Research graph
References from Multimodal Technology-Driven aging Research: Decoding the Mitochondria‒Pyroptosis axis in muscle atrophy and cognitive decline. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence of Alzheimer's disease pathology in the community
10.1038/s41586-025-09841-y · 2026 · External reference
Sarcopenia: revised European consensus on definition and diagnosis
10.1093/ageing/afz046 · 2019 · External reference
Integrative physiology of skeletal muscle for maintaining cognitive health
10.1113/jp286748 · 2026 · External reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · 2012 · External reference
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation
10.1016/j.immuni.2024.10.012 · 2025 · External reference
10.1016/j.immuni.2023.10.004
10.1016/j.immuni.2023.10.004 · External reference
10.1016/j.cell.2024.10.019
10.1016/j.cell.2024.10.019 · External reference
Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems
10.1038/s43587-025-00958-3 · 2025 · External reference
Mitochondrial control of inflammation
10.1038/s41577-022-00760-x · 2023 · External reference
Apoptotic stress causes mtDNA release during senescence and drives the SASP
10.1038/s41586-023-06621-4 · 2023 · External reference
Mechanisms and therapeutic potential of the cGAS-STING signaling pathway in macrophage activation and polarization
2026 · External reference
The cGAS-STING signaling pathway: a central regulator and novel therapeutic target in skeletal muscle pathophysiology
10.1016/j.bcp.2026.117854 · 2026 · External reference
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease
10.1016/j.tibs.2025.07.007 · 2025 · External reference
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
10.1016/j.cell.2013.02.054 · 2013 · External reference
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
10.1016/j.immuni.2013.08.001 · 2013 · External reference
Mitochondrial Quality Control Processes at the Crossroads of Cell Death and Survival: Mechanisms and Signaling Pathways
10.3390/ijms25137305 · 2024 · External reference
Cryo-EM structures of the active NLRP3 inflammasome disc
10.1038/s41586-022-05570-8 · 2023 · External reference
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
10.1038/s41586-022-04467-w · 2022 · External reference
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
10.1038/s41586-019-1295-z · 2019 · External reference
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
10.1016/j.cell.2021.11.011 · 2021 · External reference
Droplet-based digital PCR (ddPCR) and its applications
10.1016/j.trac.2022.116897 · 2023 · External reference
Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution
10.1101/gr.250480.119 · 2019 · External reference
Effect of aging, endurance training, and denervation on innate immune signaling in skeletal muscle
10.1152/japplphysiol.00038.2025 · 2025 · External reference
Editorial: Role of pyroptosis in neurological disorders and its therapeutic approaches
10.3389/fnagi.2023.1253644 · 2023 · External reference
Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
10.1073/pnas.1409328111 · 2014 · External reference
The Theoretical Basis of qPCR and ddPCR Copy Number estimates: a critical Review and Exposition
10.3390/w17030381 · 2025 · External reference
Global trends in the application of droplet digital PCR technology in the field of infectious disease pathogen diagnosis: a bibliometric analysis from 2012 to 2023
10.1016/j.diagmicrobio.2024.116623 · 2025 · External reference
Mitochondrial-Derived Vesicles: the good, the bad, and the Ugly
10.3390/ijms241813835 · 2023 · External reference
Extracellular blebs: Artificially-induced extracellular vesicles for facile production and clinical translation
10.1016/j.ymeth.2019.11.007 · 2020 · External reference
Exosomal Tenascin-C primes macrophage pyroptosis amplifying aberrant inflammation during sepsis-induced acute lung injury
10.1016/j.trsl.2024.04.001 · 2024 · External reference
Mitochondria-Derived Vesicles, Sterile Inflammation, and Pyroptosis in Liver Cancer: Partners in Crime or innocent Bystanders?
10.3390/ijms25094783 · 2024 · External reference
Roles of extracellular vesicles in the aging microenvironment and age-related diseases
10.1002/jev2.12154 · 2021 · External reference
Colloidal gold ultraimmunocytochemical localization of DNA and RNA adducts in rat hepatocytes
10.1093/carcin/13.12.2335 · 1992 · External reference
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
10.1038/s41467-021-21984-w · 2021 · External reference
Correction to “Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial damage and Inflammation by stabilizing Mitochondrial DNA”
10.1021/acsnano.1c09895 · 2021 · External reference
The role of extracellular vesicles in pyroptosis-mediated infectious and non-infectious diseases
10.1016/j.intimp.2024.112633 · 2024 · External reference
Extracellular vesicles (EVs): Comprehensive packages with promises and complications for clinical translation and commercialization
10.1016/j.ymeth.2020.03.001 · 2020 · External reference
Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy
10.1016/j.bcp.2022.114954 · 2022 · External reference
Mitochondria and cell death
10.1038/s41556-024-01429-4 · 2024 · External reference
Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin
10.1038/s41392-025-02450-1 · 2025 · External reference
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism
10.1161/circresaha.120.318805 · 2021 · External reference
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions
10.1038/s41392-025-02502-6 · 2025 · External reference
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
10.1038/s41392-025-02253-4 · 2025 · External reference
Immune Aging as a failure of Programmed Cell Death Coordination
10.3390/ijms27031554 · 2026 · External reference
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells
10.1007/s11357-022-00550-2 · 2022 · External reference
TXNIP-Deficiency and Prdx6 delivery Inhibit Aging/Oxidative Stress-Driven TXNIP-Nlrp3 Inflammasome Activation and Mitigate Pyroptosis in Lens Epithelial Cells
2026 · External reference
Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease
10.1159/000511207 · 2020 · External reference
Organ reserve, excess metabolic capacity, and aging
10.1007/s10522-018-9746-8 · 2018 · External reference
The gasdermins, a protein family executing cell death and inflammation
10.1038/s41577-019-0228-2 · 2020 · External reference
Pore formation by GSDMD is the effector mechanism of pyroptosis
10.15252/embj.201695415 · 2016 · External reference
Mechanism of membrane pore formation by human gasdermin-D
10.15252/embj.201798321 · 2018 · External reference
GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets
10.1186/s43556-025-00249-8 · 2025 · External reference
Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin is a Novel Approach for Senolysis
10.3390/ijms232214251 · 2022 · External reference
D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
10.1016/j.devcel.2023.11.017 · 2024 · External reference
A Mechanistic Understanding of Pyroptosis: the fiery Death Triggered by Invasive Infection
10.1016/bs.ai.2017.02.002 · 2017 · External reference
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
10.1038/s41418-018-0106-7 · 2019 · External reference
Mitochondrial dysfunction drives cellular senescence: Molecular mechanisms of inter-organelle communication
10.1016/j.exger.2025.112913 · 2025 · External reference
Mitochondria in pyroptosis: Mechanisms and implications
10.1016/j.molimm.2025.12.002 · 2026 · External reference
Imperfect repair in aging: senescent cells and the hepatic fibrotic niche
10.5483/bmbrep.2025-0224 · 2026 · External reference
10.1101/2025.11.23.689860
10.1101/2025.11.23.689860 · External reference
Vascular Niches are the Primary Hotspots in Cardiac Aging
10.1161/circresaha.125.327060 · 2025 · External reference
Niche-specific dermal macrophage loss promotes skin capillary ageing
10.1038/s41586-025-09639-y · 2025 · External reference
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence
2026 · External reference
Gasdermin D-mediated metabolic crosstalk promotes tissue repair
10.1038/s41586-024-08022-7 · 2024 · External reference
Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons
10.1007/s00401-022-02528-y · 2023 · External reference
The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects
10.1016/j.bcp.2026.118025 · 2026 · External reference
A multi-tiered μDicer with hierarchical blades achieves protein-preserving microdissection down to 10 μm
2025 · External reference
Immuno-laser capture microdissection of perfusion-fixed mouse brain tissue coupled to RNA-seq
10.1016/j.jneumeth.2025.110548 · 2025 · External reference
Optimized Method for Robust Transcriptome Profiling of Minute Tissues using Laser Capture Microdissection and Low-Input RNA-Seq
10.3389/fnmol.2017.00185 · 2017 · External reference
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
10.1016/j.cell.2024.11.018 · 2025 · External reference
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death
10.1038/s41556-025-01774-y · 2025 · External reference
Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescence, Inflammaging, and Therapeutic Opportunities in Aging and Age-Related Diseases
2026 · External reference
Gasdermin pores on extracellular vesicles spread cell death
2025 · External reference
Automated Targeted Sectioning of Resin-embedded Hard Tissue Specimen using Micro-Computed Tomography in Combination with Laser Microtomy
2025 · External reference
Symphony of regulated cell death: Unveiling therapeutic horizons in sarcopenia
10.1016/j.metabol.2025.156359 · 2025 · External reference
Dual role of macrophages in skeletal muscle atrophy: Mechanisms and therapeutic strategies
10.1016/j.bcp.2025.117589 · 2026 · External reference
Molecular mechanisms of skeletal muscle atrophy: clinical challenges and future therapeutic strategies
10.1016/j.bcp.2026.117913 · 2026 · External reference
Oxidative stress: Roles in skeletal muscle atrophy
10.1016/j.bcp.2023.115664 · 2023 · External reference
Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy
10.1016/j.bcp.2025.116799 · 2025 · External reference
NLRP3 Inflammasome-Mediated Pyroptosis in Osteoporosis: Osteoimmune Mechanisms and Therapeutic Targeting
10.1111/jcmm.70798 · 2025 · External reference
Osteosarcopenia: key molecular mechanisms and translational perspectives
2025 · External reference
The Inflammation-Energy Metabolism Axis: a Central driver of Sarcopenia-Osteoporosis: a Narrative Review
10.1007/s00223-025-01473-8 · 2026 · External reference
Karyoptosis as a novel type of UVB-induced regulated cell death
10.1080/10715762.2024.2433986 · 2024 · External reference
Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections
10.1038/s41413-024-00387-9 · 2025 · External reference
Assessment of decalcification solutions on cellular morphology and immunostaining of mouse bones
10.1080/01478885.2025.2583646 · 2025 · External reference
Design and optimization of caspase-1-responsive fluorescent probes for pyroptosis imaging and anti-pyroptosis drug screening
10.1039/d5sc07690k · 2026 · External reference
Innovative Nanotechnology and Molecular Probes for Real-time monitoring and Therapeutic Modulation of Pyroptosis in Cancer and Inflammatory Diseases
10.1007/s12013-025-01868-2 · 2025 · External reference
Potential Role of Inflammasomes in Aging
10.3390/ijms26146768 · 2025 · External reference
Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing
10.1038/s41467-025-63905-1 · 2025 · External reference
10.1002/advs.202517554
10.1002/advs.202517554 · External reference
Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance
2025 · External reference
The dual Role of Interleukin-6 in the Pathophysiology of Skeletal Muscle: Mechanisms, challenges, and Therapeutic prospects
10.3390/ph19060868 · 2026 · External reference
Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system
10.1186/s12974-024-03140-5 · 2024 · External reference
Novel Optical Imaging Probe for the Targeted Visualization of NLRP3 Inflammasomes in living Retina
10.1021/acs.jmedchem.5c00999 · 2025 · External reference
Amyloid-β-induced pyroptosis drives retinal neurodegeneration in a TgAPPswePS1 mouse model
10.18240/ijo.2025.11.03 · 2025 · External reference
Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs
2026 · External reference
A Caspase-1-cathepsin AND-Gate Probe for Selective Imaging of Inflammasome Activation
10.1021/acschembio.5c00408 · 2025 · External reference
The role of DXA in sarcopenia
10.1007/s40520-016-0589-3 · 2016 · External reference
The recent development, application, and future prospects of muscle atrophy animal models
10.1002/mef2.70008 · 2024 · External reference
TLR/NLRP3 inflammasome signaling pathways as a main target in frailty, cachexia and sarcopenia
10.1016/j.tice.2025.102723 · 2025 · External reference
Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway
10.1007/s12017-025-08889-3 · 2025 · External reference
Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway
10.3389/fnagi.2025.1628520 · 2025 · External reference
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice
10.1038/s41467-025-63456-5 · 2025 · External reference
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway
10.1038/s41419-025-08025-w · 2025 · External reference
Short-chain fatty acids alleviate sarcopenia in rats via modulation of the NF-κB signaling pathway
2026 · External reference
Optimizing Bothropstoxin-I-Derived Peptides: Exploring the Antibacterial potential of p-BthW
10.1021/acsomega.4c01303 · 2024 · External reference
NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation
10.1038/s42003-025-09501-x · 2026 · External reference
Hindlimb Immobilization increases IL-1β and Cdkn2a expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: a link between Senescence and Muscle Disuse Atrophy. Front Cell
2021 · External reference
Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling
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10.64898/2025.12.04.692337 · External reference
Physiological and injury-induced microglial dynamics across the lifespan
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Acid-Responsive Linear Polyethylenimine for Efficient, specific, and Biocompatible siRNA delivery
10.1021/bc800436v · 2009 · External reference
Platycodin D3 protects against sepsis-associated acute lung injury through direct inhibition of the PKM2-NLRP3 axis
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An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening
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High-Throughput Screening for Ageing and Age-Related Disease Drug Discovery: advances and challenges
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Progress in Precision Drug delivery Systems for Neurodegenerative Diseases with Muscle Atrophy
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Cancer nanotechnology: current status and perspectives
10.1186/s40580-021-00282-7 · 2021 · External reference
Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning
2025 · External reference
Using Blood-based Biomarkers to Facilitate the Diagnosis of Alzheimer’s Disease: Insights from a Novel Pyroptosis-Associated Molecular Signature Model
10.1007/s12035-025-05212-w · 2025 · External reference
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
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Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens
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Antimicrobial activity of an Fmoc-Plantaricin 149 Derivative Peptide against Multidrug-Resistant Bacteria
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