Research graph
References from Mammalian longevity under the protection of PARP-1’s multi-facets. Local targets link to admitted publications; unresolved targets remain external evidence.
CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians
10.1093/ageing/26.2.147 · 1997 · External reference
Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients
10.1159/000055354 · 2001 · External reference
Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents
10.1016/0921-8777(89)90012-8 · 1989 · External reference
PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
10.1074/jbc.274.25.17860 · 1999 · External reference
Mutant debrisoquine hydroxylation genes in Parkinson’s disease
10.1016/0140-6736(92)90537-d · 1992 · External reference
Fluorescence in situ mapping of the human nuclear NAD+ ADP-ribosyltransferase gene (ADPRT) and two secondary sites to human chromosomal bands 1q42, 13q34, and 14q24
10.1159/000133400 · 1992 · External reference
DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53
10.1128/mcb.20.18.6695-6703.2000 · 2000 · External reference
Comparative characterisation of poly(ADP-ribose) polymerase-1 from two mammalian species with different life span
10.1016/s0531-5565(00)00134-0 · 2000 · External reference
Poly(ADP-ribose) in the cellular response to DNA damage
10.2307/3576299 · 1985 · External reference
Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
1981 · External reference
A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x · 2001 · External reference
Poly(ADP-ribosyl)ation, genomic instability, and longevity
10.1111/j.1749-6632.2000.tb06641.x · 2000 · External reference
Physiology and pathophysiology of poly(ADP-ribosyl)ation
10.1002/bies.1115 · 2001 · External reference
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel molecular ‘nick-sensor’ in vitro
10.1093/nar/24.22.4387 · 1996 · External reference
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase
10.1073/pnas.84.23.8370 · 1987 · External reference
Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles
10.1074/jbc.m007635200 · 2000 · External reference
New polymorphisms in the human poly(ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity
10.1007/s001090050488 · 2000 · External reference
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
10.1038/12680 · 1999 · External reference
Involvement of poly(ADP-ribose) polymerase in base-excision repair
10.1016/s0300-9084(99)80040-6 · 1999 · External reference
Base-excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1
10.1021/bi0003442 · 2000 · External reference
DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems
10.1007/s004390050364 · 1997 · External reference
Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
10.1038/sj.ejhg.5200222 · 1998 · External reference
Premature ageing in mice deficient in DNA repair and transcription
10.1126/science.1070174 · 2002 · External reference
Is human ageing still mysterious enough to be left only to scientists?
10.1002/bies.10113 · 2002 · External reference
Unresolved reference
External reference
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
10.1073/pnas.94.14.7303 · 1997 · External reference
Association between prostate cancer in black Americans and an allele of the PADPRP pseudogene locus on chromosome 13
1996 · External reference
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
10.1038/nm1097-1089 · 1997 · External reference
Dinucleotide repeat polymorphism at the human poly(ADP-ribose) polymerase gene (PPOL)
10.1093/nar/20.5.1166 · 1992 · External reference
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
10.1038/ng0595-111 · 1995 · External reference
Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
10.1073/pnas.89.24.11759 · 1992 · External reference
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
10.1073/pnas.96.24.13978 · 1999 · External reference
Free radical theory of ageing: history
1992 · External reference
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
10.1073/pnas.71.6.2169 · 1974 · External reference
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
10.1074/jbc.270.19.11176 · 1995 · External reference
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41–q42 and expression of an active human enzyme in Escherichia coli
10.1073/pnas.86.10.3514 · 1989 · External reference
Genetic factors in individual responses to environmental exposures
10.1097/00043764-199501000-00006 · 1995 · External reference
HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity
10.1093/hmg/7.2.187 · 1998 · External reference
A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues
10.1006/geno.1999.5799 · 1999 · External reference
Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of ageing
10.1126/science.2392681 · 1990 · External reference
Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans
10.1016/s0531-5565(01)00144-9 · 2001 · External reference
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression
10.1074/jbc.m105968200 · 2001 · External reference
Positive correlation between mammalian life span and cellular resistance to stress
10.1016/s0891-5849(98)00323-2 · 1999 · External reference
Apolipoprotien E and B polymorphisms-longevity factors assessed in nonagenarians
10.1016/0021-9150(94)90011-6 · 1994 · External reference
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase
10.1083/jcb.146.5.917 · 1999 · External reference
Evolution of ageing
10.1016/s0047-6374(01)00419-5 · 2002 · External reference
Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells
10.1016/s0021-9258(17)30567-7 · 1990 · External reference
Trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N(-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replication
10.1128/mcb.15.6.3154 · 1995 · External reference
Ageing and resistance to oxidative damage in Caenorhabditis elegans
10.1073/pnas.90.19.8905 · 1993 · External reference
Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population
10.1038/sj.gene.6363823 · 2002 · External reference
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
10.1038/sj.gene.6363827 · 2002 · External reference
Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families
10.1002/(sici)1096-8628(19960726)67:4<361::aid-ajmg8>3.0.co;2-p · 1996 · External reference
A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer
1993 · External reference
Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14
10.1074/jbc.m009756200 · 2001 · External reference
TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
10.1006/bbrc.2001.5987 · 2001 · External reference
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
10.1128/mcb.18.6.3563 · 1998 · External reference
Modification of brain ageing and neurodegenerative disorders by genes, diet and behavior
10.1152/physrev.00004.2002 · 2002 · External reference
Animal models of oxidative stress, ageing, and therapeutic antioxidant interventions
10.1016/s1357-2725(02)00086-9 · 2002 · External reference
Extension of life-span with superoxide dismutase/catalase mimetics
10.1126/science.289.5484.1567 · 2000 · External reference
Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular
10.1016/s0021-9258(18)41568-2 · 1993 · External reference
Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity
10.1002/1097-0215(20001101)88:3<351::aid-ijc5>3.0.co;2-h · 2000 · External reference
Extending life: scientific prospects and political obstacles
10.1111/1468-0009.00006 · 2002 · External reference
Defending genomic stability over life span: a proposed role for PARP-1
10.1016/s0531-5565(00)00144-3 · 2000 · External reference
Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians
10.1007/s001090050226 · 1998 · External reference
Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci
10.1007/s004390050735 · 1998 · External reference
Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose) polymerase-1 deficient mice
10.1093/emboj/18.16.4446 · 1999 · External reference
Mitochondrial oxidative stress and ageing in the filamentous fungus Podospora anserina
10.1111/j.1749-6632.2000.tb06633.x · 2000 · External reference
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
10.1038/534 · 1998 · External reference
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins
10.1074/jbc.m006520200 · 2000 · External reference
Biomarkers of caloric restriction may predict longevity in humans
10.1126/science.1071851 · 2002 · External reference
Treatment with l-deprenyl prolongs life in elderly dogs
10.1016/s0024-3205(97)00611-5 · 1997 · External reference
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken
10.1073/pnas.93.15.7481 · 1996 · External reference
Genetic associations with human longevity at the APOE and ACE loci
10.1038/ng0194-29 · 1994 · External reference
A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage
10.1073/pnas.92.11.4753 · 1995 · External reference
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base-excision DNA repair in association with PARP-1 and XRCC1
10.1074/jbc.m202390200 · 2002 · External reference
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers
10.1074/jbc.273.46.30069 · 1998 · External reference
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy
10.1093/nar/29.3.841 · 2001 · External reference
Genetics of human ageing. The search for genes contributing to human longevity and diseases of the old
10.1111/j.1749-6632.2000.tb06635.x · 2000 · External reference
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
10.1126/science.282.5393.1484 · 1998 · External reference
Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males
10.1016/s0197-4580(97)00009-2 · 1997 · External reference
Age-related alteration of poly(ADP-ribose) polymerase activity in different parts of the brain
10.18388/abp.2000_4012 · 2000 · External reference
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
10.1093/genetics/161.2.661 · 2002 · External reference
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
10.1016/s0165-6147(98)01193-6 · 1998 · External reference
Influence of major histocompatibility complex region genes on human longevity among Okinawan–Japanese centenarians and nonagenarians
10.1016/s0140-6736(87)91015-4 · 1987 · External reference
The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine hydroxylase gene). A relative risk approach
10.1016/s0047-6374(02)00081-7 · 2002 · External reference
The social implications of an ageing population. Introduction
10.1016/s0047-6374(01)00418-3 · 2002 · External reference
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity
10.1093/carcin/22.1.1 · 2001 · External reference
PARP is important for genomic stability but dispensable in apoptosis
10.1101/gad.11.18.2347 · 1997 · External reference
Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-α genes in Finnish nonagenarians
10.1016/s0047-6374(01)00338-4 · 2001 · External reference
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
10.1126/science.1072221 · 2002 · External reference
