Research graph
References from Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems. Local targets link to admitted publications; unresolved targets remain external evidence.
Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer’s disease
10.1016/s0306-4522(00)00281-5 · 2000 · External reference
Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction
10.1016/s0047-6374(97)00133-4 · 1998 · External reference
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway
10.1073/pnas.92.23.10599 · 1995 · External reference
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow
10.1016/s0021-9258(17)46660-9 · 1993 · External reference
Oxidants, antioxidants and the degenerative diseases of aging
10.1073/pnas.90.17.7915 · 1993 · External reference
Dietary self-selection can compensate an age-related decrease of rat liver 20S proteasome activity observed with standard diet
10.1093/gerona/53a.3.b173 · 1998 · External reference
Oxidative decay of DNA
10.1074/jbc.272.32.19633 · 1997 · External reference
The free radical theory of aging matures
10.1152/physrev.1998.78.2.547 · 1998 · External reference
Protein oxidation in aging, disease, and oxidative stress
10.1074/jbc.272.33.20313 · 1997 · External reference
4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on Gaq/11
10.1046/j.1471-4159.1997.69020570.x · 1997 · External reference
Stress-inducible mechanisms of life-span extension in yeast, eubacteria, and metazoans
10.1016/s0966-842x(99)01534-6 · 1999 · External reference
Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction
10.1074/jbc.m001083200 · 2000 · External reference
Lipofuscin: mechanisms of age-related accumulation and influence on cell function
10.1016/s0891-5849(02)00959-0 · 2002 · External reference
Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion
10.1074/jbc.m100142200 · 2001 · External reference
Age-related alterations of proteasome structure and function in aging epidermis
10.1016/s0531-5565(00)00136-4 · 2000 · External reference
Age-dependent declines in proteasome activity in the heart
10.1006/abbi.2001.2663 · 2002 · External reference
Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging
10.1074/jbc.270.24.14742 · 1995 · External reference
Mitochondrial free radical generation, oxidative stress, and aging
10.1016/s0891-5849(00)00317-8 · 2000 · External reference
Reversal of age-related increase in brain protein oxidation,decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone
10.1073/pnas.88.9.3633 · 1991 · External reference
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
10.1016/s0304-3940(01)02514-9 · 2002 · External reference
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
10.1073/pnas.87.10.3861 · 1990 · External reference
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease
10.1073/pnas.88.24.10998 · 1991 · External reference
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
10.1016/0006-8993(94)91858-9 · 1994 · External reference
Gene expression and cellular content of cathepsin D in Alzheimer’s disease brain: evidence for early up-regulation of the endosomal-lysosomal system
10.1016/0896-6273(95)90324-0 · 1995 · External reference
Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer’s disease
10.1523/jneurosci.16-01-00186.1996 · 1996 · External reference
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis
10.1523/jneurosci.17-16-06142.1997 · 1997 · External reference
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
10.1016/s0002-9440(10)64538-5 · 2000 · External reference
The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction
10.1016/s0531-5565(00)00224-2 · 2001 · External reference
Role of the proteasome in Alzheimer’s disease
10.1016/s0925-4439(00)00039-9 · 2000 · External reference
Inhibition of adenine nucleotide translocator by lipid peroxidation products
10.1016/0891-5849(95)00066-7 · 1995 · External reference
Inactivation of ribonuclease and other enzymes by peroxidizing lipids and by malonaldehyde
10.1021/bi00835a020 · 1969 · External reference
Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids
10.1021/bi00835a019 · 1969 · External reference
10.1074/jbc.m301048200
10.1074/jbc.m301048200 · External reference
The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators
10.1101/sqb.1995.060.01.053 · 1995 · External reference
Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: immunochemical detection in mitochondria exposed to oxidative stress
10.1006/abbi.1996.0156 · 1996 · External reference
Proteasome inactivation upon aging and on oxidation-effect of HSP 90
10.1023/a:1006852506884 · 1997 · External reference
Structure and functions of the 20S and 26S proteasomes
10.1146/annurev.bi.65.070196.004101 · 1996 · External reference
How do intracellular proteolytic systems change with age?
10.2741/a264 · 1998 · External reference
Age-related decline in chaperone-mediated autophagy
10.1074/jbc.m002102200 · 2000 · External reference
When lysosomes get old
10.1016/s0531-5565(00)00075-9 · 2000 · External reference
Degradation of proteasomes by lysosomes in rat liver
10.1111/j.1432-1033.1995.tb20203.x · 1995 · External reference
I kappa B is a substrate for a selective pathway of lysosomal proteolysis
10.1091/mbc.9.8.1995 · 1998 · External reference
Selectivity of protein oxidative damage during aging in Drosophila melanogaster
10.1042/0264-6021:3600209 · 2001 · External reference
Degradation of oxidized proteins by the 20S proteasome
10.1016/s0300-9084(01)01250-0 · 2001 · External reference
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha
10.1002/j.1460-2075.1996.tb00760.x · 1996 · External reference
The proteasome, a novel protease regulated by multiple mechanisms
10.1074/jbc.274.32.22123 · 1999 · External reference
10.1201/9781498713054
10.1201/9781498713054 · External reference
Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions
10.1093/gerona/56.9.b375 · 2001 · External reference
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
10.1093/gerona/56.7.b288 · 2001 · External reference
Human heptocellular pigments and lysosomes
10.1016/s0022-5320(60)90016-2 · 1960 · External reference
Chemistry and biochemistry of 4-hydroxynonenal malonaldehyde and related aldehydes
10.1016/0891-5849(91)90192-6 · 1991 · External reference
Organelle-specific initiation of cell death pathways
10.1038/ncb1101-e255 · 2001 · External reference
Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein
10.1016/s0014-5793(97)00148-8 · 1997 · External reference
Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease
10.1016/s0021-9258(17)31853-7 · 1994 · External reference
Susceptibility of glucose-6-phosphate dehydrogenase modified by 4-hydroxy-2-nonenal and metal-catalyzed oxidation to proteolysis by the multicatalytic protease
10.1006/abbi.1994.1222 · 1994 · External reference
Protein degradation by the proteasome and its implications in aging
10.1111/j.1749-6632.2000.tb06643.x · 2000 · External reference
Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome
10.1006/abbi.1994.1245 · 1994 · External reference
The permeability transition pore complex: another view
10.1016/s0300-9084(02)01375-5 · 2002 · External reference
Lipofuscin and ceroid formation: the cellular recycling system
1989 · External reference
Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages
10.1172/jci117490 · 1994 · External reference
Evidence that malondialdehyde-derived aminoenimine is not a fluorescent age pigment
10.1021/tx010055u · 2001 · External reference
Structure of a fluorescent compound formed from 4-hydroxy-2-nonenal and N(alpha)-hippuryllysine: a model for fluorophores derived from protein modifications by lipid peroxidation
10.1021/jo971239+ · 1998 · External reference
Detection of lipofuscin-like fluorophore in oxidized human low-density lipoprotein. 4-hydroxy-2-nonenal as a potential source of fluorescent chromophore
10.1016/s0014-5793(00)01539-8 · 2000 · External reference
Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain
10.1126/science.6505679 · 1984 · External reference
Lipofuscin-like substances accumulate rapidly in brain, retina, and internal organs with cysteine protease inhibition
1989 · External reference
Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats
10.1016/0047-6374(91)90048-5 · 1991 · External reference
Kitani K
10.1111/j.1749-6632.1996.tb39048.x · 1996 · External reference
Age-related changes in ultrastructural features of cathepsin B- and D-containing neurons in rat cerebral cortex
10.1016/s0006-8993(99)01888-0 · 1999 · External reference
Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid ß-peptide: role of the lipid peroxidation product 4-hydroxynonenal
10.1046/j.1471-4159.1997.69010273.x · 1997 · External reference
Possible involvement of proteasome inhibition in aging: implications for oxidative stress
10.1016/s0047-6374(99)00101-3 · 2000 · External reference
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
10.1016/s0306-4522(00)00067-1 · 2000 · External reference
Fluorescent and cross-linked proteins formed by free radical and aldehyde species generated during lipid oxidation
1989 · External reference
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers
1989 · External reference
Mitochondrial permeability transition and oxidative stress
10.1016/s0014-5793(01)02316-x · 2001 · External reference
Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
10.1242/jcs.113.20.3613 · 2000 · External reference
Gene expression profile of aging and its retardation by caloric restriction
10.1126/science.285.5432.1390 · 1999 · External reference
Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression
10.1073/pnas.070047997 · 2000 · External reference
Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages
10.1016/s0021-9258(18)98717-x · 1991 · External reference
Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction
10.1073/pnas.95.2.510 · 1998 · External reference
Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase
10.1073/pnas.96.12.6689 · 1999 · External reference
Mitotic misregulation and human aging
10.1126/science.287.5462.2486 · 2000 · External reference
A role for 4-hydroxynonenal in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide
10.1046/j.1471-4159.1997.68010255.x · 1997 · External reference
Amyloid β-peptide impairs glucose uptake in hippocampal and cortical neurons: involvement of membrane lipid peroxidation
10.1523/jneurosci.17-03-01046.1997 · 1997 · External reference
Alzheimer’s disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis
10.1074/jbc.m108161200 · 2002 · External reference
4-Hydroxynonenal, a product of lipid peroxidation inhibits dephosphorylation of the microtubule-associated protein tau
10.1097/00001756-199707070-00036 · 1997 · External reference
Modification of brain, aging, and neurodegenerative disorders by genes, diet, and behavior
10.1152/physrev.00004.2002 · 2002 · External reference
Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease
10.1016/s0006-8993(02)03514-x · 2002 · External reference
Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and Vitamin E deficient rats
10.1007/bf00688154 · 1967 · External reference
Lectin histochemistry of lipofuscin and certain ceroid pigments
10.1007/bf01457543 · 1995 · External reference
How the ubiquitin-proteasome system controls transcription
10.1038/nrm1049 · 2003 · External reference
Immunolocalization of antioxidant enzymes in adult hamster kidney
10.1007/bf00158205 · 1994 · External reference
The endosomal-lysosomal system of neurons in Alzheimer’s disease pathogenesis: a review
10.1023/a:1007675508413 · 2000 · External reference
4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules
10.1074/jbc.274.34.23787 · 1999 · External reference
Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome
10.1016/s0021-9258(18)82272-4 · 1993 · External reference
Ceroid lipofuscinosis in sheep. II. The major component of the lipopigment in liver, kidney, pancreas, and brain is low molecular weight protein
10.1016/s0021-9258(17)36006-4 · 1986 · External reference
10.1007/978-1-4899-5339-1_15
10.1007/978-1-4899-5339-1_15 · External reference
Protein modification by the lipid peroxidation product 4-hydroxynonenal in spinal cord tissue of ALS patients
10.1002/ana.410440518 · 1998 · External reference
Advances in age pigment research
10.1016/0167-4943(91)90036-p · 1991 · External reference
Pigments in aging: an overview
10.1111/j.1749-6632.2002.tb02083.x · 2002 · External reference
Comparative resistance of the 20S and 26S proteasome to oxidative stress
10.1042/bj3350637 · 1998 · External reference
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress
10.1006/abbi.2000.1717 · 2000 · External reference
Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases
10.1016/s0021-9258(18)89731-9 · 1985 · External reference
Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy
10.1038/labinvest.3780222 · 2001 · External reference
Protein degradation and the generation of MHC class I-presented peptides
10.1016/s0065-2776(02)80012-8 · 2002 · External reference
Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats, and pigs of different ages
10.1016/s0047-6374(97)00093-6 · 1997 · External reference
4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease
10.1046/j.1471-4159.1997.68052092.x · 1997 · External reference
Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition
10.1016/s0014-5793(97)01391-4 · 1997 · External reference
Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells
10.1007/pl00000787 · 2001 · External reference
4-Hydroxynonenal inhibits Na(+)-K(+)-ATPase
10.1016/0891-5849(95)02041-1 · 1996 · External reference
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
10.1096/fj.14.11.1490 · 2000 · External reference
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts. Part II. Aging of nondividing cells
10.1096/fj.00-0210com · 2000 · External reference
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts. Part I. Effects of proliferative senescence
10.1096/fj.00-0209com · 2000 · External reference
Protein oxidation in aging and age-related diseases
10.1111/j.1749-6632.2001.tb05632.x · 2001 · External reference
Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome
10.1074/jbc.275.8.5565 · 2000 · External reference
The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor
10.1002/j.1460-2075.1996.tb00754.x · 1996 · External reference
Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine
10.1016/s0021-9258(18)53699-1 · 1993 · External reference
Proteolysis free radicals and aging
10.1016/s0891-5849(02)00837-7 · 2002 · External reference
Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination
10.1074/jbc.m001555200 · 2000 · External reference
The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
10.1159/000213753 · 1995 · External reference
Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis
10.1016/s0047-6374(98)00073-6 · 1998 · External reference
Lipofuscin: mechanisms of formation and increase with age
10.1111/j.1699-0463.1998.tb01346.x · 1998 · External reference
On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
10.1016/s0047-6374(97)00129-2 · 1998 · External reference
Proteasome inhibition enhances lipofuscin formation
10.1111/j.1749-6632.2002.tb04657.x · 2002 · External reference
Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
10.1016/s0531-5565(99)00045-5 · 1999 · External reference
The reaction of 4-hydroxy-2-nonenal with N alpha-acetyl-l-histidine
10.1016/0891-5849(95)00009-m · 1995 · External reference
Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine
10.1073/pnas.95.14.7975 · 1998 · External reference
Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction
10.1016/s0021-9258(18)53264-6 · 1993 · External reference
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes
10.1073/pnas.90.18.8742 · 1993 · External reference
Mechanisms of life span determination in Caenorhabditis elegans
10.1016/s0197-4580(99)00087-1 · 1999 · External reference
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal
10.1074/jbc.m110913200 · 2002 · External reference
Phosphate transport in rat liver mitochondria energy-dependent accumulation of phosphate by inverted inner membrane vesicles
10.1016/s0021-9258(17)34334-x · 1978 · External reference
Structural basis for the activation of 20S proteasomes by 11S regulators
10.1038/35040607 · 2000 · External reference
Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins
10.1016/s0891-5849(00)00423-8 · 2000 · External reference
Oxidative damage during aging targets mitochondrial aconitase
10.1073/pnas.94.21.11168 · 1997 · External reference
Structural and functional characterizations of the proteasome-activating protein PA26 from Trypanosoma brucei
10.1074/jbc.274.48.33921 · 1999 · External reference
Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores
10.1016/0891-5849(96)00175-x · 1996 · External reference
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
10.1073/pnas.93.7.2696 · 1996 · External reference
Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload
10.1016/s0891-5849(98)00312-8 · 1999 · External reference
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle
10.1096/fj.99-0881com · 2000 · External reference
Measurement and characterization of postischemic free radical generation in the isolated perfused heart
10.1016/s0021-9258(19)47240-2 · 1989 · External reference