Research graph
References from Neuronal and microglial cathepsins in aging and age-related diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron
10.1016/0047-6374(95)01615-7 · 1995 · External reference
Cytosolic proteolysis of τ by cathepsin D in hippocampus following suppression of cathepsins B and L
10.1046/j.1471-4159.1996.67051846.x · 1996 · External reference
Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus
10.1523/jneurosci.17-11-04006.1997 · 1997 · External reference
Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type
1989 · External reference
An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains
10.1016/0006-8993(94)91509-1 · 1994 · External reference
Enzymatically active lysosomal proteinases are associated with amyloid deposits in Alzheimer brain
10.1073/pnas.87.10.3861 · 1990 · External reference
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
10.1016/0006-8993(94)91858-9 · 1990 · External reference
Lysosomal hydrorases of different classes are abnormally distributed in brains of patients with Alzheimer disease
10.1073/pnas.88.24.10998 · 1991 · External reference
Cathepsin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α
10.1002/j.1460-2075.1996.tb00760.x · 1996 · External reference
Cathepsins B and D are dispensable for major histocompatibility complex II-mediated antigen presentation
10.1073/pnas.95.8.4516 · 1998 · External reference
Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
10.1073/pnas.94.8.4080 · 1997 · External reference
Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
10.1038/382716a0 · 1996 · External reference
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
10.1073/pnas.112632299 · 2002 · External reference
Neurodegeneration in the Niemann-Pick C mouse: glial involvement
10.1016/s0306-4522(01)00517-6 · 2002 · External reference
Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts
10.1083/jcb.123.1.99 · 1993 · External reference
Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
10.1172/jci9914 · 2000 · External reference
Identification of β-secretase-like activity using a mass spectrometry-based assay system
10.1038/71944 · 2000 · External reference
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
10.1172/jci9411 · 2000 · External reference
Cathepsin D is involved in the clearance of Alzheimer’s β-amyloid protein
10.1016/0014-5793(96)01087-3 · 1996 · External reference
Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy
10.1073/pnas.93.25.14821 · 1996 · External reference
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrilar β-amyloid
10.1016/s0165-5728(01)00239-9 · 2001 · External reference
Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases
10.1016/s0306-4522(98)00566-1 · 1999 · External reference
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain
10.1126/science.6505679 · 1984 · External reference
Age-related changes in ultrastructural features of cathepsin B- and D-containing neurons in rat cerebral cortex
10.1016/s0006-8993(99)01888-0 · 1999 · External reference
Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins
10.1096/fj.01-0530fje · 2002 · External reference
Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarization and the permeability transition but not by cytochrome c release
10.1046/j.1471-4159.2000.0741452.x · 2001 · External reference
Cathepsin D deficiency induces lysosomal storage with ceroid-lipofuscin in mouse CNS neurons
10.1523/jneurosci.20-18-06898.2000 · 2000 · External reference
Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors
10.1146/annurev.bi.61.070192.001515 · 1992 · External reference
Alzheimer’s disease-related overexpression of cation-dependent mannose 6-phosphate receptor increases Aβ secretion. Role for altered lysosomal hydrolases distribution in β-amyloidogenesis
10.1074/jbc.m108161200 · 2002 · External reference
Age-related increase in a cathepsin D like proteinase that degrades brain microtubule-associated proteins
10.1021/bi00399a010 · 1987 · External reference
Degradation of Alzheimer’s β-amyloid protein by human cathepsin D
10.1097/00001756-199609020-00021 · 1996 · External reference
Activation of microglial cells by β-amyloid protein and interferon-γ
10.1038/374647a0 · 1995 · External reference
Secretion of phosphomannosyl-deficient arylsulphatase A and cathepsin D from isolated human macrophages
10.1042/bj20020249 · 2002 · External reference
Cathepsin L: critical role in Ii degradation and CD4T cell selection in the thymus
10.1126/science.280.5362.450 · 1998 · External reference
Lysosome instability in aged rat brain
10.1016/0304-3940(89)90166-3 · 1989 · External reference
Microglial proteases: strategic targets for neuroprotective agents
10.2174/1570159033360502 · 2003 · External reference
Microglial functions and proteases
10.1385/mn:27:2:163 · 2003 · External reference
Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues
1994 · External reference
Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein
10.1046/j.1471-4159.1997.68020739.x · 1997 · External reference
Involvement of nitric oxide released from microglia/macrophages in pathological changes of cathepsin D-deficient mice
10.1523/jneurosci.21-19-07526.2001 · 2001 · External reference
Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia
10.1074/jbc.m108382200 · 2002 · External reference
A “protease activation cascade” in the pathogenesis of Alzheimer’s disease
10.1111/j.1749-6632.2000.tb05570.x · 2000 · External reference
The lysosomal system in neuronal cell death: a review
10.1111/j.1749-6632.1993.tb18291.x · 1993 · External reference
The endosomal–lysosomal system of neurons: new roles
10.1016/0166-2236(95)92772-i · 1995 · External reference
Bone marrow transplantation prolongs life span and ameliorates neurologic manifestation in Sandhoff disease mice
10.1172/jci2127 · 1998 · External reference
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB
10.1073/pnas.252784899 · 2003 · External reference
Migration of exogenous immature hematopoietic cells into adult mouse brain parenchyma under GFP-expressing bone marrow chimera
10.1006/bbrc.1999.1223 · 1999 · External reference
Microglial cells internalize aggregates of the Alzheimer’s disease amyloid β-protein via scavenger receptor
10.1016/s0896-6273(00)80187-7 · 1996 · External reference
Slow degradation of aggregates of Alzheimer’s disease amyloid β-protein by microglial cells
10.1074/jbc.272.46.29390 · 1997 · External reference
Expression of rat cathepsin S in phagocytic cells
10.1074/jbc.271.8.4403 · 1996 · External reference
Altered antigen expression of microglia in the aged rodent CNS
10.1002/glia.440070111 · 1993 · External reference
Targeting gene-modifies hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engrafment
10.1038/nm1201-1356 · 2001 · External reference
Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L
2001 · External reference
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
10.1096/fj.99-0970com · 2000 · External reference
Microglial cathepsin B: an immunological examination of cellular and secreted species
10.1046/j.1471-4159.1995.65031035.x · 1995 · External reference
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
10.1002/j.1460-2075.1995.tb00029.x · 1995 · External reference
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D
10.1074/jbc.271.44.27241 · 1996 · External reference
Cathepsin B-mediated activation of the proinflammatory caspase-11
10.1006/bbrc.1998.9425 · 1998 · External reference
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
10.1038/22124 · 1999 · External reference
Participation of cathepsin B and D in apoptosis of PC12 cells following serum deprivation
10.1006/bbrc.1998.9422 · 1998 · External reference
Purification and cloning of amyloid precursor protein β-secretase from human brain
10.1038/990114 · 1999 · External reference
Lysosomal protease pathways to apoptosis. Cleavage of Bid, not pro-caspases, is the most likely route
10.1074/jbc.m008944200 · 2001 · External reference
Expression of CD40 in the brain of Alzheimer’s disease and other neurological diseases
10.1016/s0006-8993(00)02984-x · 2000 · External reference
Lysosomal cysteine proteases: more than scavengers
10.1016/s0167-4838(99)00263-0 · 2000 · External reference
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
10.1093/emboj/19.12.2786 · 2000 · External reference
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
10.1016/s0014-5793(98)01275-7 · 1998 · External reference
β-Secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE
10.1126/science.286.5440.735 · 1999 · External reference
Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation
10.1073/pnas.97.20.10954 · 2000 · External reference
Über die Proteased der Magen-schleimahaut. Erste Abhandlung über die Enzyme der Leukozyten
10.1515/bchm2.1929.180.1-3.127 · 1929 · External reference
Potential role for cathepsion D in p53-dependent tumor suppression and chemosensitiivity
10.1038/sj.onc.1201755 · 1998 · External reference
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
10.1016/s0301-0082(00)00006-x · 2000 · External reference
Membrane-anchored aspartyl protease with Alzheimer’s disease β-secretase activity
10.1038/990107 · 1999 · External reference
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1–42 pathogenesis
10.1002/(sici)1097-4547(19980615)52:6<691::aid-jnr8>3.0.co;2-3 · 1998 · External reference
Expression of invariant chain and pro-cathepsin L in Alzheimer’s brain
10.1016/s0304-3940(00)01326-4 · 2000 · External reference
