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References from Age-related changes in vascular adrenergic signaling: clinical and mechanistic implications. Local targets link to admitted publications; unresolved targets remain external evidence.
The caveolin membrane system
10.1146/annurev.biochem.67.1.199 · 1998 · External reference
Vascular β-adrenoceptor-medaited vasorelaxation and tone of the tissues of the canine artery
10.1111/j.2042-7158.1995.tb05840.x · 1995 · External reference
β-Adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
10.1073/pnas.83.9.2797 · 1986 · External reference
Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal trandsduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11)
10.1046/j.1471-4159.1997.69020570.x · 1997 · External reference
Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium
10.1677/joe.0.1620401 · 1999 · External reference
Parrallel modulation of catecholamine activation of adenylyl cyclase and formation of the high-affinity agonist–receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid
10.1021/bi00560a012 · 1980 · External reference
Angiotensin II potentiates vasodilation of rat aorta by cAMP elevating agonists
1997 · External reference
Dissecting receptor-G protein specificity using G alpha chimeras
10.1016/s0076-6879(02)44706-4 · 2002 · External reference
Aging and red blood cell membrane: a study of centenarians
10.1016/s0531-5565(98)00055-2 · 1999 · External reference
Regulation of G-protein receptor kinases by caveolin
10.1074/jbc.274.13.8858 · 1999 · External reference
Unresolved reference
External reference
Impaired cholera toxin relaxation with age in rat aorta
10.1093/gerona/54.4.b154 · 1999 · External reference
A region of adenylyl cyclase 2 critical for tregulation by G protein beta/gamma subunits
10.1126/science.7761832 · 1995 · External reference
Targeted disruption of the β2 adrenergic receptor gene
10.1074/jbc.274.24.16694 · 1999 · External reference
Phosphorylation and activation of beta-adrenergic receptor kinase by protein kinase C
10.1074/jbc.270.31.18660 · 1995 · External reference
Age-related modification of dopaminergic and β-adrenergic receptor system: restoration to normal activity by modifing membrane fluidity with S-adenosylmethionine
10.1016/0024-3205(84)90367-9 · 1984 · External reference
G protein βγ subunits
10.1146/annurev.pharmtox.37.1.167 · 1997 · External reference
β2-Adrenoceptor polymorphism determines vascular reactivity in humans
10.1161/01.hyp.36.3.371 · 2000 · External reference
Age-related changes in vascular responsiveness to cyclic nucleotides and contractile agents
1974 · External reference
AKAPs: from structure to function
10.1016/s0962-8924(99)01558-5 · 1999 · External reference
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
10.1074/jbc.m009130200 · 2001 · External reference
Molecular and cellular biology of caveolae
10.1016/s1050-1738(97)00001-7 · 1997 · External reference
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
10.1038/36362 · 1997 · External reference
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
2000 · External reference
Role of cyclic AMP-dependent protein kinase in the diminished beta-adrenergic responsiveness of vascular smooth muscle with increasing age
1989 · External reference
A ternary complex model explains the agonist-specific binding properties of adenylate cyclase coupled β-adrenergic receptor
10.1016/s0021-9258(20)79672-9 · 1980 · External reference
The effect of common polymorphisms of the β2-adrenergic receptor on agonist-mediated vascular desensitization
10.1056/nejmoa010819 · 2001 · External reference
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
10.1126/science.1062688 · 2001 · External reference
Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure
10.1124/mol.61.4.749 · 2002 · External reference
Age-dependent variations in β-receptor activity and cyclic AMP in vascular smooth muscle
1972 · External reference
Adrenergic β-receptor activity and cyclic AMP metabolism in vascular smooth muscle variations with age
10.1016/0047-6374(75)90002-0 · 1975 · External reference
The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the β2-adrenergic receptor via the receptor cytoplasmic arg-329 to leu-413 domain and provides a mobile scaffold during desensitization
10.1074/jbc.m011199200 · 2001 · External reference
Molecular glue: kinase anchoring and scaffold proteins
10.1016/s0092-8674(00)81075-2 · 1996 · External reference
Further studies on the effect of aging in β-adrenoceptor activity in rat aorta
10.1111/j.1476-5381.1971.tb07115.x · 1971 · External reference
Age-related decrease in beta adrenoceptor activity of the cardiovascular system
10.1016/0165-6147(81)90359-x · 1981 · External reference
Beta receptor activity in aorta: variations with age and species
10.1161/01.res.26.2.151 · 1970 · External reference
Effect of maturation and aging on β-adrenergic signal transduction in the rat kidney and liver
10.1016/s0006-2952(00)00493-7 · 2000 · External reference
Assembly of an A-kinase anchoring protein–β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling
10.1016/s0960-9822(00)00419-x · 2000 · External reference
Identification of the G protein-coupled receptor kinases phosphorylation sites in the human β-adrenergic receptor
10.1074/jbc.271.23.13796 · 1996 · External reference
Phosphorylation and desensitization of the human β1-adrenergic receptor—involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase
10.1074/jbc.270.30.17953 · 1995 · External reference
Beta 2-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for Gs/Gi switching
10.1124/mol.62.5.1094 · 2002 · External reference
Impaired isoproterenol-induced hyperpolarization in isolated mesenteric arteries of aged rats
10.1161/01.hyp.34.2.222 · 1999 · External reference
Enhanced vasorelaxation by overexpression of β2-adrenergic receptors in large arteries
10.1006/jmcc.1998.0668 · 1998 · External reference
Vascular β-adrenergic receptor adenylyl cyclase system in maturation and aging
10.1006/jmcc.2000.1210 · 2000 · External reference
cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits
10.1016/s0896-6273(00)80358-x · 1997 · External reference
G-protein-coupled receptor kinase activity is increased in hypertension
10.1172/jci119381 · 1997 · External reference
Vascular adenoreceptors: an update
2001 · External reference
β-Adrenoceptor–Gαs coupling decreases with age in rat aorta
1995 · External reference
How activated receptors couple to G proteins
10.1073/pnas.011099798 · 2001 · External reference
Effect of aging on plasma membrane fluidity of rat aortic endothelial cells
10.1016/s0531-5565(99)00025-x · 1999 · External reference
Vascular smooth muscle. A review of the molecular basis of contractility
10.1161/01.cir.83.2.382 · 1991 · External reference
Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization
10.1016/s0021-9258(18)63907-9 · 1989 · External reference
Effects of Bay K 8644 in aorta from spontaneously hypertensive and Wistar Kyoto rats of different ages
10.1111/j.1474-8673.1995.tb00309.x · 1995 · External reference
Altered beta-adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer donors
10.1016/s0021-9258(18)82377-8 · 1993 · External reference
Structure, mechanism, and regulation of mammalian adenylyl cyclase
10.1074/jbc.274.12.7599 · 1999 · External reference
β2 Adrenoceptor-mediated relaxation of the isolated human saphenous vein
1987 · External reference
Angiotensin receptor subtype 1 mediates angiotensin II enhancement of isoproterenol-induced cyclic AMP production in preglomerular microvascular smooth muscle cells
1999 · External reference
Adrenergic receptors, G proteins, and cell regulation: implications for aging
10.1016/0531-5565(93)90061-h · 1993 · External reference
Ion channels and vascular tone
10.1161/01.hyp.35.1.173 · 2000 · External reference
Reduced G protein function in desensitized rat aorta
1991 · External reference
Expression of G-protein-alpha subunits in the aging cardiovascular system
10.1093/gerona/50a.1.b14 · 1995 · External reference
Signaling networks: the origins of cellular multitasking
10.1016/s0092-8674(00)00112-4 · 2000 · External reference
Changes in caveolin subtype protein expression in aging rat organs
10.1016/s0303-7207(01)00472-5 · 2001 · External reference
10.1016/0014-2999(91)90618-z
10.1016/0014-2999(91)90618-z · External reference
Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons
10.1073/pnas.93.13.6753 · 1996 · External reference
The role of receptor kinases and arrestins in G-protein-coupled receptor regulation
10.1146/annurev.pharmtox.38.1.289 · 1998 · External reference
Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells
1993 · External reference
Dancing with different partners: protein kinase A phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity
10.1124/mol.62.5.971 · 2002 · External reference
Evidence for a regulated interaction between heterotrimeric G proteins and caveolin
10.1074/jbc.270.26.15693 · 1995 · External reference
Src tyrosine kinases, Gα subunits and H-ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of src tyrosine kinases
10.1074/jbc.271.46.29182 · 1996 · External reference
Structural basis for receptor subtype-specific regulation revealed by a chimeric β3/β2-adrenergic receptor
10.1073/pnas.90.8.3665 · 1993 · External reference
10.1016/s0021-9258(19)39754-6
10.1016/s0021-9258(19)39754-6 · External reference
β-Arrestin: a protein that regulates β-adrenergic receptor function
10.1126/science.2163110 · 1990 · External reference
Age-related changes in adenylyl cyclase activity in rat aorta membranes
10.1016/s0047-6374(97)00168-1 · 1998 · External reference
Age-related changes in G proteins in rat aorta
10.1093/gerona/51a.2.b111 · 1996 · External reference
Cyclic nucleotide-dependent relaxation in vascular smooth muscle
10.1139/y94-199 · 1994 · External reference
AKAP-mediated signal transduction
10.1146/annurev.pharmtox.42.083101.135801 · 2002 · External reference
Expanding roles for β-arrestins as scaffolds and adaptors in G protein-coupled receptor signaling and trafficking
10.1016/s0955-0674(00)00190-3 · 2001 · External reference
Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats
1998 · External reference
Angiotensin II and phorbol ester enhance isoproterenol- and vasoactive intestinal peptide (VIP)-induced cyclic AMP accumulation in vascular smooth muscle cells
10.1016/0006-291x(85)91765-6 · 1985 · External reference
Membrane organization in G-protein mechanisms
10.1096/fasebj.8.12.8088459 · 1994 · External reference
Effect of age on plasma membrane asymmetry and membrane fluidity in human leukocytes and plateletes
10.1093/gerona/54.12.m601 · 1999 · External reference
Beta-1 and beta-2 adrenoceptor-mediated responses in preparations of pulmonary artery and aorta from young and aged rats
1984 · External reference
Thyroxine treatment of aged or young rats demonstrates that vascular responses mediated by beta-adrenoceptor subtypes can be differentially regulated
10.1111/j.1476-5381.1986.tb09469.x · 1986 · External reference
Age influences responses of rat isolated aorta and pulmonary artery to the calcium channel agonsit, Bay K 8664, and to potassium and calcium
10.1097/00005344-198905000-00005 · 1989 · External reference
Downregulation of caveolin by chronic beta-adrenergic receptor stimulation in mice
10.1152/ajpcell.1997.273.6.c1957 · 1997 · External reference
Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane
10.1074/jbc.273.10.5419 · 1998 · External reference
Atypical beta-adrenoceptors in the rat isolated common carotid artery
10.1111/j.1476-5381.1994.tb17049.x · 1994 · External reference
Different atypical beta-adrenoceptors mediate isoprenaline-induced vasorelaxation in vascular and non-vascualr smooth muscle
10.1016/0024-3205(95)00076-3 · 1995 · External reference
Coupling of catecholamine receptors from one cell with adenylyl cyclase from another cell by cell fusion
10.1073/pnas.73.12.4410 · 1976 · External reference
Adrenergic mechanisms in blood vessels: morphological and pharmacological aspects
10.1007/bfb0031007 · 1983 · External reference
Caveolar microdomains of the sarcolemma: compartmentation of signaling molecules comes of age
10.1161/01.res.84.9.1110 · 1999 · External reference
Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes
2000 · External reference
Decline in beta-adrenergic receptor-mediated vascular relaxation with aging in man
1986 · External reference
G protein-coupled receptor kinases
10.1146/annurev.biochem.67.1.653 · 1998 · External reference
The influence of animal age on β-adrenoceptor density and function in trachial airway smooth muscle
10.1007/s002109900051 · 1999 · External reference
10.1074/jbc.m105408200
10.1074/jbc.m105408200 · External reference
Caveolin-deficient mice: insights into caveolar function and human diseases
10.1172/jci200114611 · 2001 · External reference
Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A
10.1152/ajpcell.2001.281.4.c1241 · 2001 · External reference
Unresolved reference
External reference
Regulation of contraction an relaxation in arterial smooth muscle
10.1161/01.hyp.20.2.129 · 1992 · External reference
Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity
10.1038/276394a0 · 1978 · External reference
Seven-transmembrane-spanning receptors and heart function
10.1038/415206a · 2002 · External reference
Cardiovascular and metabolic alterations in mice lacking Both β1- and β2-adrenergic receptors
10.1074/jbc.274.24.16701 · 1999 · External reference
G protein-dependent signaling and ageing
10.1016/s0531-5565(99)00092-3 · 2000 · External reference
Unresolved reference
External reference
Comparative rates of desensitization of β-adrenergic receptors by the β-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase
10.1073/pnas.88.14.6201 · 1991 · External reference
Relationships between beta- and alpha2-adrenoceptors and G coupling proteins in the human brain: effects of age and suicide
10.1016/s0006-8993(01)02190-4 · 2001 · External reference
Decreased receptor activation with age. Can it be explained by desensitization?
10.1111/j.1532-5415.1988.tb04379.x · 1988 · External reference
Cholesterol modulation of beta-adrenergic receptor characteristics
10.1016/0167-4889(85)90220-4 · 1985 · External reference
β-Adrenergic function in aging. Basic mechanisms and clinical implications
10.2165/00002512-199101020-00004 · 1991 · External reference
Age-related differences in cyclic AMP metabolism and their consequences on relaxation induced by isoproterenol and phosphodiesterase inhibitors in rat isolated aorta
10.1016/0047-6374(90)90050-p · 1990 · External reference
Viral-mediated gene delivery of constitutively activated Gαs alters vasoreactivity
10.1046/j.1440-1681.2000.03210.x · 2000 · External reference
Angiotensin II enhances β-adrenergic receptor-mediated vasorelaxation in aorta from young but not old rats
2000 · External reference
Upregulation of G protein-linked receptor kinases with advancing age in rat aorta
2001 · External reference
Unresolved reference
External reference
Colocalization of β-adrenergic receptors and caveolin within the plasma membrane
10.1002/(sici)1097-4644(19991001)75:1<64::aid-jcb7>3.0.co;2-l · 1999 · External reference
Compartmentation of cyclic adenosine 3′,5′-monophosphate signaling in caveolae
10.1210/me.13.7.1061 · 1999 · External reference
Desensitizaztion of norepinephrine receptor function is associated with G protein uncoupling in the rat aorta
1997 · External reference
Role of plasmalemmal caveolae in signal transduction
1998 · External reference
Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization
10.1073/pnas.91.25.12193 · 1994 · External reference
Protein kinase C deficiency blocks recovery from agonist induced desensitization
10.1074/jbc.271.35.21478 · 1996 · External reference
Dynamic complexes of β2-adrenergic receptors with protein kinases and phosphatases and the role of gravin
10.1074/jbc.274.3.1588 · 1999 · External reference
Caveolins, liquid-ordered domains, and signal transduction
10.1128/mcb.19.11.7289 · 1999 · External reference
Binding of purified recombinant β-arrestin to guanine-nucleotide-binding-protein-coupled receptors
10.1111/j.1432-1033.1995.tb20832.x · 1995 · External reference
Cell calcium and its regulation in smooth muscle
10.1096/fasebj.3.11.2506092 · 1989 · External reference
Signal transduction and regulation in smooth muscle
10.1038/372231a0 · 1994 · External reference
Pharmacomechanical coupling: the role of calcium, G-proteins, kinases, and phosphatases
1999 · External reference
Complexity and diversity of mammalian adenylyl cyclases
10.1146/annurev.pa.36.040196.002333 · 1996 · External reference
Model of coupling between the β-adrenergic receptor and adenylyl cyclase in turkey erythrocytes
10.1021/bi00611a020 · 1978 · External reference
Inhibition of adenylyl cyclase by caveolin peptides
10.1210/en.139.4.2025 · 1998 · External reference
Age-related decrease in beta-adrenergic receptor-mediated vascular smooth muscle relaxation
1986 · External reference
Effects of thyroid hormone on beta-adrenergic responsiveness of aging cardiovascualr systems
1987 · External reference
Geriatric pharmacology: basic and clinical considerations
10.1146/annurev.pa.32.040192.001415 · 1992 · External reference
Altered expression of β-adrenergic receptor kinase in β1-adrenergic receptors in the failing human heart
10.1161/01.cir.87.2.454 · 1993 · External reference
Regulation of vascular smooth muscle tone
10.1139/y94-130 · 1994 · External reference
Vascular β-adrenoceptor function in hypertension and aging
10.1139/y00-015 · 2000 · External reference
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C
10.1073/pnas.93.5.2105 · 1996 · External reference
Age-associated reductions in cardiac β1- and β2-adrenergic responses without changes in G proteins or receptor kinases
10.1172/jci1335 · 1998 · External reference
Coupling of β2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes
10.1161/01.res.84.1.43 · 1999 · External reference
Recent advances in cardiac β2-adrenergic signal transduction
10.1161/01.res.85.11.1092 · 1999 · External reference
A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart
10.1083/jcb.142.2.511 · 1998 · External reference
Regulation of PKA binding to AKAPs in the heart. Alterations in human heart failure
10.1161/01.cir.101.12.1459 · 2000 · External reference
Adenylyl cyclase isoforms and vasopressin enhancement of agonist-stimulated cAMP in vascular smooth muscle cells
1997 · External reference
RGS-PX1, a GAP for Gαs and sorting nexin in vesicular trafficking
10.1126/science.1064757 · 2001 · External reference
Anchoring protein is required for cAMP-dependent stimulation of L-type Ca(2+) channels in rabbit portal vein
10.1152/ajpcell.1999.277.4.c840 · 1999 · External reference