiotensin system at the intersect of physical and cognitive frailty
10.3389/fnins.2020.586314 · 2020 · External reference
Paracrine and Intracrine Angiotensin 1-7/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans
10.1007/s12035-017-0805-y · 2018 · External reference
Effects of captopril and SQ29,852 on anxiety-related behaviours in rodent and marmoset
10.1016/0091-3057(90)90118-2 · 1990 · External reference
Novel drug treatments for schizophrenia
2026 · External reference
Physiopathology of the brain renin-angiotensin system
10.3390/life15081333 · 2025 · External reference
Depression and anxiety during COVID-19
10.1016/s0140-6736(22)00187-8 · 2022 · External reference
Activation of angiotensin-converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling
10.1111/acel.13480 · 2021 · External reference
Angiotensin converting enzyme (ACE) gene expression in the human left ventricle: effect of ACE gene insertion/deletion polymorphism and left ventricular function
10.1016/s1388-9842(00)00070-2 · 2000 · External reference
Endothelial cells and macrophages as allies in the healthy and diseased brain
10.1007/s00401-024-02695-0 · 2024 · External reference
The influence of pharmacological mineralocorticoid and glucocorticoid receptor blockade on the cortisol response to psychological stress
10.1016/j.pnpbp.2023.110905 · 2024 · External reference
Unresolved reference
2026 · External reference
Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway
10.3389/fphys.2020.566410 · 2020 · External reference
Angiotensin Peptides As Neurotransmitters/ Neuromodulators In The Dorsomedial Medulla
10.1046/j.1440-1681.2002.03659.x · 2002 · External reference
Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson’s disease treated with l-DOPA
2014 · External reference
Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer’s disease
10.1096/fj.11-182873 · 2011 · External reference
GABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses
10.1038/s41440-020-0470-9 · 2020 · External reference
Telmisartan mitigates behavioral and cytokine level alterations but impairs spatial working memory in a phencyclidine-induced mouse model of schizophrenia
10.1007/s00213-025-06805-y · 2025 · External reference
Neuroprotective effects of candesartan in 3-nitropropionic acid-induced Huntington’s disease: modulation of angiotensin and CREB/BDNF/PGC1-α signaling
10.1007/s10787-025-01889-6 · 2025 · External reference
The effect of adjunctive telmisartan treatment on psychopathology and cognition in patients with schizophrenia
10.1111/acps.12799 · 2017 · External reference
Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4
10.1093/mutage/ges033 · 2012 · External reference
Electroacupuncture improved chronic cerebral hypoperfusion-induced anxiety-like behavior and memory impairments in spontaneously hypertensive rats by downregulating the ACE/Ang II/AT1R axis and upregulating the ACE2/Ang-(1-7)/MasR axis
10.1155/2020/9076042 · 2020 · External reference
10.2174/0118715273375375251114045754
10.2174/0118715273375375251114045754 · External reference
The role of aminopeptidases in angiotensin peptide processing
2026 · External reference
Biological actions of alamandine: a scoping review
10.3390/biomedicines13081957 · 2025 · External reference
Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C
10.1161/hypertensionaha.109.129353 · 2009 · External reference
Aldosterone and mineralocorticoid receptors: orphan questions
10.1046/j.1523-1755.2000.00975.x · 2000 · External reference
Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia
10.1038/tp.2015.181 · 2015 · External reference
10.64898/2025.12.24.696453
10.64898/2025.12.24.696453 · External reference
Activation of Central Angiotensin Type 2 Receptors Suppresses Norepinephrine Excretion and Blood Pressure in Conscious Rats
10.1038/ajh.2011.33 · 2011 · External reference
Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra
10.1007/s00429-012-0402-9 · 2013 · External reference
Biochemical and Neuropharmacology of Psychiatric Disorders
2024 · External reference
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
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Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-κB-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats
10.1007/s12035-017-0450-5 · 2018 · External reference
Angiotensin receptor blockers for bipolar disorder
10.1016/j.mehy.2012.11.043 · 2013 · External reference
Interaction of Endothelial and Neuronal Nitric-oxide Synthases with the Bradykinin B2 Receptor: BINDING OF AN INHIBITORY PEPTIDE TO THE OXYGENASE DOMAIN BLOCKS UNCOUPLED NADPH OXIDATION*
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Alamandine Induces Neuroprotection in Ischemic Stroke Models
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Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety
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Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders
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Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization
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How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?
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ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice
10.1016/j.intimp.2022.108944 · 2022 · External reference
NF-κB and CREB Are Required for Angiotensin II Type 1 Receptor Upregulation in Neurons
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Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
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Potentiation of NMDA receptors by AT1 angiotensin receptor activation in layer V pyramidal neurons of the rat prefrontal cortex
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Angiotensin-converting enzyme (ACE) inhibitors exacerbate histological damage and motor deficits after experimental traumatic brain injury
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Microglia-neuron interactions in schizophrenia
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Ang II-mediated effects on BBB integrity in psychiatric and neurological disorders
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Angiotensin-(1–7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas
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Compound 21, a Direct AT2R Agonist, Induces IL-10 and Inhibits Inflammation in Mice Following Traumatic Brain Injury
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Within the brain: the renin angiotensin system
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Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
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Upregulation of AT1 Receptor Mediates a Pressor Effect Through ROS-SAPK/JNK Signaling in Glutamatergic Neurons of Rostral Ventrolateral Medulla in Rats With Stress-Induced Hypertension
10.3389/fphys.2018.01860 · 2019 · External reference
Irbesartan attenuates TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-κB pathway in HUVECs
2015 · External reference
Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen
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Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1–7): Role of the Mas receptor
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Angiotensin mediated oxidative stress and neuroprotective potential of antioxidants and AT1 receptor blockers
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Brain angiotensin and dopaminergic degeneration: relevance to Parkinson’s disease
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Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors
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AT1 Receptor Mediated Hypertensive Response to Ang II in the Nucleus Tractus Solitarii of Normotensive Rats Involves NO Dependent Local GABA Release
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Chronic stress-associated depressive disorders: the impact of HPA axis dysregulation and neuroinflammation on the hippocampus—a mini review
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Angiotensin II Attenuates Synaptic GABA Release and Excites Paraventricular-Rostral Ventrolateral Medulla Output Neurons
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Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism
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Angiotensin-(1-7) protective effects in neurocognitive disorders: molecular mechanisms to therapeutic implications
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Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mammalian target of rapamycin complex 1
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Endogenous AT1 receptor–protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension
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New and old roles of the peripheral and brain renin–angiotensin–aldosterone system (RAAS): Focus on cardiovascular and neurological diseases
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Exploring the Evidence Implicating the Renin-Angiotensin System (RAS) in the Physiopathology of Mood Disorders
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TLR4 and AT1R mediate blood-brain barrier disruption, neuroinflammation, and autonomic dysfunction in spontaneously hypertensive rats
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Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and cognition impairment in patients with schizophrenia
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Schizophrenia-like endurable behavioral and neuroadaptive changes induced by ketamine administration involve Angiotensin II AT1 receptor
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Astrocytes and the Renin Angiotensin System: Relevance in Disease Pathogenesis
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Captopril prevents depressive-like behavior in an animal model of depression by enhancing hippocampal neurogenesis via activation of the ACE2/Ang (1–7)/Mas receptor/AMPK/BDNF pathway
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