Research graph
References from The search for type 2 diabetes genes. Local targets link to admitted publications; unresolved targets remain external evidence.
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
10.1038/79839 · 2000 · External reference
10.2337/diacare.23.3.381
10.2337/diacare.23.3.381 · External reference
The rising global burden of diabetes and its complications: estimates and projections to the year 2010
10.1002/(sici)1096-9136(199712)14:5+<s7::aid-dia522>3.3.co;2-i · 1997 · External reference
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
10.1172/jci10665 · 2000 · External reference
Diabetes in identical twins: a study of 200 pair
10.1007/bf00262007 · 1981 · External reference
Mitochondrial diabetes, DIDMOAD and other inherited diabetes syndromes
10.1053/beem.2001.0149 · 2001 · External reference
Dominant negative mutations in human PPAR gamma associated with severe insulin resistance, diabetes mellitus and hypertension
10.1038/47254 · 1999 · External reference
Mutations in hepatocyte nuclear factor 1 beta are not a common cause of maturity-onset diabetes of the young in the UK
10.2337/diabetes.47.7.1152 · 1998 · External reference
Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes
10.2337/diabetes.50.1.204 · 2001 · External reference
Evidence of a novel type 2 diabetes locus 50cM centromeric to NIDDM2 on chromosome 12q
10.2337/diabetes.48.11.2246 · 1999 · External reference
Gene for non-insulin dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
10.1073/pnas.88.4.1484 · 1991 · External reference
Mutations in the HNF1-beta gene are associated with familial hypoplastic glomerulocystic kidney disease
10.1086/316945 · 2001 · External reference
10.1046/j.1523-1755.2000.057003898.x
10.1046/j.1523-1755.2000.057003898.x · External reference
Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy
10.2337/diabetes.46.5.882 · 1997 · External reference
Insulin promoter factor 1 gene (IPF1) is not a major cause of maturity-onset diabetes of the young in French Caucasians
10.2337/diabetes.47.5.843 · 1998 · External reference
Beacon: a novel gene involved in the regulation of energy balance
10.2337/diabetes.49.11.1766 · 2000 · External reference
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican–Americans
10.1038/6002 · 1999 · External reference
Parameters for reliable results in genetic association studies in common disease
10.1038/ng825 · 2002 · External reference
Intermediate expansions of a GAA repeat in the frataxin gene are not associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians
10.2337/diabetes.48.4.914 · 1999 · External reference
10.1086/302950
10.1086/302950 · External reference
A genome-wide search for type II diabetes susceptibility genes in Utah Caucasians
10.2337/diabetes.48.5.1175 · 1999 · External reference
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the UK
10.1086/323315 · 2001 · External reference
Beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors
10.2337/diabetes.50.2007.s94 · 2001 · External reference
No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in UK Caucasians
10.1210/jc.85.2.853 · 2000 · External reference
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
10.1038/356162a0 · 1992 · External reference
SNP43 of CAPN10 and the risk of type 2 Diabetes in African–Americans: the Atherosclerosis Risk in Communities Study
10.2337/diabetes.51.1.231 · 2002 · External reference
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
10.1038/ng0196-38 · 1996 · External reference
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
10.1073/pnas.96.5.2198 · 1999 · External reference
Unresolved reference
External reference
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
10.1172/jci7469 · 1999 · External reference
A genome-wide search for human non-insulin dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
10.1038/ng0696-161 · 1996 · External reference
10.1086/302061
10.1086/302061 · External reference
Mutations in the coding region of the insulin promoter factor 1 gene are not a common cause of maturity-onset diabetes of the young in Japanese subjects
10.2337/diabetes.47.5.845 · 1998 · External reference
Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects
10.1111/j.1464-5491.1993.tb00150.x · 1993 · External reference
Linkage of type 2 diabetes to the glucokinase gene
10.1016/0140-6736(92)91958-b · 1992 · External reference
A comprehensive review of genetic association studies
10.1097/00125817-200203000-00002 · 2002 · External reference
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
10.1038/79876 · 2000 · External reference
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease
10.1038/35079107 · 2001 · External reference
Analysis of parent–offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles
10.2337/diabetes.49.1.126 · 2000 · External reference
Replication validity of genetic association studies
10.1038/ng749 · 2001 · External reference
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA
10.1056/nejm199404073301403 · 1994 · External reference
Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators
10.1016/s0140-6736(00)82009-7 · 2000 · External reference
Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2
10.2337/diabetes.49.12.2212 · 2000 · External reference
Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis
10.1002/dmr.5610060101 · 1990 · External reference
Unresolved reference
External reference
Genome-wide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study
10.1086/338629 · 2002 · External reference
Missense mutations in the insulin promoter factor 1 (IPF-1) gene predispose to type 2 diabetes
10.1172/jci7449 · 1999 · External reference
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
10.1038/ng0996-90 · 1996 · External reference
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
10.1038/15500 · 1999 · External reference
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in UK populations
10.2337/diabetes.51.4.1287 · 2002 · External reference
Rare variants identified in the HNF-4α b-cell specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and type 2 diabetes
10.1007/s00125-002-0913-7 · 2002 · External reference
The role of the HNF4alpha enhancer in type 2 diabetes
10.1016/s1096-7192(02)00027-6 · 2002 · External reference
Diabetes trends in the US: 1990–1998
10.2337/diacare.23.9.1278 · 2000 · External reference
Unresolved reference
External reference
Concordance for type II (non-insulin dependent) diabetes mellitus in male twins
10.1007/bf00275741 · 1987 · External reference
Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1 beta gene associated with diabetes and renal dysfunction
10.2337/diabetes.47.8.1354 · 1998 · External reference
A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease
10.1038/35079114 · 2001 · External reference
Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization
10.1053/beem.2001.0148 · 2001 · External reference
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23
10.1038/ng0498-369 · 1998 · External reference
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
10.1126/science.1065573 · 2001 · External reference
Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor 1 alpha gene mutations: evidence for pharmacogenetics in diabetes
10.1046/j.1464-5491.2000.00305.x · 2000 · External reference
A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
10.2337/diabetes.50.3.681 · 2001 · External reference
A common mitochondrial variant is associated with insulin resistance in adult life
10.1007/s001250050866 · 1998 · External reference
Mapping genes in diabetes. Genetic epidemiological perspective
10.2337/diabetes.39.11.1315 · 1990 · External reference
K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels
10.2337/diabetes.51.3.875 · 2002 · External reference
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
10.1038/72807 · 2000 · External reference
Novel susceptibility gene for late onset NIDDM is localised to human chromosome 12q
10.2337/diabetes.47.11.1793 · 1998 · External reference
Hyperexcitability to sulphonylurea in MODY3
10.1007/s001250050956 · 1998 · External reference
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
10.1038/ng1097-138 · 1997 · External reference
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
10.1038/ng0197-106 · 1997 · External reference
Mild familial diabetes with dominant inheritance
1974 · External reference
10.1038/35057149
10.1038/35057149 · External reference
Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy
10.1093/hmg/5.11.1809 · 1996 · External reference
HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community
10.1073/pnas.062059799 · 2002 · External reference
Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association
10.1086/324646 · 2001 · External reference
A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
10.1038/ng0495-418 · 1995 · External reference
Genome-wide search for type 2 diabetes-susceptibility genes in French white: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
10.1086/316887 · 2000 · External reference
A genome-wide scan for loci predisposing to type 2 diabetes in a UK population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q
10.1086/323249 · 2001 · External reference
Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians
10.1007/s001250051688 · 2001 · External reference
Mutations in the hepatocyte nuclear factor 4 alpha gene in maturity-onset diabetes of the young (MODY1)
10.1038/384458a0 · 1996 · External reference
Mutations in the hepatic nuclear factor 1 alpha gene in maturity-onset diabetes of the young (MODY3)
10.1038/384455a0 · 1996 · External reference
The prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesian and Indian) population of Fiji—a rural urban comparison
10.1093/oxfordjournals.aje.a113678 · 1983 · External reference
Linkage analysis and molecular scanning of glucokinase gene in NIDDM families
10.2337/diabetes.42.9.1238 · 1993 · External reference
