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References from Genetic alterations and biological pathways in human bladder cancer pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathways of development and progression in bladder cancer
1993 · External reference
Biology of disease—urinary bladder cancer
1994 · External reference
Molecular genetics of bladder cancer
1995 · External reference
Genetic studies and molecular markers of bladder cancer (Review)
10.1002/(sici)1098-2388(199709/10)13:5<319::aid-ssu5>3.0.co;2-g · 1997 · External reference
Unresolved reference
External reference
Epidemiological characteristics of squamous cell carcinoma and adenocarcinoma of the bladder
1988 · External reference
10.1007/978-1-4471-1362-1
10.1007/978-1-4471-1362-1 · External reference
Unresolved reference
External reference
Systemic chemotherapy of transitional cell carcinoma of the urothelium
10.1002/(sici)1098-2388(199709/10)13:5<365::aid-ssu11>3.0.co;2-m · 1997 · External reference
Combined-modality therapy for bladder cancer
1997 · External reference
Clonal origin of bladder cancer
10.1056/nejm199203123261104 · 1992 · External reference
Clonal analysis of human recurrent superficial bladder cancer by immunohistochemistry of p53 and retinoblastoma proteins
10.1016/s0022-5347(01)65550-2 · 1996 · External reference
Mosaicism in human epithelium
10.1016/s0022-5347(01)67507-4 · 1995 · External reference
Recurrences and progression of superficial bladder cancer following long-term intravesical prophylactic therapy with mitomycin CB 48-month follow-up
10.1159/000282849 · 1996 · External reference
Natural history of superficial bladder tumors B 10- to 20-year follow-up of treated patients
10.1007/bf02201977 · 1997 · External reference
The treated natural history of high risk superficial bladder cancer
10.1097/00005392-199707000-00017 · 1997 · External reference
Reassessment of conservative management for stage T1N0M0 transitional cell carcinoma of the bladder
10.1016/s0022-5347(01)66043-9 · 1996 · External reference
Two molecular pathways to transitional cell carcinoma of the bladder
1994 · External reference
A molecular genetic model of human bladder cancer pathogenesis
1996 · External reference
Review of chromosome studies in urological tumors. II. Cytogenetics and molecular genetics of bladder cancer
10.1016/s0022-5347(17)35014-0 · 1994 · External reference
Cytogenetics of bladder cancer
10.1016/s0165-4608(96)00295-6 · 1997 · External reference
Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization
10.1002/gcc.2870120309 · 1995 · External reference
Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization
1997 · External reference
Genetic alterations in primary bladder cancers and their metastases
1998 · External reference
Accumulated allelic losses in the development of invasive urothelial cancer
10.1002/ijc.2910530409 · 1993 · External reference
Allelotype of human bladder cancer
1994 · External reference
Molecular genetic alterations in superficial and locally advanced human bladder cancer
1991 · External reference
Chromosome 3 allelic losses and microsatellite alterations in transitional cell carcinoma of the urinary bladder
1996 · External reference
Overcoming cellular senescence in human cancer pathogenesis
10.1101/gad.12.2.163 · 1998 · External reference
Fluorescence in situ hybridization deletion mapping at 4p16.3 in bladder cancer cell lines refines the localization of the critical interval to 30 kb
10.1002/(sici)1098-2264(199610)17:2<108::aid-gcc6>3.0.co;2-9 · 1996 · External reference
Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer
1991 · External reference
Deletion mapping implicates two tumor suppressor genes on chromosomes 8p in the development of bladder cancer
1996 · External reference
Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer
1997 · External reference
c-myc copy number gains in bladder cancer detected by fluorescence in situ hybridization
1995 · External reference
Evidence for two bladder cancer suppressor loci on human chromosome 9
1993 · External reference
Preliminary mapping of the deleted region of chromosome 9 in bladder cancer
1993 · External reference
Role of chromosome 9 in human bladder cancer
1993 · External reference
Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors
1994 · External reference
Detailed deletion mapping of chromosome 9q in bladder cancer
1995 · External reference
Evidence for two tumor suppresor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations
1996 · External reference
A novel candidate tumour suppressor locus at 9q32-q33 in bladder cancer
10.1093/hmg/6.6.913 · 1997 · External reference
Homozygous deletions within chromosomal bands 9p21-22 in bladder cancer
1994 · External reference
p16 gene in uncultured tumours
1994 · External reference
Rates of p16 (MTS1) mutations in primary tumors with 9p Loss
10.1126/science.8023167 · 1994 · External reference
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
10.1038/ng1095-210 · 1995 · External reference
p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer
10.1093/hmg/4.9.1569 · 1995 · External reference
Frequent homozygous deletion of cyclin-dependent kinase inhibitor 2 (MTSI, p16) in superficial bladder cancer detected by fluorescence in situ hybridization
10.1002/(sici)1098-2264(199706)19:2<84::aid-gcc3>3.0.co;2-w · 1997 · External reference
Infrequent somatic alteration of p16/MTS1 in human primary superficial bladder cancers
10.1016/0304-3835(96)04225-5 · 1996 · External reference
Homozygous deletions of p16(INK4) occur frequently in bilharziasis-associated bladder cancer
10.1002/(sici)1097-0215(19961009)68:2<183::aid-ijc7>3.0.co;2-u · 1996 · External reference
Cluster of allele losses within a 2.5 cM region of chromosome 10 in high-grade invasive bladder cancer
10.1038/sj.onc.1201606 · 1998 · External reference
Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder
10.1038/sj.onc.1201154 · 1997 · External reference
Deletion mapping of chromosome 11 in carcinoma of the bladder
10.1002/gcc.2870130102 · 1995 · External reference
Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder
1990 · External reference
Y chromosome loss detected by FISH in bladder cancer
10.1016/0165-4608(95)00030-s · 1995 · External reference
Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas
1991 · External reference
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression
10.1002/ijc.2910530513 · 1993 · External reference
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Letters to Nature
10.1038/366704a0 · 1993 · External reference
High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder
10.1093/jnci/87.18.1383 · 1995 · External reference
Distinct pattern of p53 mutations in bladder cancer
1993 · External reference
Identification of p53 gene mutations in bladder cancers and urine samples
10.1126/science.2024123 · 1991 · External reference
The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14
1996 · External reference
Identification and characterization of the familial adenomatous polyposis coli gene
10.1016/0092-8674(81)90021-0 · 1991 · External reference
Role of Mxi1 in aging organ systems and the regulation of normal and neoplastic growth. Letters to Nature
10.1038/31008 · 1998 · External reference
p57KIP2, a structurally distinct member of the p21CIP1 cdk inhibitor family, is a candidate tumor suppressor gene
10.1101/gad.9.6.650 · 1995 · External reference
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
10.1126/science.271.5247.350 · 1996 · External reference
Function of a human cyclin gene as an oncogene
10.1073/pnas.91.2.709 · 1994 · External reference
Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers
10.1038/bjc.1997.305 · 1997 · External reference
Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder
10.1038/bjc.1991.211 · 1991 · External reference
Prevalence and clinical significance of HER-2/NEU, p53 and RB expression in primary superficial bladder cancer
10.1016/s0022-5347(01)66198-6 · 1996 · External reference
Positional cloning of ZNF217 and NABC1
10.1073/pnas.95.15.8703 · 1998 · External reference
Significance of urinary epidermal growth factor and its receptor expression in human bladder cancer
1997 · External reference
Myc activates telomerase
10.1101/gad.12.12.1769 · 1998 · External reference
Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells
1996 · External reference
Replicative senescence in human uroepithelial cells
1998 · External reference
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
1996 · External reference
Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells
10.1101/gad.8.18.2227 · 1994 · External reference
Chromosomal changes during progression of transitional cell carcinoma of the bladder and delineation of the amplified interval on chromosome arm 8q
10.1002/(sici)1098-2264(199810)23:2<167::aid-gcc10>3.0.co;2-l · 1998 · External reference
Comparison of p53 protein overexpression with p53 mutation in bladder cancer
1995 · External reference
Analysis of p21WAF1/CIP1 in primary bladder tumors
1996 · External reference
Effect of p21(WAF1/CIP1) expression on tumor progression in bladder cancer
10.1093/jnci/90.14.1072 · 1998 · External reference
mdm2 promotes the rapid degradation of p53
10.1038/387296a0 · 1997 · External reference
Interaction between the retinoblastoma protein and the oncoprotein mdm2
10.1038/375694a0 · 1995 · External reference
Nuclear overexpression of p53 protein in transitional cell bladder carcinoma
10.1093/jnci/85.1.53 · 1993 · External reference
p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade and stage in bladder cancer
1993 · External reference
Accumulation of nuclear p53 and tumor progression in bladder cancer
10.1056/nejm199411103311903 · 1994 · External reference
Correlation of allelic loss of the p53 gene and tumor grade, stage, and malignant progression in bladder cancer
10.1111/j.1442-2042.1997.tb00144.x · 1997 · External reference
p53 accumulation, deoxyribonucleic acid ploidy and progression of bladder cancer
10.1016/s0022-5347(01)64939-5 · 1997 · External reference
Predictive value of p53 mutations analyzed in bladder washings for progression of high-risk superficial bladder cancer
1996 · External reference
p53 expression compared with other prognostic factors in OMS Grade-1 Stage-Ta transitional cell carcinoma of the bladder
10.1159/000480864 · 1997 · External reference
Immunohistochemical determination of p53 overexpression
10.1007/bf00942045 · 1997 · External reference
Evaluation of overexpression of p53 tumor suppressor protein in superficial and invasive transitional cell bladder cancer
10.1016/s0090-4295(99)80216-7 · 1995 · External reference
The prognostic value of p53 in superficially infiltrating transitional cell carcinoma
10.3109/00365599509180032 · 1995 · External reference
Overexpression of p53 protein and its significance for recurrent progressive bladder tumours
10.1046/j.1464-410x.1996.09386.x · 1996 · External reference
Reduced expression of retinoblastoma (Rb) gene protein is related to cell proliferation and prognosis in transitional-cell bladder cancer
10.1007/bf01202728 · 1995 · External reference
Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer
10.1093/jnci/84.16.1256 · 1992 · External reference
p53 and RB expression predict progression in T1 bladder cancer
1998 · External reference
Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors
1997 · External reference
Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53
1998 · External reference
Significance of epidermal growth factor receptor and c-erbB-2 protein expression in transitional cell cancer of the upper urinary tract for tumour recurrence at the urinary bladder
10.1038/bjc.1995.14 · 1995 · External reference
Heterogeneity of erbB-2 gene amplification in bladder cancer
1993 · External reference
Patterns of p53, erbB-2, and EGF-r expression in premalignant lesions of the urinary bladder
10.1016/0046-8177(95)90086-1 · 1995 · External reference
The epidermal growth factor receptor and the prognosis of bladder cancer
10.1002/1097-0142(19900401)65:7<1619::aid-cncr2820650728>3.0.co;2-q · 1990 · External reference
C-erbB-2 gene amplification
1995 · External reference
p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder cancer
10.1016/0046-8177(94)90096-5 · 1994 · External reference
Increased p16 levels correlate with pRb alterations in human urothelial cells
1995 · External reference
Induction of thioguanine-resistant mutations in human uroepithelial cells by 4-aminobiphenyl and its N-hydroxy derivatives
1992 · External reference
Tumorigenic transformation and neoplastic progression of human uroepithelial cells after exposure in vitro to 4-aminobiphenyl or its metabolites
1992 · External reference
Characterization of human uroepithelial cells immortalized in vitro by simian virus 40
1987 · External reference
Losses of 3p, 11p, and 13q in EJ/ras-transformable simian virus 40-immortalized human uroepithelial cells
10.1002/gcc.2870040210 · 1992 · External reference
Immortalization of human uroepithelial cells by human papillomavirus 16 E6 or E7
10.1002/roi.2970030623 · 1996 · External reference
20q gain associates with immortalization
10.1038/sj.onc.1200868 · 1997 · External reference
Apoptosis in human papillomavirus 16 E7-, but not E6-immortalized human uroepithelial cells
1996 · External reference
Tumor suppression at the mouse er locus mediated by the alternative reading frame product p19ARF
10.1016/s0092-8674(00)80452-3 · 1997 · External reference
The INK4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2's inhibition of p53
10.1016/s0092-8674(00)81400-2 · 1998 · External reference
p14ARF links the tumour suppressors RB and p53
1998 · External reference
p19ARF links the tumour suppressor p53 to RAS
1998 · External reference
Minimal deletion of 3p13614.2 associated with immortalization of human uroepithelial cells
10.1002/(sici)1098-2264(199801)21:1<39::aid-gcc6>3.0.co;2-9 · 1998 · External reference
Loss of 3p136p21.2 in tumorigenic reversion of a hybrid between isogeneic nontumorigenic and tumorigenic human uroepithelial cells
1992 · External reference
Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells
10.1002/gcc.2870030505 · 1991 · External reference
Neoplastic transformation of SV40-immortalized human urinary tract epithelial cells by in vitro exposure to 3-methylcholanthrene
10.1093/carcin/9.8.1427 · 1988 · External reference
In vitro radiation-induced neoplastic progression of low-grade uroepithelial tumors
10.2307/3578850 · 1994 · External reference
EJ/ras neoplastic transformation of simian virus 40-immortalized human uroepithelial cells
1990 · External reference
Neoplastic progression by EJ/ras at different steps of transformation in vitro of human uroepithelial cells
1992 · External reference
Nonrandom chromosome losses in stepwise neoplastic transformation in vitro of human uroepithelial cells
1991 · External reference
Addressing the significance of chromosome-loss data
10.1002/sim.4780130805 · 1994 · External reference
Role of SV40 T antigen binding to pRB and p53 in multistep transformation in vitro of human uroepithelial cells
10.1093/carcin/14.11.2297 · 1993 · External reference
Nonrandom chromosome losses in tumorigenic revertants of hybrids between isogenic immortal and neoplastic human uroepithelial cells
10.1007/bf01233620 · 1991 · External reference
Chromosome losses in tumorigenic revertants of EJ/ras-expressing somatic cell hybrids
10.1016/0165-4608(92)90213-r · 1992 · External reference
Telomerase activity
10.1073/pnas.94.25.13677 · 1997 · External reference
Detection of telomerase activity in exfoliated cells in urine from patients with bladder cancer
10.1093/jnci/89.10.724 · 1997 · External reference
Detecting human bladder carcinoma cells in voided urine samples by assaying for the presence of telomerase activity
10.1002/(sici)1097-0142(19980215)82:4<708::aid-cncr14>3.0.co;2-1 · 1998 · External reference