Research graph
References from Immunoproteasomes and immunosenescence. Local targets link to admitted publications; unresolved targets remain external evidence.
Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases
10.4049/jimmunol.162.4.2154 · 1999 · External reference
The free radical theory of aging matures
10.1152/physrev.1998.78.2.547 · 1998 · External reference
Protein oxidation in aging, disease, and oxidative stress
10.1074/jbc.272.33.20313 · 1997 · External reference
A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x · 2001 · External reference
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians
10.1016/s0531-5565(02)00137-7 · 2002 · External reference
Age-dependent declines in proteasome activity in the heart
10.1006/abbi.2001.2663 · 2002 · External reference
Impairment of proteasome structure and function in aging
10.1016/s1357-2725(02)00085-7 · 2002 · External reference
Impact of ageing on proteasome structure and function in human lymphocytes
2002 · External reference
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
10.1093/emboj/20.10.2357 · 2001 · External reference
Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens
10.1084/jem.193.11.1319 · 2001 · External reference
Fibroblast cultures from healthy centenarians have an active proteasome
10.1016/s0531-5565(00)00137-6 · 2000 · External reference
Avoiding proteasomal processing: the case of EBNA1
2002 · External reference
Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies
1995 · External reference
The age of cancer
10.1038/35041694 · 2000 · External reference
Proteasomes and proteasome inhibition in the central nervous system
10.1016/s0891-5849(01)00635-9 · 2001 · External reference
Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging
10.1182/blood.v95.9.2860.009k35_2860_2868 · 2000 · External reference
Selective degradation of oxidized calmodulin by the 20S proteasome
10.1074/jbc.m005356200 · 2001 · External reference
Serum IL-6 level and the development of disability in older persons
10.1111/j.1532-5415.1999.tb01583.x · 1999 · External reference
The immunology of exceptional individuals: the lesson of centenarians
10.1016/0167-5699(95)80064-6 · 1995 · External reference
Inflamm-aging: an evolutionary perspective on immunosenescence
10.1111/j.1749-6632.2000.tb06651.x · 2000 · External reference
The network and the remodeling theories of aging: historical background and new perspectives
10.1016/s0531-5565(00)00172-8 · 2000 · External reference
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
10.1016/s0264-410x(99)00513-7 · 2000 · External reference
Phenotype-dependent differences in proteasome subunit composition and cleavage specificity in B cell lines
10.4049/jimmunol.160.7.3281 · 1998 · External reference
Variations in proteasome subunit composition and enzymatic activity in B-lymphoma lines and normal B cells
10.1002/1097-0215(20001215)88:6<881::aid-ijc7>3.0.co;2-d · 2000 · External reference
Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex
10.1002/j.1460-2075.1994.tb06625.x · 1994 · External reference
Proteasome inhibitors reconstitute the presentation of cytotoxic T cell epitopes in Epstein-Barr virus-associated tumors
10.1002/ijc.10653 · 2002 · External reference
A gated channel into the proteasome core particle
10.1038/80992 · 2000 · External reference
The ubiquitin system
10.1146/annurev.biochem.67.1.425 · 1998 · External reference
Association of the large multifunctional proteasome (LMP2) gene with Graves’ disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501
10.1046/j.1365-2265.1999.00755.x · 1999 · External reference
Parkinson’s disease, pesticides and mitochondrial dysfunction
10.1016/s0166-2236(00)01789-6 · 2001 · External reference
Impaired proteasome function in Alzheimer’s disease
10.1046/j.1471-4159.2000.0750436.x · 2000 · External reference
10.4049/jimmunol.169.4.1984
10.4049/jimmunol.169.4.1984 · External reference
Antigen processing by the proteasome
10.1038/35056572 · 2001 · External reference
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model
10.1089/10430340252898993 · 2002 · External reference
The effect of the interferon-gamma-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context
10.1002/1521-4141(200205)32:5<1368::aid-immu1368>3.0.co;2-z · 2002 · External reference
Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells
10.1182/blood-2002-04-1240 · 2003 · External reference
Identification of a TAP-independent, immunoproteasome-dependent CD8+ T cell epitope in Epstein-Barr virus latent membrane protein 2
10.1128/jvi.77.4.2757-2761.2003 · 2003 · External reference
Gene expression profile of aging and its retardation by caloric restriction
10.1126/science.285.5432.1390 · 1999 · External reference
Gene-expression profile of the ageing brain in mice
10.1038/77046 · 2000 · External reference
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
10.1073/pnas.232308999 · 2002 · External reference
Oxidative modification of proteins during aging
10.1016/s0531-5565(01)00135-8 · 2001 · External reference
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
10.1038/sj.gene.6363827 · 2002 · External reference
Allele frequencies of +874T—A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians
10.1016/s0531-5565(01)00198-x · 2002 · External reference
A stochastic model for CD8(+) T cell dynamics in human immunosenescence: implications for survival and longevity
10.1006/jtbi.2001.2433 · 2001 · External reference
The LMP2 polymorphism is associated with susceptibility to acute anterior uveitis in HLA-B27 positive juvenile and adult Mexican subjects with ankylosing spondylitis
10.1136/ard.56.8.488 · 1997 · External reference
Chronic antigenic stress, immunosenescence and human survivorship over the three last centuries: heuristic value of a mathematical model
10.1016/s0047-6374(03)00022-8 · 2003 · External reference
NF-kappa B in neuronal plasticity and neurodegenerative disorders
10.1172/jci11916 · 2001 · External reference
Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells
10.1016/s0531-5565(01)00196-6 · 2002 · External reference
Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
10.1016/s1074-7613(00)80163-6 · 2000 · External reference
The −174 C/G locus affects in vitro/in vivo IL-6 production during aging
10.1016/s0531-5565(01)00197-8 · 2002 · External reference
Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells
10.1093/gerona/55.5.b220 · 2000 · External reference
Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality
10.1111/j.1749-6632.1988.tb35268.x · 1988 · External reference
10.1006/cimm.1998.1418
10.1006/cimm.1998.1418 · External reference
Degradation of cell proteins and the generation of MHC class I-presented peptides
10.1146/annurev.immunol.17.1.739 · 1999 · External reference
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
10.1016/s0092-8674(94)90462-6 · 1994 · External reference
The production of a new MAGE-3 peptide presented to cytolytic T lymphocytes by HLA-B40 requires the immunoproteasome
10.1084/jem.20011974 · 2002 · External reference
Ubiquitin proteasome pathway: implications and advances in cancer therapy
10.1016/s0960-7404(01)00018-4 · 2001 · External reference
10.1007/978-3-642-60100-2_5
10.1007/978-3-642-60100-2_5 · External reference
A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C
10.1046/j.1365-2893.2002.00365.x · 2002 · External reference
Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis
10.1136/ard.57.1.33 · 1998 · External reference
The 26S proteasome: a molecular machine designed for controlled proteolysis
10.1146/annurev.biochem.68.1.1015 · 1999 · External reference
Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival
10.1093/gerona/56.10.b432 · 2001 · External reference
