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References from Establishment of Expanded Botanical Thresholds of Toxicological Concern: Enrichment of Botanical PoD Databases and New Thresholds. Local targets link to admitted publications; unresolved targets remain external evidence.
Natural products in drug discovery: advances and opportunities
10.1038/s41573-020-00114-z · 2021 · External reference
Techniques for extraction of bioactive compounds from plant materials: A review
10.1016/j.jfoodeng.2013.01.014 · 2013 · External reference
Threshold of toxicological concern—an update for non-genotoxic carcinogens
10.3389/ftox.2021.688321 · 2021 · External reference
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Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment
10.3109/10408444.2010.543655 · 2011 · External reference
The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure
10.1016/j.yrtph.2021.104964 · 2021 · External reference
Safe usage levels of aqueous Hippophae rhamnoides fruit extract in cosmetics estimated by threshold of toxicological concern, point of departure, and history of safe consumption
10.1016/j.yrtph.2025.105961 · 2026 · External reference
fitdistrplus: An R package for fitting distributions
10.18637/jss.v064.i04 · 2015 · External reference
Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC)
2012 · External reference
Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment
10.2903/j.efsa.2019.5708 · 2019 · External reference
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Safety evaluation of the mixture of chemicals at a specific workplace: theoretical considerations and a suggested two-step procedure
10.1016/0378-4274(94)03193-2 · 1995 · External reference
Development of a consensus approach for botanical safety evaluation–A roundtable report
10.1016/j.toxlet.2019.05.008 · 2019 · External reference
Safety Assessment of Sophora flavescens Root Extract for Cosmetic Use: An Integrated Approach Using In Vitro, In Silico MoS, TTC, and History of Safe Use
10.3390/toxics14050398 · 2026 · External reference
Assessment of Systemic Safety of Althaea rosea Flower Extract for Use in Cosmetics: Threshold of Toxicological Concern and History of Safe Consumption Approaches
10.3390/cosmetics12040133 · 2025 · External reference
Safety assessment of botanicals: cutting through complexity
10.1016/j.cofs.2025.101313 · 2025 · External reference
Assessment of local and systemic safety of aqueous Eucommia ulmoides bark extract for a cosmetics ingredient utilizing in vitro, in silico, threshold of toxicological concern and history of safe use approaches
10.1016/j.yrtph.2026.106157 · 2026 · External reference
Safety assessment of Cnidium officinale rhizome extract in cosmetics using the Threshold of Toxicological Concern (TTC) approach
10.1016/j.yrtph.2023.105433 · 2023 · External reference
Safety assessment of Paeonia lactiflora root extract for a cosmetic ingredient employing the threshold of toxicological concern (TTC) approach
10.1016/j.yrtph.2024.105620 · 2024 · External reference
Assessment of herbal medicinal products: challenges, and opportunities to increase the knowledge base for safety assessment
10.1016/j.taap.2009.12.005 · 2010 · External reference
Threshold of Toxicological Concern (TTC) for Botanical Extracts (Botanical-TTC) derived from a meta-analysis of repeated-dose toxicity studies
10.1016/j.toxlet.2019.08.006 · 2019 · External reference
Risk assessment of cyclohexasiloxane D6 in cosmetic products
10.1007/s43188-024-00235-2 · 2024 · External reference
Which is most sensitive? Assessing responses of mice and rats in toxicity bioassays
10.1080/15287394.2018.1423799 · 2018 · External reference
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
10.1016/j.fct.2003.08.006 · 2004 · External reference
Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern
10.1016/s0278-6915(96)00049-x · 1996 · External reference
Evaluating potential refinements to existing Threshold of Toxicological Concern (TTC) values for environmentally-relevant compounds
10.1016/j.yrtph.2019.104505 · 2019 · External reference
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A tiered approach for the evaluation of the safety of botanicals used as dietary supplements: an industry strategy
10.1002/cpt.1132 · 2018 · External reference
Chemical mixtures: current risk assessment methodologies and future directions
10.1006/rtph.1995.1071 · 1995 · External reference
A general theory of effect size, and its consequences for defining the benchmark response (BMR) for continuous endpoints
10.1080/10408444.2016.1241756 · 2017 · External reference
Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts
10.3390/molecules14062167 · 2009 · External reference
An introduction to the bootstrap
1993 · External reference
Advancing botanical safety: a strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
10.1016/j.fct.2024.114537 · 2024 · External reference
Synergy and other interactions in phytomedicines
10.1078/0944-7113-00060 · 2001 · External reference
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Development of a new threshold of toxicological concern database of non-cancer toxicity endpoints for industrial chemicals
10.3389/ftox.2021.626543 · 2021 · External reference
Thresholds of Toxicological Concern for cosmetics-related substances: new database, thresholds, and enrichment of chemical space
10.1016/j.fct.2017.08.043 · 2017 · External reference
