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P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein

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Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2

10.1007/s00401-002-0528-6 · 2002 · External reference

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

10.1006/bbrc.1998.9246 · 1998 · External reference

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

10.1128/mcb.20.12.4474-4481.2000 · 2000 · External reference

Signal convergence on protein kinase A as a molecular correlate of learning

10.1073/pnas.88.13.5832 · 1991 · External reference

Age-dependent degradation of calpastatin in kidney of hypertensive rats

10.1074/jbc.m101936200 · 2001 · External reference

Involvement of calpain in diamide-induced cataract in cultured lenses

10.1016/0014-5793(92)80703-j · 1992 · External reference

Calpain II in two in vivo models of sugar cataract

10.1016/0014-4835(90)90151-j · 1990 · External reference

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

10.1172/jci10665 · 2000 · External reference

The Calpain Hypothesis of Neurodegeneration: Evidence for a Common Cytotoxic Pathway

10.1177/107385849700300513 · 1997 · External reference

10.1385/jmn:20:3:357

10.1385/jmn:20:3:357 · External reference

Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging

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Changes in brain protease activity in aging

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Is the senescent heart overloaded and already failing

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Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures

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Tau protein isoforms

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Calpain: a protease in search of a function

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Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

10.1074/jbc.m103701200 · 2001 · External reference

Calpain and mitochondria in ischemia/reperfusion injury

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Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson’s disease

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Age-related decline in chaperone-mediated autophagy

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When lysosomes get old

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Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract

10.1016/0925-4439(92)90136-b · 1992 · External reference

Autolysis, Ca2+ requirement, and heterodimer stability in m-calpain

10.1074/jbc.272.17.11268 · 1997 · External reference

Protein degradation by the proteasome and its implications in aging

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Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members

10.1074/jbc.m202945200 · 2002 · External reference

Subcellular localization and in vivo subunit interactions of ubiquitous μ-calpain

10.1074/jbc.m208657200 · 2003 · External reference

Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

10.1074/jbc.275.4.2390 · 2000 · External reference

Cutting to the chase: calpain proteases in cell motility

10.1016/s0962-8924(01)02179-1 · 2002 · External reference

Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin

10.1002/bies.950140810 · 1992 · External reference

Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-glycosidases including human lactase/phlorizin hydrolase

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Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system

10.1002/(sici)1097-4547(19970501)48:3<181::aid-jnr1>3.0.co;2-b · 1997 · External reference

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer’s disease

10.1016/s0006-8993(97)00384-3 · 1997 · External reference

A neutral calcium-activated proteinase from the soluble fraction of rat brain

10.1016/s0021-9258(18)51762-2 · 1964 · External reference

Limited autolysis reduces the Ca2+ requirement of a smooth muscle Ca2+-activated protease

10.1016/s0021-9258(18)34244-3 · 1982 · External reference

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

10.1038/79876 · 2000 · External reference

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation

10.1093/emboj/18.24.6880 · 1999 · External reference

The calpain family and human disease

10.1016/s1471-4914(01)02049-4 · 2001 · External reference

Calpain from rat intestinal epithelial cells: age-dependent dynamics during cell differentiation

10.1007/bf01075724 · 1994 · External reference

Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR)

10.1076/ceyr.25.4.207.13486 · 2002 · External reference

Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture

10.1046/j.1471-4159.1997.68041612.x · 1997 · External reference

Unresolved reference

1992 · External reference

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

10.1016/s0306-4522(00)00067-1 · 2000 · External reference

Alpha-crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract

10.1016/s0021-9258(17)46704-4 · 1993 · External reference

Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats

10.1007/bf00968667 · 1990 · External reference

Cellular signaling pathways and cytoskeletal organization

10.1111/j.1749-6632.1996.tb34409.x · 1996 · External reference

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

10.1038/36285 · 1997 · External reference

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

10.1074/jbc.m907757199 · 2000 · External reference

Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

10.1074/jbc.275.22.17064 · 2000 · External reference

Molecular diversity in amino-terminal domains of human calpastatin by exon skipping

10.1016/s0021-9258(18)42463-5 · 1992 · External reference

p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons

10.1002/jnr.490350411 · 1993 · External reference

Unresolved reference

External reference

Lp82 is the dominant form of calpain in young mouse lens

10.1006/exer.1998.0625 · 1999 · External reference

Calpastatins: biochemical and molecular biological studies

1991 · External reference

Klotho protein deficiency leads to overactivation of mu-calpain

10.1074/jbc.m206033200 · 2002 · External reference

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

10.1074/jbc.m205208200 · 2002 · External reference

Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway

10.1074/jbc.m107948200 · 2002 · External reference

Interaction of human erythrocyte multicatalytic proteinase with polycations

10.1016/0167-4838(90)90142-3 · 1990 · External reference

Unresolved reference

1985 · External reference

Modulation of the calpain autoproteolysis by calpastatin and phospholipids

10.1006/bbrc.1996.1779 · 1996 · External reference

The calpain–calpastatin system in rheumatoid arthritis

10.1016/s0167-5699(96)30064-9 · 1996 · External reference

A Ca(2+) switch aligns the active site of calpain

10.1016/s0092-8674(02)00659-1 · 2002 · External reference

Increased M-calpain expression in the mesencephalon of patients with Parkinson’s disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death

10.1016/0306-4522(96)00100-5 · 1996 · External reference

Fragmentation of an endogenous inhibitor upon complex formation with high- and low-Ca2+-requiring forms of calcium-activated neutral proteases

10.1021/bi00428a007 · 1989 · External reference

Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells

10.1006/bbrc.2000.3070 · 2000 · External reference

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

10.1074/jbc.m212255200 · 2003 · External reference

Studies and perspectives of protein kinase C

10.1126/science.3014651 · 1986 · External reference

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer’s disease

10.1111/j.1749-6632.1994.tb44402.x · 1994 · External reference

Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging

10.1523/jneurosci.19-03-00906.1999 · 1999 · External reference

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

10.1038/45159 · 1999 · External reference

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

10.1074/jbc.m109645200 · 2002 · External reference

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors

10.1073/pnas.83.8.2758 · 1986 · External reference

Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate

10.1073/pnas.84.11.3604 · 1987 · External reference

Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A

10.1016/0092-8674(95)90368-2 · 1995 · External reference

Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain

10.1016/s0896-6273(03)00260-5 · 2003 · External reference

Calcium pump phosphoenzyme from young and old human red cells

10.1006/cbir.2002.0932 · 2002 · External reference

Positive regulation of mu-calpain action by polyphosphoinositides

10.1016/s0021-9258(18)35804-6 · 1992 · External reference

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

10.1073/pnas.90.7.2628 · 1993 · External reference

Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation

10.1523/jneurosci.23-04-01189.2003 · 2003 · External reference

Protein kinases and phosphorylation in neurologic disorders and cell death

1991 · External reference

Site-directed activation of calpain is promoted by a membrane-associated natural activator protein

10.1042/bj2900191 · 1993 · External reference

Calpain function in the modulation of signal transduction molecules

10.1515/bc.2001.090 · 2001 · External reference

Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets

10.1080/09537100050057620 · 2000 · External reference

Band 3 protein degradation by calpain is enhanced in erythrocytes of old people

10.1042/bj2750047 · 1991 · External reference

Calpastatin in erythrocytes of young and old individuals

10.1042/bj3040365 · 1994 · External reference

10.1074/jbc.m302833200

10.1074/jbc.m302833200 · External reference

Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C

10.1046/j.1471-4159.1995.65020517.x · 1995 · External reference

Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C

10.1046/j.1471-4159.1996.66041539.x · 1996 · External reference

Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64

1991 · External reference

Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain

10.1128/mcb.22.8.2716-2727.2002 · 2002 · External reference

Neuronal protein kinase signaling cascades and excitotoxic cell death

10.1111/j.1749-6632.2001.tb03606.x · 2001 · External reference

Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey

10.1046/j.1471-4159.2003.01541.x · 2003 · External reference

Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation

10.1016/s0014-5793(03)00361-2 · 2003 · External reference

Calpain inhibitors block Ca(2+)−induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons

10.1002/jnr.490390414 · 1994 · External reference

The structure of calpain

10.1093/oxfordjournals.jbchem.a002903 · 2001 · External reference

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

10.1074/jbc.m104479200 · 2002 · External reference

A novel aspect of calpain activation

10.1016/s0014-5793(98)00856-4 · 1998 · External reference

Autolysis of calcium-activated neutral protease of chicken skeletal muscle

10.1093/oxfordjournals.jbchem.a133656 · 1981 · External reference

Specific aspartyl and calpain proteases are required for neurodegeneration in C, elegans

10.1038/nature01108 · 2002 · External reference

Externalization of calpain (calcium-dependent neutral cysteine proteinase) in human arthritic cartilage

1999 · External reference

Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent protease

10.1021/bi00406a059 · 1988 · External reference

Trophic agents that prevent neuronal apoptosis activate calpain and down-regulate CaMKIV

10.1046/j.1471-4159.2002.00829.x · 2002 · External reference

Changes in intracellular localization of calpastatin during calpain activation

10.1042/0264-6021:3430467 · 1999 · External reference

Age-related changes in calpain II and calpastatin in rat lens

10.1016/s0014-4835(89)80026-0 · 1989 · External reference

10.1016/s0197-4580(04)80585-2

10.1016/s0197-4580(04)80585-2 · External reference

Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms

10.1111/j.1471-4159.1986.tb00718.x · 1986 · External reference

Calpain and caspase: can you tell the difference

10.1016/s0166-2236(99)01479-4 · 2000 · External reference

Bax cleavage is mediated by calpain during drug-induced apoptosis

10.1038/sj.onc.1202034 · 1998 · External reference

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

10.1126/science.270.5240.1326 · 1995 · External reference

Calcium-dependent cysteine proteinase (calpain) in human arthritic synovial joints

10.1002/art.1780351111 · 1992 · External reference

Limited proteolysis of bovine lens alpha-crystallin by calpain, a Ca2+-dependent cysteine proteinase, isolated from the same tissue

10.1016/0304-4165(84)90313-1 · 1984 · External reference