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References from Multilevel metabolic engineering of Shewanella oneidensis as a heme-tolerant host for efficient porphyrin production. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolic engineering of E. coli for pyocyanin production
10.1016/j.ymben.2021.01.002 · 2021 · External reference
A simplified synthesis for meso-tetraphenylporphine
10.1021/jo01288a053 · 1967 · External reference
High-Level Bio-Based Production of Coproporphyrin in Escherichia coli
10.3390/fermentation10050250 · 2024 · External reference
An overview on AIEgen-decorated porphyrins: Current status and applications
10.1002/agt2.330 · 2023 · External reference
Regulation and Maturation of the Shewanella oneidensis Sulfite Reductase SirA
10.1038/s41598-020-57587-6 · 2020 · External reference
A Synthetic Plasmid Toolkit for Shewanella oneidensis MR-1
10.3389/fmicb.2019.00410 · 2019 · External reference
Temperature-induced metabolic reconfiguration and community shifts reveal the mechanistic basis of cold inhibition on anammox consortia
10.1007/s11783-026-2211-z · 2026 · External reference
Genome-scale metabolic network models: from first-generation to next-generation
10.1007/s00253-022-12066-y · 2022 · External reference
Superior performance of natural electron shuttles over a synthetic analogue in promoting electrogenic hydrocarbon degradation in contaminated soil
10.1007/s11783-026-2245-2 · 2026 · External reference
High-yield porphyrin production through metabolic engineering and biocatalysis
10.1038/s41587-024-02267-3 · 2025 · External reference
Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut
10.1038/s41564-024-01775-x · 2024 · External reference
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product
10.1128/mmbr.00048-16 · 2017 · External reference
Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax : new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes
10.1186/1471-2164-8-301 · 2007 · External reference
Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid
10.1002/bit.25886 · 2016 · External reference
Towards environmental systems biology of Shewanella
10.1038/nrmicro1947 · 2008 · External reference
Shewanella oneidensis cytochrome c maturation component CcmI is essential for heme attachment at the non-canonical motif of nitrite reductase NrfA
10.1111/mmi.12865 · 2014 · External reference
Dissociation between Iron and Heme Biosyntheses Is Largely Accountable for Respiration Defects of Shewanella oneidensis fur Mutants
10.1128/aem.00039-18 · 2018 · External reference
Electron Transfer Beyond the Outer Membrane: Putting Electrons to Rest
10.1146/annurev-micro-032221-023725 · 2023 · External reference
Multidimensional engineering of Saccharomyces cerevisiae for the efficient production of heme by exploring the cytotoxicity and tolerance of heme
10.1016/j.ymben.2024.07.007 · 2024 · External reference
Synergistic increase in coproporphyrin III biosynthesis by mitochondrial compartmentalization in engineered Saccharomyces cerevisiae
10.1016/j.synbio.2024.07.001 · 2024 · External reference
Merging automation and fundamental discovery into the design–build–test–learn cycle of nontraditional microbes
10.1016/j.tibtech.2022.03.004 · 2022 · External reference
Comprehensive detection of genes causing a phenotype using phenotype sequencing and pathway analysis
10.1371/journal.pone.0088072 · 2014 · External reference
Sub-cloning of the Wild-type proAB Region of the Escherichia coli Genome
10.1099/00221287-129-10-3215 · 1983 · External reference
Synthesis and Functionalization of Porphyrins through Organometallic Methodologies
10.1021/acs.chemrev.6b00427 · 2017 · External reference
A universal and wide-range cytosine base editor via domain-inlaid and fidelity-optimized CRISPR-FrCas9
10.1038/s41467-025-56655-7 · 2025 · External reference
Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumanniivia Dysregulation of Heme Biosynthesis
10.1021/acscentsci.0c01621 · 2021 · External reference
Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics
10.1016/j.pharmthera.2023.108487 · 2023 · External reference
Genome-scale modeling drives 70-fold improvement of intracellular heme production in Saccharomyces cerevisiae
2022 · External reference
FocA and its central role in fine-tuning pH homeostasis of enterobacterial formate metabolism
10.1099/mic.0.001253 · 2022 · External reference
Comparisons of Shewanella strains based on genome annotations, modeling, and experiments
10.1186/1752-0509-8-31 · 2014 · External reference
Biosynthesis of organic photosensitizer Znporphyrin by diphtheria toxin repressor DtxRmediated global upregulation of engineered heme biosynthesis pathway in Corynebacterium glutamicum
10.1038/s41598-018-32854-9 · 2018 · External reference
Animal-free heme production for artificial meat in Corynebacterium glutamicum via systems metabolic and membrane engineering
10.1016/j.ymben.2021.04.013 · 2021 · External reference
Coproduction of Bioelectricity and Acetoin by Unbalanced Fermentation of Glycerol in Shewanella oneidensis Based on a Genome-Scale Metabolic Network
10.1021/acssuschemeng.3c01724 · 2023 · External reference
Rediverting Electron Flux with an Engineered CRISPR-ddAsCpf1 System to Enhance the Pollutant Degradation Capacity of Shewanella oneidensis
10.1021/acs.est.9b06378 · 2020 · External reference
Improvement of isoprene production in Escherichia coli by rational optimization of RBSs and key enzymes screening
10.1186/s12934-018-1051-3 · 2019 · External reference
Notes on the synthesis of meso-substituted porphyrins from pyrryl carbinols and the mechanism of the rothemund reaction
10.1002/jhet.5570180444 · 1981 · External reference
Efficient biosynthesis of retinal from Escherichia coli by metabolic engineering
2025 · External reference
CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an l-proline exporter for l-proline hyperproduction
10.1038/s41467-022-28501-7 · 2022 · External reference
Production of riboflavin and related cofactors by biotechnological processes
10.1186/s12934-020-01302-7 · 2020 · External reference
Multiplex base editing of RBSs rewires Bacillus subtilis metabolism for lycopene overproduction
10.1016/j.ymben.2025.10.005 · 2025 · External reference
Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme in Escherichia coli
10.1073/pnas.1716056115 · 2018 · External reference
pH-Dependent Gating in a FocA Formate Channel
10.1126/science.1199098 · 2011 · External reference
Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems
10.3389/fbioe.2022.913077 · 2022 · External reference
The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress
10.1111/mmi.12967 · 2015 · External reference
NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems
10.1038/s41467-023-38739-4 · 2023 · External reference
Application of combinatorial optimization strategies in synthetic biology
10.1038/s41467-020-16175-y · 2020 · External reference
What is flux balance analysis?
10.1038/nbt.1614 · 2010 · External reference
Bioinspired Applications of Porphyrin Derivatives
10.1021/acs.accounts.1c00114 · 2021 · External reference
Constraint-based model of Shewanella oneidensis MR-1 metabolism: a tool for data analysis and hypothesis generation
10.1371/journal.pcbi.1000822 · 2010 · External reference
Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes
10.1021/acs.chemrev.7b00650 · 2018 · External reference
The Ribosome Binding Site Calculator
10.1016/b978-0-12-385120-8.00002-4 · 2011 · External reference
Classic highlights in porphyrin and porphyrinoid total synthesis and biosynthesis
10.1039/c7cs00719a · 2021 · External reference
5-aminolevulinic acid biosynthesis in Escherichia coli coexpressing NADP-dependent malic enzyme and 5-aminolevulinate synthase
2007 · External reference
Engineering Escherichia coli for High-Yield Protoporphyrin IX Biosynthesis via Cytotoxicity Mitigation and Pathway Optimization
10.1021/acssynbio.5c00302 · 2025 · External reference
Coproporphyrin production by Rhodobacter sphaeroides under aerobic in the dark and dissolved-oxygen-controlled conditions
10.1023/a:1023257228152 · 2003 · External reference
Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110
10.1128/aem.60.10.3724-3731.1994 · 1994 · External reference
Secretion of Flavins by Shewanella Species and Their Role in Extracellular Electron Transfer
10.1128/aem.01387-07 · 2008 · External reference
Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
10.1038/nature08610 · 2009 · External reference
Modularized Engineering of Shewanella oneidensis MR-1 for Efficient and Directional Synthesis of 5-Aminolevulinic Acid
10.1016/j.ymben.2024.05.001 · 2024 · External reference
ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli
10.1021/sb300016b · 2012 · External reference
Sustainable production of porphyrins through synthetic biology
10.1016/j.tibtech.2024.09.009 · 2025 · External reference
Multi-dimensional experimental and computational exploration of metabolism pinpoints complex probiotic interactions
10.1016/j.ymben.2023.01.008 · 2023 · External reference
Recent advances in microbial production of high-value compounds in the tetrapyrrole biosynthesis pathway
10.1016/j.biotechadv.2021.107904 · 2022 · External reference
Metabolic engineering of Escherichia coli for secretory production of free haem
10.1038/s41929-018-0126-1 · 2018 · External reference
Systematic development of a highly efficient cell factory for 5-aminolevulinic acid production
10.1016/j.tibtech.2024.06.004 · 2024 · External reference
Enhancing 5-aminolevulinic acid tolerance and production by engineering the antioxidant defense system of Escherichia coli
10.1002/bit.26981 · 2019 · External reference
