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References from Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Local targets link to admitted publications; unresolved targets remain external evidence.
Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication
10.1073/pnas.74.4.1348 · 1977 · External reference
Caloric restriction reduces fibre loss and mitochondrial abnormalities in aged rat muscle
10.1096/fasebj.11.7.9212081 · 1997 · External reference
Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA
10.1096/fasebj.10.2.8641567 · 1996 · External reference
Mitochondrial free radical generation: sites of production in states 4 and 3, organ specificity and relationship with aging rate
10.1023/a:1005427919188 · 1999 · External reference
The flux of free radical attack through mitochondrial DNA is related to aging rate
10.1007/bf03339859 · 2000 · External reference
Localization at complex I and mechanism of the higher free radical production of brain non-synaptic mitochondria in the short-lived rat than in the longevous pigeon
10.1023/a:1020592719405 · 1998 · External reference
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
10.1096/fasebj.14.2.312 · 2000 · External reference
A decrease of free radical production near critical sites as the main cause of maximum longevity in animals
10.1016/0305-0491(94)90103-1 · 1994 · External reference
Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds
10.3109/10715769409056584 · 1994 · External reference
10.1007/978-3-0348-7460-1_12
10.1007/978-3-0348-7460-1_12 · External reference
Oxidative decay of DNA
10.1074/jbc.272.32.19633 · 1997 · External reference
The free radical theory of aging matures
10.1152/physrev.1998.78.2.547 · 1998 · External reference
Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system
10.1016/0891-5849(94)00244-e · 1995 · External reference
Protein oxidation in aging, disease, and oxidative stress
10.1074/jbc.272.33.20313 · 1997 · External reference
The mitochondrial generation of hydrogen peroxide
10.1042/bj1340707 · 1973 · External reference
Role of mitochondrial DNA mutations in human aging: implications from the central nervous system and muscle
10.1002/ana.410430212 · 1998 · External reference
Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia
10.1073/pnas.92.14.6264 · 1995 · External reference
Reversal of age-related increase in brain protein oxidation, decrease in enzymatic activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone
10.1073/pnas.88.9.3633 · 1991 · External reference
Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage
10.1016/0047-6374(94)01561-y · 1995 · External reference
Unresolved reference
External reference
Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats
10.1016/s0891-5849(01)00576-7 · 2001 · External reference
The reductive hot spot hypothesis: an update
10.1006/abbi.1999.1509 · 2000 · External reference
Mice with homologous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide
10.1074/jbc.273.35.22528 · 1998 · External reference
Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fisher-344 rat brains
10.1016/s0306-4522(96)00607-0 · 1997 · External reference
Induction of β-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells
10.1128/mcb.9.2.851 · 1989 · External reference
10.1073/pnas.87.12.4533
10.1073/pnas.87.12.4533 · External reference
Lipid hydroperoxide generation, turnover, and effector action in biological systems
10.1016/s0022-2275(20)32182-9 · 1998 · External reference
10.1007/978-3-0348-7337-6_16
10.1007/978-3-0348-7337-6_16 · External reference
Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
10.1096/fj.00-0764fje · 2001 · External reference
10.1023/a:1010603206190
10.1023/a:1010603206190 · External reference
Ubiquitous expression of CuZn superoxide dismutase does not extend life span in mice
2000 · External reference
The biological clock: the mitochondria?
10.1111/j.1532-5415.1972.tb00787.x · 1972 · External reference
ADP-regulation of mitochondrial free radical production is different with complex I- or II-linked substrates: implications for the exercise paradox and brain hypermetabolism
10.1023/a:1022458010266 · 1997 · External reference
Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon
10.1016/s0047-6374(97)00076-6 · 1997 · External reference
H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved
10.1016/s0047-6374(98)00035-9 · 1998 · External reference
8-Oxodeoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging
10.1007/bf03339803 · 1999 · External reference
Localization of the site of oxygen radical generation inside the complex I of heart and non-synaptic brain mammalian mitochondria
10.1023/a:1005626712319 · 2000 · External reference
Effect of aging on mitochondrial and nuclear DNA oxidative damage in the heart and brain throughout the life-span of the rat
2001 · External reference
8-Hydroxyguanine levels in nuclear DNA and its repair in rat organs associated with age
10.1093/gerona/51a.5.b303 · 1996 · External reference
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
10.1074/jbc.272.26.16644 · 1997 · External reference
Mice lacking copper/zinc superoxide dismutase show no increased sensitivity to hyperoxia
1997 · External reference
Effect of voluntary exercise on longevity in rats
10.1152/jappl.1985.59.3.826 · 1985 · External reference
Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1
10.1006/nbdi.2000.0299 · 2000 · External reference
Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging
10.1016/s0921-8734(96)90010-7 · 1996 · External reference
Age-related increases in plasma phosphatidylcholine hydroperoxide concentrations in control subjects and patients with hyperlipidaemia
10.1093/clinchem/46.6.822 · 2000 · External reference
8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer’s disease
10.1016/s0197-4580(96)00165-0 · 1996 · External reference
Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging
10.1111/j.1749-6632.1998.tb09900.x · 1998 · External reference
Comparison of mitochondrial pro-oxidant generation and antioxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential
10.1016/0047-6374(93)90132-b · 1993 · External reference
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
10.1016/0891-5849(93)90165-q · 1993 · External reference
Exercise intensity and longevity in men: the Harvard alumni health study
10.1001/jama.273.15.1179 · 1995 · External reference
Caloric restriction attenuates dityrosine crosslinking of cardiac and skeletal muscle proteins in aging mice
10.1006/abbi.1997.0297 · 1997 · External reference
Mitochondrial DNA 4977 bp deletion and OH8dG levels correlated in the brain of aged subjects but not Alzheimer’s disease patients
10.1096/fasebj.13.9.1083 · 1999 · External reference
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
10.1038/ng1295-376 · 1995 · External reference
Simultaneous induction of superoxide dismutase, glutathione reductase, GSH and ascorbate in liver and kidney correlates with survival throughout the life span
10.1016/0891-5849(93)90052-v · 1993 · External reference
Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart
10.1016/s0303-7207(00)00302-6 · 2000 · External reference
Oxidative damage to mitochondrial DNA shows age-dependent increases in human brain
10.1002/ana.410340416 · 1993 · External reference
Age-dependent increases in oxidative damage to DNA, lipids and proteins in human skeletal muscle
10.1016/s0891-5849(98)00208-1 · 1999 · External reference
Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age
10.1093/nar/25.5.974 · 1997 · External reference
Mouse models of mitochondrial disease, oxidative stress, and senescence
10.1016/s0921-8777(99)00031-2 · 1999 · External reference
Mitochondrial disease in superoxide dismutase 2 mutant mice
10.1073/pnas.96.3.846 · 1999 · External reference
Proteolysis, caloric restriction and aging
10.1016/s0047-6374(01)00219-6 · 2001 · External reference
Aging-dependent large accumulation of point mutations in the human DNA control region for replication
10.1126/science.286.5440.774 · 1999 · External reference
Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells
10.1016/0047-6374(95)01687-2 · 1996 · External reference
Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia
10.1096/fasebj.13.13.1733 · 1999 · External reference
Presence of a DNA, 4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging
10.1007/bf03339606 · 1996 · External reference
10.1007/978-3-662-12509-0_11
10.1007/978-3-662-12509-0_11 · External reference
Unresolved reference
External reference
Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (SOD1) increases susceptibility to noise-induced hearing loss
10.1159/000013847 · 1999 · External reference
Age-related changes in oxidized proteins
10.1016/s0021-9258(18)45598-6 · 1987 · External reference
10.1016/b978-012636670-9/50025-8
10.1016/b978-012636670-9/50025-8 · External reference
Mitochondrial DNA mutations associated with aging and degenerative diseases
10.1016/0531-5565(94)00057-a · 1995 · External reference
Mitochondrial gene mutation in cell death and aging
10.1023/a:1005479920097 · 1999 · External reference
10.1080/10715760210165
10.1080/10715760210165 · External reference
Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage
10.1016/0027-5107(94)90012-4 · 1994 · External reference
The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
10.1007/s003600050131 · 1998 · External reference
Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle
10.1016/s0891-5849(01)00517-2 · 2001 · External reference
The mammalian Mre11–Rad50–nbs1 protein complex: integration of functions in the cellular damage response
10.1086/302391 · 1999 · External reference
Life span in birds and the ageing theory of absolute metabolic scope
10.1016/0300-9629(93)90260-b · 1993 · External reference
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
10.1038/ng0596-43 · 1996 · External reference
Normal oxidative damage to mitochondrial and nuclear DNA is extensive
10.1073/pnas.85.17.6465 · 1988 · External reference
Changes of 8-hydroxydeoxyguanosine levels in rat organ DNA during the aging process
1992 · External reference
Mitochondria, aging and longevity—a new perspective
10.1016/s0014-5793(01)02199-8 · 2001 · External reference
Energy expenditure of rats subjected to long-term food restriction
10.1080/713671773 · 2001 · External reference
Mitochondria, oxidative stress and aging
10.1080/10715760000300201 · 2000 · External reference
Mitochondrial oxidative stress plays a key role in aging and apoptosis
10.1080/152165400410281 · 2000 · External reference
Mice lacking cytosolic superoxide dismutase display a distinctive motor axonopathy
10.1212/wnl.53.6.1239 · 1999 · External reference
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer’s disease
10.1073/pnas.88.23.10540 · 1991 · External reference
Relationship between antioxidant defenses and longevity in different mammalian species
10.1016/0047-6374(90)90040-m · 1990 · External reference
Hydrogen peroxide production by liver mitochondria in different species
10.1016/0047-6374(90)90039-i · 1990 · External reference
Effect of age on DNA oxidative damage in different tissues of C57BL/6 mice
10.1016/0047-6374(94)91595-4 · 1994 · External reference
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction
10.1016/0047-6374(94)90104-x · 1994 · External reference
Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)
10.1016/0047-6374(94)01578-a · 1995 · External reference
Protein oxidation and aging
10.1126/science.1355616 · 1992 · External reference
Protein oxidation and proteolysis during aging and oxidative stress
10.1016/0003-9861(89)90402-5 · 1989 · External reference
Unresolved reference
External reference
Age-related changes in oxidative damage to lipids and DNA in rat skin
10.1016/s0047-6374(00)00257-8 · 2001 · External reference
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NAD-ubiquinone-reductase preparation
10.1042/bj1800129 · 1979 · External reference
Superoxide dismutase correlation with life-span and specific metabolic rate in primate species
10.1073/pnas.77.5.2777 · 1980 · External reference
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
10.1042/bj1910421 · 1980 · External reference
Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity
10.1165/ajrcmb.19.1.3066 · 1998 · External reference
The rate of mitochondrial mutagenesis is faster in mice than in humans
10.1016/s0027-5107(97)00091-2 · 1997 · External reference
Microfile profiling of gene expression in aging and its alteration by caloric restriction in mice
10.1093/jn/131.3.918s · 2001 · External reference
10.1002/cphy.cp110123
10.1002/cphy.cp110123 · External reference
