Research graph
References from Sporadic Amyotrophic Lateral Sclerosis: Brief Pathogenic Review and a New Causal Hypothesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
10.1038/aps.2009.24 · 2009 · External reference
Excitotoxity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons? Amyotroph
10.1080/14660820510037872 · 2005 · External reference
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
10.1093/brain/awm190 · 2007 · External reference
In vitro neurotoxic properties and excitatory aminoacid concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
10.1111/j.1600-0404.2009.01200.x · 2010 · External reference
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
10.1002/ana.410380114 · 1995 · External reference
Regulation and dysregulation of glutamate transporters
10.1007/3-540-29784-7_14 · 2006 · External reference
Epigenetic regulation of neuron dependent induction of astroglial synaptic protein GLT1
10.1002/glia.20922 · 2010 · External reference
Oxidative stress in ALS: key role in motor neuron injury and therapeutic target
10.1016/j.freeradbiomed.2009.11.018 · 2010 · External reference
Neuronal death in amyotrophic lateral sclerosis (ALS): what can we learn from ge-netics? CNS Neurol
10.2174/187152710791292558 · 2010 · External reference
SOD1 gene mutations in Italian patients with Sporadic Amyotrophic Lateral Sclerosis (ALS
10.1016/j.nmd.2006.07.004 · 2006 · External reference
Cu/Zn supertoxide dismutase ac-tivity at different ages is sporadic amyotrophic lateral sclerosis
10.1016/s0022-510x(98)00272-x · 1999 · External reference
SOD1 RNA expression in sporadic amyotrophic lateral sclerosis
10.1016/j.nbd.2010.04.008 · 2010 · External reference
Glutamate toxicity in rat cerebellar granullae cells: a major role for xantine oxidase in oxigen radical formation
10.1046/j.1471-4159.1997.68052038.x · 1997 · External reference
Production of reactive oxygen species by mitochondria: central role of complex
10.1074/jbc.m304854200 · 2003 · External reference
Familial amyotrophic lateral sclerosis
1995 · External reference
A gain of function of an amy-otrophic lateral sclerosis-associated Cu/Zn superoxide dismutase mutant: an enhancement of free radical formation
10.1073/pnas.93.12.5709 · 1996 · External reference
Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
10.1093/hmg/ddp421 · 2009 · External reference
Mitochondrial alterations in the spinal cord ofpatients with sporadic amyotrophic lateral sclerosis
10.1097/nen.0b013e31802c396b · 2007 · External reference
Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosis
10.1590/s0004-282x2012000100010 · 2012 · External reference
Total antioxidant status is increased in the serum of amyotrophic lateral sclerosis patients
10.1080/00365510310001771 · 2003 · External reference
Endogenous progesterone is associated to amyotrophic lateral sclerosis prognostic factors
10.1111/j.1600-0404.2010.01385.x · 2011 · External reference
Proteasome inhibition induces selective motor neuron death in organotypic slice cultures
10.1002/jnr.20665 · 2005 · External reference
Molecular basis of amyotrophic lateral sclerosis
10.1016/j.pnpbp.2010.07.017 · 2011 · External reference
Progressive motor weakness in transgenic mice expressing human TDP-43
10.1016/j.nbd.2010.06.017 · 2010 · External reference
Wobbler mice modelling motor neuron disease display elevated transactive response DNA binding protein
10.1016/j.neuroscience.2008.10.030 · 2009 · External reference
Broad clinical phenotypes associated with TAR- DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis
10.1007/s10048-009-0218-9 · 2010 · External reference
Mutations of FUS Gene in Sporadic Amyotrophic Lateral Sclerosis
10.1136/jmg.2009.071027 · 2010 · External reference
From FUS to Fibs: what’s new in frontotemporal dementia
10.3233/jad-2010-091513 · 2010 · External reference
Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations
10.1001/archneurol.2011.178 · 2011 · External reference
Cerebro-spinal fluid from sporadic amyotrophic lateral sclerosis patients induces degeneration of a cultured motor neuron cell line
10.1016/j.brainres.2009.01.041 · 2009 · External reference
Low grade systemic inflammation in patients with amyotrophic lateral sclerosis
10.1111/j.1600-0404.2008.01112.x · 2009 · External reference
Microglia in ALS: the good, the bad and the resting
10.1007/s11481-009-9171-5 · 2009 · External reference
Inflammation in ALS and SMA: sorting out the good from the evil
10.1016/j.nbd.2009.10.005 · 2010 · External reference
A genome wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis
10.3109/17482960802635397 · 2009 · External reference
Mutations of optineurin in amyotrophic lateral sclerosis
10.1038/nature08971 · 2010 · External reference
The Chromosome 9-ALS/FTD Consortium, The Frenche Research Network of FTLD/FTLD/ALS, The ITALSGEN Consotium
2012 · External reference
What of apoptosis is important: the decay process or the causative origin? Med
10.1016/j.mehy.2007.07.006 · 2008 · External reference
Progesterone neuroprotection in the wobbler mouse, a genetic model of spinal cord motor neuron disease
10.1006/nbdi.2002.0564 · 2002 · External reference
Review: autophagy and neurodegeneration: survival at a cost? Neuropathol
10.1111/j.1365-2990.2010.01062.x · 2010 · External reference
Focality of upper and lower motor neuron degeneration at the clinical onset of ALS
10.1212/01.wnl.0000260965.20021.47 · 2007 · External reference
Implications of ALS focality
10.1212/01.wnl.0000261045.57095.56 · 2007 · External reference
Regional spread pattern affects prognosis in patient with amyotrophic lateral sclerosis. Eur. J. Neurol
2012 · External reference
A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS
10.1212/01.wnl.0000263188.77797.99 · 2007 · External reference
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate
10.1212/01.wnl.0000297552.13219.b4 · 2008 · External reference
Reversible ALS-like disorder in HIV infection
10.1212/wnl.57.6.995 · 2001 · External reference
Study of the aetiology of amyotrophic lateral sclerosis
1963 · External reference
Identification of active loci of a human endogenous retro-virus in neurons of patients with amyotrophic lateral sclerosis
10.1002/ana.22149 · 2011 · External reference
Morphometric quantification of the cervical limb motor cells in controls and in amyotrophic lateral sclerosis
10.1016/0022-510x(79)90089-3 · 1979 · External reference
Astrocyte control of synaptic transmission and neurovascular coupling
10.1152/physrev.00049.2005 · 2005 · External reference
Determinants of regional and local diversity within the astroglial lineage of normal central nervous system
10.1111/j.1471-4159.2009.06288.x · 2009 · External reference
Surface CD2, CD4, CD8 markers and IL-2 and TNF-alpha cyto-kines in amyotrophic lateral sclerosis
2001 · External reference
Extensive astrocyte infection is prominent in human immunodeficiency virus associated dementia
10.1002/ana.21697 · 2009 · External reference
Distribution of apoptosis related proteins in sporadic Creutzfeldt-Jakob disease
10.1016/j.brainres.2010.01.089 · 2010 · External reference
Is the spinal cord motoneuron exclusively a target in ALS? Comparison between astroglial reactivity in a rat model of familial ALS and in human sporadic ALS cases
2011 · External reference
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
10.1038/nbt.1957 · 2011 · External reference
Astrogliosis in ALS: possible interpretation according to pathogenic hypothesis
10.1080/14660820310016822 · 2004 · External reference
In vitro differences between astrocytes of control and Wobbler mice spinal cord
10.1023/a:1021199931682 · 1999 · External reference
