Research graph
References from Targeting DNA methylation in cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
The DNMT1 target recognition domain resides in the N-terminus
10.1074/jbc.m009037200 · 2001 · External reference
Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA
10.1074/jbc.274.46.33011 · 1999 · External reference
DNA hypermethylation in tumorigenesis: epigenetics joins genetics
10.1016/s0168-9525(99)01971-x · 2000 · External reference
An essential role for DNA methyltransferase DNMT3B in cancer cell survival
10.1074/jbc.m204734200 · 2002 · External reference
A mammalian protein with specific demethylase activity for mCpG DNA [see comments]
10.1038/17533 · 1999 · External reference
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase
10.1074/jbc.274.8.4594 · 1999 · External reference
MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland
10.1038/sj.onc.1205357 · 2002 · External reference
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality
10.1128/mcb.22.7.2124-2135.2002 · 2002 · External reference
CpG-rich islands and the function of DNA methylation [review] [61 refs.]
10.1038/321209a0 · 1986 · External reference
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
10.1038/5047 · 1999 · External reference
Demethylase activity is directed by histone acetylation
10.1074/jbc.m103921200 · 2001 · External reference
The oncoprotein Set/TAF-1β, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing
10.1074/jbc.m202256200 · 2002 · External reference
DNA hypomethylation leads to elevated mutation rates
10.1038/25779 · 1998 · External reference
AdoMet-dependent methylation, DNA methyltransferases and base flipping
10.1093/nar/29.18.3784 · 2001 · External reference
Human DNA-(cytosine-5) methyltransferase–PCNA complex as a target for p21WAF1
10.1126/science.277.5334.1996 · 1997 · External reference
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2
10.1093/nar/18.13.3975 · 1990 · External reference
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
1999 · External reference
A conserved 3′-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity
10.1074/jbc.m103056200 · 2001 · External reference
Promoter-specific activation and demethylation by MBD2/demethylase
10.1074/jbc.c200408200 · 2002 · External reference
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
10.1126/science.1065173 · 2002 · External reference
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression [published erratum appears in Cancer Res. 1999 Nov. 15;59(22):5860]
1999 · External reference
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements
10.1093/jn/132.8.2424s · 2002 · External reference
DNA methylation in cancer: too much, but also too little
10.1038/sj.onc.1205651 · 2002 · External reference
Hypomethylation and hypermethylation of DNA in Wilms tumors
10.1038/sj.onc.1205890 · 2002 · External reference
Hypomethylation of ras oncogenes in primary human cancers
10.1016/s0006-291x(83)80115-6 · 1983 · External reference
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(INK4A) and p21(WAF/CIP1) by distinct mechanisms
10.1074/jbc.274.34.24250 · 1999 · External reference
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
10.1038/71750 · 2000 · External reference
Regulation of DNA methylation in human breast cancer. Effect on the Urokinase-Type Plasminogen Activator gene production and tumor invasion
10.1074/jbc.m201864200 · 2002 · External reference
Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine
10.1007/bf00135878 · 1990 · External reference
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
10.1073/pnas.96.25.14412 · 1999 · External reference
DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers
10.1177/147323000102900308 · 2001 · External reference
Identification and characterization of a family of mammalian methyl-CpG binding proteins
10.1128/mcb.18.11.6538 · 1998 · External reference
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
10.1101/gad.194101 · 2001 · External reference
Increased cytosine DNA-methyltransferase activity during colon cancer progression
10.1093/jnci/85.15.1235 · 1993 · External reference
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation [in process citation]
10.1038/83730 · 2001 · External reference
DNA demethylation and pericentromeric rearrangements of chromosome 1
10.1016/s0027-5107(97)00088-2 · 1997 · External reference
Altering gene expression with 5-azacytidine
10.1016/0092-8674(85)90192-8 · 1985 · External reference
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
10.1038/561 · 1998 · External reference
Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase
10.1074/jbc.270.17.9734 · 1995 · External reference
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers
10.1006/bbrc.1999.1613 · 1999 · External reference
Effect of regional DNA methylation on gene expression
10.1073/pnas.82.9.2560 · 1985 · External reference
A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus
10.1038/ng0895-435 · 1996 · External reference
Inhibition of DNA methyltransferase inhibits DNA replication
10.1074/jbc.c900894199 · 2000 · External reference
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells
10.1093/nar/gkf593 · 2002 · External reference
Suppression of intestinal neoplasia by DNA hypomethylation
10.1016/0092-8674(95)90329-1 · 1995 · External reference
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
10.1073/pnas.93.19.10366 · 1996 · External reference
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
10.1016/0092-8674(92)90561-p · 1992 · External reference
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
10.1128/mcb.22.2.480-491.2002 · 2002 · External reference
Modulation of DNA binding protein affinity directly affects target site demethylation
10.1128/mcb.20.7.2343-2349.2000 · 2000 · External reference
10.1074/jbc.m008234200
10.1074/jbc.m008234200 · External reference
Regulation of DNA methylation by the Ras signaling pathway
10.1074/jbc.270.19.11327 · 1995 · External reference
Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells
10.1093/jnci/92.15.1210 · 2000 · External reference
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/SDI1)
10.1074/jbc.275.9.6353 · 2000 · External reference
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
10.1016/s0092-8674(00)81887-5 · 1997 · External reference
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex [see comments]
10.1038/30764 · 1998 · External reference
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex [see comments]
10.1038/12659 · 1999 · External reference
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
10.1016/s0092-8674(00)81656-6 · 1999 · External reference
Active demethylation of the paternal genome in the mouse zygote
10.1016/s0960-9822(00)00448-6 · 2000 · External reference
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4A protein induction by 5-azaC 2′ deoxycytidine
1995 · External reference
Dynamics of demethylation and activation of the α-actin gene in myoblasts
10.1016/0092-8674(90)90418-e · 1990 · External reference
Reversal by 5-azacytidine of the S-adenosyl-l-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis
10.1016/0304-3835(91)90011-6 · 1991 · External reference
Chemoprevention of hepatocarcinogenesis. S-Adenosyl-l-methionine
10.1016/s0741-8329(02)00227-6 · 2002 · External reference
DNA methyltransferase and demethylase in human prostate cancer
10.1002/mc.10033 · 2002 · External reference
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction
10.1093/jn/132.8.2336s · 2002 · External reference
Methyl supply, methyl metabolizing enzymes and colorectal neoplasia
10.1093/jn/132.8.2410s · 2002 · External reference
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide
10.1073/pnas.94.2.684 · 1997 · External reference
Genomic structure of the human DNA methyltransferase gene
1998 · External reference
DNA methylation is a reversible biological signal [see comments]
10.1073/pnas.96.11.6107 · 1999 · External reference
Distribution of 5-methylcytosine in chromatin
10.1073/pnas.74.7.2725 · 1977 · External reference
DNA methylation and gene function
10.1126/science.6254144 · 1980 · External reference
DNA methylation patterns. Formation and function
10.1016/0167-4781(84)90043-5 · 1984 · External reference
Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation
10.1073/pnas.83.9.2827 · 1986 · External reference
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
10.1038/77124 · 2000 · External reference
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
10.1038/77023 · 2000 · External reference
The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4A) and RASSF1A in human lung cancer cell lines
10.1038/sj.onc.1205581 · 2002 · External reference
Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets
2002 · External reference
DNA, FISH and complementation studies in ICF syndrome: DNA hypomethylation of repetitive and single copy loci and evidence for a trans acting factor
10.1007/bf00197412 · 1995 · External reference
Trichostatin A causes selective loss of DNA methylation in Neurospora
10.1073/pnas.95.16.9430 · 1998 · External reference
Antisense MBD2 gene therapy inhibits tumorigenesis
10.1002/jgm.288 · 2002 · External reference
The language of covalent histone modifications
10.1038/47412 · 2000 · External reference
DNA methylation patterns: an additional level of information?
10.1139/o91-117 · 1991 · External reference
The DNA methylation machinery as a target for anticancer therapy
10.1016/0163-7258(96)00002-2 · 1996 · External reference
Towards a pharmacology of DNA methylation
10.1016/s0165-6147(00)01713-2 · 2001 · External reference
Cellular and viral DNA hypomethylation associated with induction of Epstein–Barr virus lytic cycle
10.1073/pnas.82.23.8090 · 1985 · External reference
Nucleotide-sequence-specific de novo methylation in a somatic murine cell line
10.1073/pnas.86.18.6853 · 1989 · External reference
Modification of the metastatic potential of tumor cells by drugs
10.1007/bf00046423 · 1986 · External reference
A histone H3 methyltransferase controls DNA methylation in Neurospora crasa
10.1038/35104508 · 2001 · External reference
DNA methyltransferase in normal and Dnmtn/Dnmtn mouse embryos
10.1002/(sici)1097-0177(199607)206:3<239::aid-aja2>3.0.co;2-j · 1996 · External reference
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
10.1128/mcb.16.8.4555 · 1996 · External reference
Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment
2000 · External reference
On the mechanism and inhibition of DNA cytosine methyltransferases
1985 · External reference
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells [see comments]
10.1073/pnas.90.19.8891 · 1993 · External reference
Analysis of the NurD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
10.1101/gad.13.15.1924 · 1999 · External reference
5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence
10.1093/nar/28.21.4157 · 2000 · External reference
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex
10.1073/pnas.100107597 · 2000 · External reference
Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene
10.1073/pnas.091097298 · 2001 · External reference
