Research graph
References from Caspases, apoptosis and aging. Local targets link to admitted publications; unresolved targets remain external evidence.
Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
10.4049/jimmunol.160.4.1627 · 1998 · External reference
Increased activity of caspase-3 and caspase-8 in anti-Fas-induced apoptosis in lymphocytes from ageing humans
10.1046/j.1365-2249.1999.00957.x · 1999 · External reference
Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases
10.4049/jimmunol.162.4.2154 · 1999 · External reference
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
10.1083/jcb.200207071 · 2002 · External reference
Neuronal apoptosis in mouse trisomy 16: mediation by caspases
10.1046/j.1471-4159.1999.721769.x · 1999 · External reference
All in the family: evolutionary and functional relationships among death receptors
10.1038/sj.cdd.4401174 · 2003 · External reference
Biochemical pathways of caspase activation during apoptosis
10.1146/annurev.cellbio.15.1.269 · 1999 · External reference
The Apaf-1 apoptosome: a large caspase-activating complex
10.1016/s0300-9084(02)01376-7 · 2002 · External reference
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria
10.1016/s0300-9084(02)01374-3 · 2002 · External reference
IAP family proteins—suppressors of apoptosis
10.1101/gad.13.3.239 · 1999 · External reference
The roles of Bid
10.1023/a:1020035124855 · 2002 · External reference
Many cuts to ruin: a comprehensive update of caspase substrates
10.1038/sj.cdd.4401160 · 2003 · External reference
Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition
10.1016/s1074-7613(03)00032-3 · 2003 · External reference
Molecular and biochemical pathways of apoptosis in lymphocytes from aged humans
10.1016/s0264-410x(99)00492-2 · 2000 · External reference
Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNF-RI and downstream signaling molecules
10.1016/s0531-5565(01)00195-4 · 2002 · External reference
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
10.1016/s0304-3940(02)00705-x · 2002 · External reference
Increased susceptibility to apoptosis induced by anti-Fas antibody in a Rothmund–Thomson syndrome lymphoblastoid cell line
1998 · External reference
Noncaspase proteases in apoptosis
10.1038/sj.leu.2401879 · 2000 · External reference
Apoptosis: a link between cancer genetics and chemotherapy
10.1016/s0092-8674(02)00625-6 · 2002 · External reference
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer’s disease and Down’s syndrome brain
10.1007/s00401-002-0548-2 · 2002 · External reference
Aging splenocyte and thymocyte apoptosis is associated with enhanced expression of p53, bax, and caspase-3
10.1006/mcbr.1999.0106 · 1999 · External reference
Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics
10.1038/bjc.1972.33 · 1972 · External reference
Apoptosis: its significance in cancer and cancer therapy
10.1002/1097-0142(19940415)73:8<2013::aid-cncr2820730802>3.0.co;2-j · 1994 · External reference
Disease model: human aging
10.1016/s1471-4914(01)01921-9 · 2001 · External reference
Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals
10.1016/s0047-6374(02)00005-2 · 2002 · External reference
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
10.1073/pnas.95.22.13097 · 1998 · External reference
Endonuclease G is an apoptotic DNase when released from mitochondria
10.1038/35083620 · 2001 · External reference
The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation
10.1046/j.1460-9568.2002.02012.x · 2002 · External reference
Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid
10.1074/jbc.m205289200 · 2002 · External reference
Apoptosis in neurodegenerative disorders
10.1038/35040009 · 2000 · External reference
Parkinson’s disease: changes in apoptosis-related factors suggesting possible gene therapy
10.1007/s007020200061 · 2002 · External reference
The Bcl-2 family and cell death regulation
10.1016/s0959-437x(98)80064-6 · 1998 · External reference
Mitochondria: regulating the inevitable
10.1016/s0300-9084(02)01380-9 · 2002 · External reference
The CD95 (APO-1/Fas) DISC and beyond
10.1038/sj.cdd.4401186 · 2003 · External reference
Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age
10.1152/ajpregu.00296.2001 · 2002 · External reference
The role of apoptosis in the normal aging brain, skeletal, muscle, and heart
10.1111/j.1749-6632.2002.tb02086.x · 2002 · External reference
Mouse models of cell death
10.1038/88815 · 2001 · External reference
Apoptosis in AIDS
10.1023/a:1009636530839 · 2001 · External reference
Caspase activation: the induced-proximity model
10.1073/pnas.96.20.10964 · 1999 · External reference
IAP proteins: blocking the road to death’s door
10.1038/nrm830 · 2002 · External reference
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer’s disease and Down’s syndrome brain
10.1007/s00401-002-0548-2 · 2002 · External reference
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors
10.1016/s1074-7613(03)00050-5 · 2003 · External reference
Apoptosis in Alzheimer’s disease—an update
10.1023/a:1009625323388 · 2000 · External reference
The biology of aging
2003 · External reference
Cell death regulation by the Bcl-2 protein family in the mitochondria
10.1002/jcp.10254 · 2003 · External reference
Cell death regulation by the mammalian IAP antagonist Diablo/Smac
10.1023/a:1014318615955 · 2002 · External reference
Apoptosis: a two-edged sword in aging
10.1111/j.1749-6632.1999.tb07917.x · 1999 · External reference
Effect of age and apoptosis on the mouse homologue of the huWRN gene
10.1016/s0047-6374(98)00008-6 · 1998 · External reference
Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa
10.1016/s0047-6374(01)00323-2 · 2001 · External reference
Molecular control of life and death
10.1016/0955-0674(95)80030-1 · 1995 · External reference
Aging and apoptosis
10.1016/s0047-6374(01)00349-9 · 2002 · External reference
Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells
10.1016/s0047-6374(01)00412-2 · 2002 · External reference
Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs
10.1016/s0531-5565(02)00013-x · 2002 · External reference
