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References from Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity. Local targets link to admitted publications; unresolved targets remain external evidence.
Head and neck cancer
10.1056/nejm199301213280306 · 1993 · External reference
Estimates of the worldwide frequency of sixteen major cancers in 1980
10.1002/ijc.2910410205 · 1988 · External reference
The high risk human papillomaviruses and oral cancer
10.1111/j.1601-0825.1997.tb00025.x · 1997 · External reference
The INK4A/ARF locus and its two gene products
10.1016/s0959-437x(99)80004-5 · 1999 · External reference
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
10.1093/emboj/18.1.22 · 1999 · External reference
The retinoblastoma protein and cell cycle control
10.1016/0092-8674(95)90385-2 · 1995 · External reference
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumors
10.1073/pnas.87.7.2775 · 1990 · External reference
Expression and amplification of cyclin genes in human breast cancer
1993 · External reference
Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction
1994 · External reference
The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
10.1126/science.2537532 · 1989 · External reference
Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines
1997 · External reference
Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas
1981 · External reference
Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue
10.1128/iai.66.9.4222-4228.1998 · 1998 · External reference
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
10.1016/0092-8674(88)90559-4 · 1988 · External reference
D-type cyclin-dependent kinase activity in mammalian cells
10.1128/mcb.14.3.2066 · 1994 · External reference
Identification of G(1) kinase activity for cdk6, a novel cyclin D partner
10.1128/mcb.14.3.2077 · 1994 · External reference
Unresolved reference
1992 · External reference
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
10.1038/ng0994-22 · 1994 · External reference
Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
1994 · External reference
Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia
10.1182/blood.v91.3.1016 · 1998 · External reference
Mutations of the INK4a locus in squamous cell carcinomas of human skin
10.1006/bbrc.1997.6217 · 1997 · External reference
Methylation-specific PCR
10.1073/pnas.93.18.9821 · 1996 · External reference
Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
10.1038/sj.onc.1202244 · 1998 · External reference
Rapid nuclear translocation and increased activity of cyclin-dependent kinase 6 after T cell activation
10.4049/jimmunol.158.11.5146 · 1997 · External reference
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
10.1038/sj.onc.1201570 · 1998 · External reference
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
10.1038/26155 · 1998 · External reference
Association Of Cdkn2a/P16(Ink4a) with human head and neck keratinocyte replicative senescence — relationship of dysfunction to immortality and neoplasia
1996 · External reference
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
10.1016/0092-8674(95)90214-7 · 1995 · External reference
A novel p16INK4A transcript
1995 · External reference
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
10.1016/s1097-2765(00)80351-2 · 1999 · External reference
Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer
1996 · External reference
Flavopiridol
10.1023/a:1006353008903 · 1999 · External reference
