Research graph
References from Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Investigation of the role of G1/S cell cycle mediators in cellular senescence
10.1006/excr.1993.1306 · 1993 · External reference
Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR1 gene, in T cell subsets from aging humans
10.1023/a:1027363525408 · 1997 · External reference
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
10.1038/ng0397-236 · 1997 · External reference
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
10.1126/science.277.5333.1805 · 1997 · External reference
The International ABCR Screening Consortium 2000. Further evidence for an association of ABCR alleles with age-related macular degeneration
10.1086/303018 · 2000 · External reference
Unresolved reference
External reference
Expression of P-glycoprotein in the chicken
10.1016/s1095-6433(01)00389-0 · 2000 · External reference
Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging
10.1093/gerona/52a.3.b137 · 1997 · External reference
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
10.1038/11914 · 1999 · External reference
Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
1996 · External reference
Cardiovascular determinants of carotid artery disease: the Rotterdam Eldery Study
10.1161/01.hyp.19.6.717 · 1992 · External reference
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
10.1038/11905 · 1999 · External reference
Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination
10.1093/geronj/48.6.b231 · 1993 · External reference
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
10.1016/0092-8674(91)90141-k · 1991 · External reference
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
10.1172/jci10727 · 2000 · External reference
Multidrug resistance gene (P-glycoprotein) is expressed by endothelial cells at blood brain barrier sites
10.1073/pnas.86.2.695 · 1989 · External reference
Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt’s disease gene ABCR
10.1093/hmg/7.3.355 · 1998 · External reference
Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration
10.1016/s0161-6420(99)90449-9 · 1999 · External reference
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-γ in normal human T lymphocytes
10.1182/blood.v88.5.1747.1747 · 1996 · External reference
ABCR gene and age-related macular degeneration
10.1126/science.279.5354.1107a · 1998 · External reference
The human ATP-binding cassette transporter genes: from the bench to the bedside
10.2174/1566524013364194 · 2001 · External reference
Clinical relevance of the MDR-1 gene and its gene product, P-glycoprotein, for cancer chemotherapy: a meta-analysis
1993 · External reference
Impact of viral oncogenesis on responses to anti-cancer drugs and irradiation
2000 · External reference
mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice
10.4049/jimmunol.163.5.2621 · 1999 · External reference
Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset
10.4049/jimmunol.164.12.6105 · 2000 · External reference
Aged T cells are hyporesponsive to co-stimulation mediated by CD28
10.4049/jimmunol.152.8.3740 · 1994 · External reference
Differences in the expression profiles of CD45RB, P-gp-1, and 3G11 membrane antigens in the patterns of lymphokine secretion by splenic CD4+ T cells from young and old mice
10.4049/jimmunol.145.5.1295 · 1990 · External reference
The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression
10.4049/jimmunol.151.2.575 · 1993 · External reference
Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency
10.1002/eji.1830220408 · 1992 · External reference
Expression of a multidrug resistance gene in human tumors and tissues
10.1073/pnas.84.1.265 · 1987 · External reference
Molecular genetic analysis of ABCR gene in Japanese dry form age-related macular degeneration
10.1016/s0021-5155(00)00150-7 · 2000 · External reference
Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily
10.1002/(sici)1097-0061(199701)13:1<43::aid-yea56>3.0.co;2-j · 1997 · External reference
Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia
10.1007/s004390050817 · 1998 · External reference
Biochemistry of multidrug resistance mediated by the multidrug transporter
10.1146/annurev.bi.62.070193.002125 · 1993 · External reference
Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues
10.1053/meta.2000.17822 · 2000 · External reference
P-glycoprotein expression and regulation. Age-related changes and potential effects on drug therapy
10.2165/00002512-199507010-00003 · 1995 · External reference
P-glycoprotein in cells of the human immune system
1996 · External reference
P-glycoprotein (MDR1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection
10.1007/bf00920237 · 1993 · External reference
Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in CD8+ T cells: A role in cytotoxic effector function
10.1007/bf00918857 · 1992 · External reference
Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration
10.1001/archopht.119.5.745 · 2001 · External reference
Telomeres and telomerase in aging and cancer
10.1016/0959-437x(95)80016-6 · 1995 · External reference
The limited in vitro lifetime of human diploid cell strains
10.1016/0014-4827(65)90211-9 · 1965 · External reference
How and why we age
10.1016/s0531-5565(98)00023-0 · 1998 · External reference
The future of ageing
10.1038/35041709 · 2000 · External reference
P-glycoprotein expression and function in circulating blood cells from normal volunteers
10.1038/bjc.1993.83 · 1993 · External reference
ABC transporters: from microorganisms to man
10.1146/annurev.cb.08.110192.000435 · 1992 · External reference
The ABC of channel regulation
10.1016/0092-8674(95)90465-4 · 1995 · External reference
Is the multidrug transporter a flippase
10.1016/0968-0004(92)90419-a · 1992 · External reference
The cystic fibrosis transmembrane conductance regulator as a marker of human pancreatic duct development
10.1016/s0016-5085(97)70187-2 · 1997 · External reference
Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
10.2337/diabetes.45.6.825 · 1996 · External reference
Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese
10.2337/diabetes.45.2.267 · 1996 · External reference
Memory and anergy: challenges to traditional models of T lymphocyte differentiation
10.1096/fasebj.6.7.1563595 · 1992 · External reference
(Sulfonylurea receptor gene polymorphism is associated with non-insulin dependent diabetes mellitus in Chinese population)
1998 · External reference
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cells
10.1016/0005-2736(76)90160-7 · 1976 · External reference
Positive correlation between mammalian life span and cellular resistance to stress
10.1016/s0891-5849(98)00323-2 · 1999 · External reference
Evolution of ageing
10.1016/s0047-6374(01)00419-5 · 2002 · External reference
Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli
10.1016/0008-8749(92)90083-2 · 1992 · External reference
Prevalence of age-related maculopathy: The Beaver Dam Eye Study
10.1016/s0161-6420(92)31871-8 · 1992 · External reference
P-glycoprotein expression and function in circulating blood cells from normal volunteers
10.1182/blood.v83.9.2451.2451 · 1994 · External reference
ATP binding cassette transporter retina genotypes and age related macular degeneration: an analysis on exudative non-familial Japanese patients
10.1136/bjo.83.5.613 · 1999 · External reference
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
10.1038/36285 · 1997 · External reference
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
10.1172/jci8119 · 1999 · External reference
Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A
10.1002/eji.1830190604 · 1989 · External reference
Genotype/phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease
10.1086/302251 · 1999 · External reference
Cellular cholesterol transport and efflux in fibroblasts are abnormal in subjects with familial HDL deficiency
10.1161/01.atv.19.1.159 · 1999 · External reference
Genetic analysis of aging: role of oxidative damage and environmental stress
10.1038/ng0596-25 · 1996 · External reference
Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR
10.1038/ng0198-11 · 1998 · External reference
Delayed dark-adaptation and lipofuscin accumulation in abcr+/− mice: implications for involvement of ABCR in age-related macular degeneration
2001 · External reference
Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain
10.1002/(sici)1097-4695(19990605)39:3<383::aid-neu5>3.0.co;2-4 · 1999 · External reference
Unresolved reference
External reference
Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population
10.1093/gerona/56.4.b180 · 2001 · External reference
Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice
10.1016/s0047-6374(97)01893-9 · 1997 · External reference
CD4 memory T cell levels predict life span in genetically heterogeneous mice
10.1096/fasebj.11.10.9271362 · 1997 · External reference
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
10.1016/s0140-6736(96)07495-8 · 1997 · External reference
Age-related changes in lymphokine production related to a decreased number of CD45BhiCD4+ T cells
10.1002/eji.1830210206 · 1991 · External reference
Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified TAC-positive T cells
10.1016/0047-6374(86)90089-8 · 1986 · External reference
Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews
10.1093/hmg/5.11.1813 · 1996 · External reference
Prevention of drug access to bacterial targets: permeability barriers and active efflux
10.1126/science.8153625 · 1994 · External reference
Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and ABC1-deficient mice
10.1038/72869 · 2000 · External reference
Evidence for the recessive nature of cellular immortality
10.1126/science.6879195 · 1983 · External reference
Multidrug transporter P-glycoprotein 170 as a differentiation antigen on normal human lymphocytes and thymocytes
10.1002/ajh.2830490411 · 1995 · External reference
Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes
1996 · External reference
Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred
10.1073/pnas.96.22.12685 · 1999 · External reference
A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration
10.1086/303090 · 2000 · External reference
Spectrum of ABCR gene mutations in autosomal recessive macular dystrophies
10.1038/sj.ejhg.5200221 · 1998 · External reference
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
10.1038/11921 · 1999 · External reference
The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial
10.1016/s0042-6989(99)00037-1 · 1999 · External reference
Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration
10.1093/hmg/10.23.2671 · 2001 · External reference
Human ABCA1 BAC transgenic mice show increased HDL-C and Apo A1 dependent efflux stimulated by an internal promotor containing liver X receptor response elements in intron 1
10.1074/jbc.m102503200 · 2001 · External reference
Effect of aggressive versus conventional lipid lowering on atherosclerois progression in familial hypocholesterolaemia (ASAP): a prospective, randomised, double-blind trial
10.1016/s0140-6736(00)04053-8 · 2001 · External reference
Age-related macular degeneration in grandparents of patients with Stargardt disease: genetic study
10.1016/s0002-9394(99)00145-2 · 1999 · External reference
Failure to phosphorylate the retinoblastoma product in senescent human fibroblasts
10.1126/science.2166342 · 1990 · External reference
Linkage studies in NIDDM with markers near the sulfonurea receptor gene
10.1007/bf00400610 · 1995 · External reference
Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration Nat
1998 · External reference
Stargardt’s ABCR is localized to the disc membrane of retinal rod outer segments
10.1038/ng0997-15 · 1997 · External reference
Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease
10.1074/jbc.274.12.8269 · 1999 · External reference
Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
10.1126/science.7716548 · 1995 · External reference
Different sulfonylurea and ATP sensitivity characterizes the juvenile and the adult form of KATP channel complex of rat skeletal muscle
10.1016/s0014-2999(96)00965-x · 1997 · External reference
P-glycoprotein expression in mouse brain increases with maturation
10.1159/000047185 · 2002 · External reference
A universal pattern of mortality decline in the G7 countries
10.1038/35015561 · 2000 · External reference
Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins
10.1016/s0005-2736(99)00157-1 · 1999 · External reference
Differential age-change in the numbers of CD4+ CA45RA+ and CD4+CD29+ T cell subsets in human peripheral blood
10.1016/0047-6374(92)90016-7 · 1992 · External reference
Influence of age on the signal transduction of T cells in mice
10.1093/intimm/5.9.1177 · 1993 · External reference
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
10.1172/jci200112517 · 2001 · External reference
Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study
10.1016/s0140-6736(02)07277-x · 2002 · External reference
MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
10.1016/s0092-8674(00)81370-7 · 1996 · External reference
Overexpression of P-glycoprotein in rat hepatocellular carcinomas induced with N-nitrosomorpholine
10.1093/carcin/11.1.169 · 1990 · External reference
Common and rare ABCA1 variants affecting plasma HDL cholesterol
10.1161/01.atv.20.8.1983 · 2000 · External reference
An analysis of allelic variation in the ABCA4 gene
2001 · External reference
Impaired lymphocyte function in aged humans
10.1172/jci107565 · 1974 · External reference
Insights into the function of Rim protein in photoreceptors and etiology of Stargardt’s disease from the phenotype in abcr knockout mice
10.1016/s0092-8674(00)80602-9 · 1999 · External reference
Age-related alterations in the activation and expression of phosphotyrosine kinase and protein kinase C (PKC) among human B cells
10.1016/0047-6374(93)90033-n · 1993 · External reference
Pleiotropy, natural selection and the evolution of senescence
10.2307/2406060 · 1957 · External reference
Increased function of P-glycoprotein in T lymphocytes subsets of aging mice
10.4049/jimmunol.150.4.1296 · 1993 · External reference
Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein
10.1016/s0047-6374(98)00147-x · 1999 · External reference
Reciprocal expression of P-glycoprotein and TAP1 accompanied by higher expression of MHC class I antigens in T cells of old mice
10.1093/gerona/51a.1.b76 · 1996 · External reference
Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle
10.1002/cne.903140206 · 1991 · External reference
The ABCs of cholesterol efflux
10.1038/11878 · 1999 · External reference
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and ageing
10.1038/sj.onc.1201178 · 1997 · External reference
