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References from Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans. Local targets link to admitted publications; unresolved targets remain external evidence.
Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer’s disease
10.1016/s0306-4522(00)00281-5 · 2000 · External reference
Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death
10.1093/oxfordjournals.jbchem.a003305 · 2002 · External reference
Regulation of lifespan by sensory perception in Caenorhabditis elegans
10.1038/45544 · 1999 · External reference
The worm in us—Caenorhabditis elegans as a model of human disease
10.1016/s0167-7799(01)01925-4 · 2002 · External reference
G alphas-induced neurodegeneration in Caenorhabditis elegans
10.1523/jneurosci.18-08-02871.1998 · 1998 · External reference
The versatility and universality of calcium signalling
10.1038/35036035 · 2000 · External reference
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
10.1046/j.1471-4159.2000.0741469.x · 2000 · External reference
Regionally selective changes in brain lysosomes occur in the transition from young adulthood to middle age in rats
10.1016/s0306-4522(00)00021-x · 2000 · External reference
Motoneuron morphological alterations before and after the onset of the disease in the wobbler mouse
10.1016/s0006-8993(01)03405-9 · 2002 · External reference
Quantitative measures of aging in the nematode Caenorhabditis elegans. I. Population and longitudinal studies of two behavioral parameters
10.1016/0047-6374(81)90136-6 · 1981 · External reference
Uncoupling to survive? The role of mitochondrial inefficiency in ageing
10.1016/s0531-5565(00)00135-2 · 2000 · External reference
Epithelial sodium channel related to proteins involved in neurodegeneration
10.1038/361467a0 · 1993 · External reference
Calcium signaling: a tale for all seasons
10.1073/pnas.032427999 · 2002 · External reference
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans
10.1038/345410a0 · 1990 · External reference
Degenerin similarities
10.1038/361504a0 · 1993 · External reference
Green fluorescent protein as a marker for gene expression
10.1126/science.8303295 · 1995 · External reference
Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1
10.1074/jbc.273.25.15418 · 1998 · External reference
Caspase and calpain substrates: roles in synaptic plasticity and cell death
10.1002/(sici)1097-4547(19991001)58:1<167::aid-jnr16>3.0.co;2-k · 1999 · External reference
Excitotoxic cell death
10.1002/neu.480230915 · 1992 · External reference
Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems
10.1023/a:1015236203379 · 2002 · External reference
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment
10.1523/jneurosci.19-07-02556.1999 · 1999 · External reference
The genetic association between cathepsin D and Alzheimer’s disease
10.1016/s0304-3940(00)01260-x · 2000 · External reference
Adaptation to oxidative stress in young, but not in mature or old, Caenorhabditis elegans
10.1016/0891-5849(94)00118-4 · 1995 · External reference
Lysosomal alterations in hypoxic and reoxygenated hearts. II. Immunohistochemical and biochemical changes in cathepsin D
1980 · External reference
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
10.1038/349588a0 · 1991 · External reference
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson’s disease
10.1002/(sici)1097-4547(19990715)57:2<195::aid-jnr5>3.0.co;2-p · 1999 · External reference
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
10.1073/pnas.0536856100 · 2003 · External reference
Movement as an index of vitality: comparing wild type and the age-1 mutant of Caenorhabditis elegans
10.1093/gerona/50a.5.b254 · 1995 · External reference
Genetic control of programmed cell death in the nematode C. elegans
10.1016/0092-8674(86)90004-8 · 1986 · External reference
Sudden death—epidemiological aspects
1986 · External reference
RNA-triggered gene silencing
10.1016/s0168-9525(99)01818-1 · 1999 · External reference
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
10.1016/0378-1119(90)90224-f · 1990 · External reference
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
10.1093/genetics/118.1.75 · 1988 · External reference
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
10.1093/geronj/43.4.b102 · 1988 · External reference
Nematode ageing: putting metabolic theories to the test
10.1016/s0960-9822(99)80387-x · 1999 · External reference
Defining wild-type life span in Caenorhabditis elegans
10.1093/gerona/55.5.b215 · 2000 · External reference
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer’s disease
10.1016/s0006-8993(97)00384-3 · 1997 · External reference
Genetic pathways that regulate ageing in model organisms
10.1038/35041700 · 2000 · External reference
Neuropathology of degenerative cell death in Caenorhabditis elegans
10.1523/jneurosci.17-03-01033.1997 · 1997 · External reference
Genetically targeted cell disruption in Caenorhabditis elegans
10.1073/pnas.94.24.13128 · 1997 · External reference
Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer’s disease cerebral cortex: selectivity of changes and possible correlation to pathological severity
10.1006/neur.1996.0024 · 1996 · External reference
Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans
10.1126/science.6857247 · 1983 · External reference
Molecular genetics of life span in C. elegans: how much does it teach us?
10.1016/s0168-9525(97)01299-7 · 1998 · External reference
The biochemistry of apoptosis
10.1038/35037710 · 2000 · External reference
Apoptosis: corralling the corpses
10.1016/s0092-8674(01)00219-7 · 2001 · External reference
Hsp70 and aging
10.1007/bf01923466 · 1994 · External reference
Oxygen-dependent perturbation of life span and aging rate in the nematode
10.1093/geronj/48.2.b57 · 1993 · External reference
The calpain family and human disease
10.1016/s1471-4914(01)02049-4 · 2001 · External reference
The effects of aging on gene expression in the hypothalamus and cortex of mice
10.1073/pnas.98.4.1930 · 2001 · External reference
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
10.1038/nature01278 · 2003 · External reference
Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer’s disease
10.1016/0197-4580(95)02004-7 · 1995 · External reference
A C. elegans mutant that lives twice as long as wild type
10.1038/366461a0 · 1993 · External reference
A gene expression map for Caenorhabditis elegans
10.1126/science.1061603 · 2001 · External reference
Calpain-dependent cleavage of cain/cabin 1 activates calcineurin to mediate calcium-triggered cell death
10.1073/pnas.152336999 · 2002 · External reference
Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span
10.1016/0047-6374(77)90043-4 · 1977 · External reference
Non-ageing developmental variant of Caenorhabditis elegans
10.1038/260523a0 · 1976 · External reference
An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration
10.1101/gad.11.12.1493 · 1997 · External reference
The genetics of caloric restriction in Caenorhabditis elegans
10.1073/pnas.95.22.13091 · 1998 · External reference
Aging and resistance to oxidative damage in Caenorhabditis elegans
10.1073/pnas.90.19.8905 · 1993 · External reference
Genes that regulate both development and longevity in Caenorhabditis elegans
10.1093/genetics/139.4.1567 · 1995 · External reference
The changing landscape of ischaemic brain injury mechanisms
10.1038/399a007 · 1999 · External reference
Gene-expression profile of the ageing brain in mice
10.1038/77046 · 2000 · External reference
Neurotoxicity induces cleavage of p35 to p25 by calpain
10.1038/35012636 · 2000 · External reference
Four deaths and a funeral: from caspases to alternative mechanisms
10.1038/35085008 · 2001 · External reference
Transgenic invertebrate models of age-associated neurodegenerative diseases
10.1016/s0047-6374(01)00291-3 · 2001 · External reference
Ischemic cell death in brain neurons
10.1152/physrev.1999.79.4.1431 · 1999 · External reference
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
10.1073/pnas.92.16.7540 · 1995 · External reference
High-throughput isolation of Caenorhabditis elegans deletion mutants
10.1101/gr.9.9.859 · 1999 · External reference
The molecular bases of Alzheimer’s disease and other neurodegenerative disorders
10.1016/s0188-4409(01)00316-2 · 2001 · External reference
Apoptosis, oncosis, and necrosis. An overview of cell death
1995 · External reference
Klotho protein deficiency leads to overactivation of mu-calpain
10.1074/jbc.m206033200 · 2002 · External reference
Proteolysis of fodrin (non-erythroid spectrin) during apoptosis
10.1074/jbc.270.12.6425 · 1995 · External reference
Genetic analysis of ageing: role of oxidative damage and environmental stresses
10.1038/ng0596-25 · 1996 · External reference
Increased immunoreactivity of brain spectrin in Alzheimer disease: a marker for synapse loss?
10.1016/0006-8993(90)90755-z · 1990 · External reference
Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death
10.1046/j.1471-4159.2002.01057.x · 2002 · External reference
Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences
10.1002/j.1460-2075.1991.tb04966.x · 1991 · External reference
Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging
10.1111/j.1749-6632.2000.tb06649.x · 2000 · External reference
Detection of deletions in the mitochondrial genome of Caenorhabditis elegans
10.1093/nar/22.6.1075 · 1994 · External reference
Extension of life-span with superoxide dismutase/catalase mimetics
10.1126/science.289.5484.1567 · 2000 · External reference
Proteolysis, caloric restriction and aging
10.1016/s0047-6374(01)00219-6 · 2001 · External reference
Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain
10.1016/0047-6374(95)01586-o · 1995 · External reference
Increased M-calpain expression in the mesencephalon of patients with Parkinson’s disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
10.1016/0306-4522(96)00100-5 · 1996 · External reference
Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue
10.1016/0197-4580(90)90009-o · 1990 · External reference
A “protease activation cascade” in the pathogenesis of Alzheimer’s disease
10.1111/j.1749-6632.2000.tb05570.x · 2000 · External reference
Alterations of superoxide dismutase iso-enzyme activity, content, and mRNA expression with aging in rat skeletal muscle
10.1016/0047-6374(95)01637-f · 1995 · External reference
Protein degradation in aged nematodes (Turbatrix aceti)
10.1016/0006-291x(79)91749-2 · 1979 · External reference
Intra-cellular protein synthesis, modifications and aging
10.1042/bst0241043 · 1996 · External reference
The effect of age on the protein degradation system in the nematode Turbatrix aceti
10.1016/0047-6374(79)90016-2 · 1979 · External reference
Senescence and the accumulation of abnormal proteins
10.1016/0921-8734(91)90016-5 · 1991 · External reference
Decline in protease activities with age in the nematode Caenorhabditis elegans
10.1016/0047-6374(88)90001-2 · 1988 · External reference
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery
10.3171/jns.1997.87.5.0752 · 1997 · External reference
Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2
10.1126/science.1072302 · 2002 · External reference
The effect of age on enolase turnover in the free-living nematode, Turbatrix aceti
10.1016/0003-9861(79)90619-2 · 1979 · External reference
Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C
10.1046/j.1471-4159.1996.66041539.x · 1996 · External reference
Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3
10.1101/gad.14.8.901 · 2000 · External reference
Structure and physiological function of calpains
10.1042/bj3280721 · 1997 · External reference
Protein modification in aging
10.1093/geronj/43.5.b112 · 1988 · External reference
Protein oxidation and aging
10.1126/science.1355616 · 1992 · External reference
Unresolved reference
External reference
Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons
10.1016/s0304-3940(02)00469-x · 2002 · External reference
Post embriyonic cell lineages of the nematode Caenorhabditis elegans
10.1016/0012-1606(77)90158-0 · 1977 · External reference
The embryonic cell lineage of the nematode Caenorhabditis elegans
10.1016/0012-1606(83)90201-4 · 1983 · External reference
Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?
10.1093/embo-reports/kvf138 · 2002 · External reference
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans
10.1038/nature01108 · 2002 · External reference
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intra-cellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane
10.1016/s0021-9258(18)63852-9 · 1989 · External reference
10.1006/rwgn.2001.0175
10.1006/rwgn.2001.0175 · External reference
Degenerins. At the core of the metazoan mechanotransducer?
10.1111/j.1749-6632.2001.tb03664.x · 2001 · External reference
Caloric restriction and lifespan: a role for protein turnover?
10.1016/s0047-6374(01)00341-4 · 2002 · External reference
Toxic proteins in neurodegenerative disease
10.1126/science.1067122 · 2002 · External reference
Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1
10.1074/jbc.m000956200 · 2000 · External reference
10.1126/science.282.5396.2012
10.1126/science.282.5396.2012 · External reference
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
10.1016/0896-6273(95)90231-7 · 1995 · External reference
Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
10.1073/pnas.96.20.11399 · 1999 · External reference
Broad oxygen tolerance in the nematode Caenorhabditis elegans
10.1242/jeb.203.16.2467 · 2000 · External reference
The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states
10.1046/j.1365-2613.2000.00169.x · 2000 · External reference
Mechanisms of life span determination in Caenorhabditis elegans
10.1016/s0197-4580(99)00087-1 · 1999 · External reference
The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans
10.1096/fasebj.9.13.7557026 · 1995 · External reference
Age-specific modulation of light production potential, and alkaline phosphatase and protein tyrosine kinase activities in various age mutants of Caenorhabditis elegans
10.1093/gerona/53a.5.b380 · 1998 · External reference
Dark neurons in the ageing cerebellum: their mode of formation and effect of Maharishi Amrit Kalash
10.1023/a:1021303415191 · 2002 · External reference
The relentless effects of the aging process on protein turnover
10.1023/a:1010076818119 · 2000 · External reference
The structure of the ventral nerve cord of Caenorhabditis elegans
10.1098/rstb.1976.0086 · 1976 · External reference
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum
10.1016/s0896-6273(01)00432-9 · 2001 · External reference
Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
10.1016/s0301-0082(00)00006-x · 2000 · External reference
Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition
10.1007/s00401-002-0554-4 · 2002 · External reference
Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism
10.1002/(sici)1097-4547(19990915)57:6<830::aid-jnr8>3.0.co;2-2 · 1999 · External reference