Research graph
References from Regulation of lifespan by histone deacetylase. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurosecretory control of aging in Caenorhabditis elegans
10.1073/pnas.96.13.7394 · 1999 · External reference
Unresolved reference
External reference
Genomewide studies of histone deacetylase function in yeast
10.1073/pnas.250477697 · 2000 · External reference
RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway
10.1016/0168-9525(91)90018-l · 1991 · External reference
Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis
10.1056/nejm198406213102503 · 1984 · External reference
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast
10.1101/gad.11.2.255 · 1997 · External reference
Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene
10.1093/hmg/8.12.2317 · 1999 · External reference
Extension of lifespan by loss of chico, a Drosophila insulin receptor substrate protein
10.1126/science.1057991 · 2001 · External reference
Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial
10.1182/blood.v85.1.43.bloodjournal85143 · 1995 · External reference
Elimination of replication block protein Fob1 extends the lifespan of yeast mother cells
10.1016/s1097-2765(00)80472-4 · 1999 · External reference
Sound silencing: the Sir2 protein and cellular senescence
2001 · External reference
Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
10.1182/blood.v84.1.339.339 · 1994 · External reference
A mutation in the age1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
10.1093/genetics/118.1.75 · 1998 · External reference
Nuclear pore complexes in the organization of silent telomeric chromatin
10.1038/47528 · 2000 · External reference
Position effect at S. cerevisiae: reversible inhibition of PolII transcription
10.1016/0092-8674(90)90141-z · 1990 · External reference
The human histone deacetylase family
10.1006/excr.2000.5080 · 2001 · External reference
10.1074/jbc.m109861200
10.1074/jbc.m109861200 · External reference
Genetics pathways that regulate aging in model organisms
10.1038/35041700 · 2000 · External reference
Blooms syndrome genes suppresses premature aging caused by Sgs1 deficiency in yeast
10.1046/j.1365-2443.1999.00288.x · 1999 · External reference
Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss
10.1093/genetics/145.3.605 · 1997 · External reference
The transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
10.1038/35001622 · 2000 · External reference
Replication control and cellular lifespan
10.1016/0531-5565(89)90049-1 · 1989 · External reference
Metabolic control and aging
10.1016/s0168-9525(00)02119-3 · 2000 · External reference
Mol. Biol. Aging
10.1016/s0092-8674(00)80567-x · 1999 · External reference
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
10.1101/gad.13.19.2570 · 1999 · External reference
10.1073/pnas.022631999
10.1073/pnas.022631999 · External reference
Isolation and characterization of mammalian HDAC10, a novel histone deacetylase
10.1074/jbc.m108931200 · 2002 · External reference
Gene redundancy and pharmacological gene therapy: implication for X-linked adrenoleukodystrophy
10.1038/3242 · 1998 · External reference
Daughter cells of S. cerevisiae from old mothers display reduced lifespan
10.1083/jcb.127.6.1985 · 1994 · External reference
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of lifespan in S. cerevisiae
10.1016/s0092-8674(00)80219-6 · 1997 · External reference
C. elegans mutant that lives twice as long as wild type
10.1038/366461a0 · 1993 · External reference
The origin and utility of histone deacetylase
10.1016/s0014-5793(97)01423-3 · 1997 · External reference
Functional significance of histone deacetylase diversity
10.1016/s0959-437x(00)00174-x · 2001 · External reference
Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae
10.1006/bbrc.1996.0240 · 1996 · External reference
Modulation of lifespan by histone deacetylase genes in Saccharomyces cerevisiae
10.1091/mbc.10.10.3125 · 1999 · External reference
daf2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
10.1126/science.277.5328.942 · 1997 · External reference
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
10.1093/genetics/152.1.179 · 1999 · External reference
Histone deacetylase as a therapeutic target
10.1016/s1043-2760(01)00438-6 · 2001 · External reference
Gene expression profile of aging and its retardation by caloric restriction
10.1126/science.285.5432.1390 · 1999 · External reference
Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
10.1126/science.289.5487.2126 · 2000 · External reference
Extended lifespan and stress resistance in the Drosophila mutant methuselah
10.1126/science.282.5390.943 · 1998 · External reference
Temperature, stress response and aging
10.1017/s0959259800004585 · 1996 · External reference
Negative control of p53 by Sir2α promotes cell survival under stress
10.1016/s0092-8674(01)00524-4 · 2001 · External reference
The isoenzymes of glutathione transferase
1985 · External reference
Histone deacetylase inhibitors as new cancer drugs
10.1097/00001622-200111000-00010 · 2001 · External reference
Control of muscle development by dueling HATs and HDACs
10.1016/s0959-437x(00)00224-0 · 2001 · External reference
Effects of phenylbutyrate on proliferation and apoptosis in human cancer cells in vitro and in vivo
1999 · External reference
Extension of lifespan with superoxide dismutase/catalase mimetics
10.1126/science.289.5484.1567 · 2000 · External reference
Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase2 nullizygous mice treated with superoxide dismutase-catalase mimetics
10.1523/jneurosci.21-21-08348.2001 · 2001 · External reference
Extension of lifespan by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
10.1126/science.8108730 · 1994 · External reference
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
10.1038/534 · 1998 · External reference
A short-term trial of butyrate to stimulate fetal-globin-disorders
10.1056/nejm199301143280202 · 1993 · External reference
Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity
10.1073/pnas.86.8.2761 · 1989 · External reference
Targeted neuronal gene expression and longevity in Drosophila
10.1016/s0531-5565(00)00117-0 · 2000 · External reference
Chromosomal localization links the SIN3–RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
10.1093/emboj/19.22.6131 · 2000 · External reference
Extended lifespan conferred by co-transporter gene mutations in Drosophila
10.1126/science.290.5499.2137 · 2000 · External reference
A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in F508-homozygout cystic fibrosis patients
10.1164/ajrccm.157.2.9706088 · 1998 · External reference
HDA1 and RPD3 are members of distinct yeast histone deacetylase complex that regulate silencing and transcription
10.1073/pnas.93.25.14503 · 1996 · External reference
Microarray analysis of replicative senescence
10.1016/s0960-9822(99)80420-5 · 1999 · External reference
Extrachromosomal rDNA circles—a cause of aging in yeast
10.1016/s0092-8674(00)80493-6 · 1997 · External reference
10.1038/47412
10.1038/47412 · External reference
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the lifespan of adult Drosophila melanogaster flies
10.1128/mcb.19.1.216 · 1999 · External reference
Chaperoning extended life
10.1038/36237 · 1997 · External reference
A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function
10.1126/science.1057987 · 2001 · External reference
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
10.1126/science.272.5260.408 · 1996 · External reference
Increased dosage of a sir2 gene extends lifespan in Caenorhabditis elegans
10.1038/35065638 · 2001 · External reference
p53 mutant mice that display early aging-associated phenotypes
10.1038/415045a · 2002 · External reference
hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase
10.1016/s0092-8674(01)00527-x · 2001 · External reference
Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells
1999 · External reference
Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster
10.1016/0047-6374(84)90118-0 · 1984 · External reference
Mutations in the clk1 gene of Caenorhabditis elegans affect developmental and behavioral timing
10.1093/genetics/139.3.1247 · 1995 · External reference
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster
10.1073/pnas.260496697 · 2000 · External reference
Cloning and characterization of a histone deacetylase HDAC9
10.1073/pnas.191375098 · 2001 · External reference