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References from Icariin enhances PINK1-associated mitophagy to attenuate NLRP3/GSDMD-related microglial pyroptosis and cognitive impairment in Alzheimer's disease. Local targets link to admitted publications; unresolved targets remain external evidence.
New insights into atypical Alzheimer’s disease in the era of biomarkers
10.1016/s1474-4422(20)30440-3 · 2021 · External reference
2024 Alzheimer’s disease facts and figures
10.1002/alz.13809 · 2024 · External reference
The China Alzheimer report 2022
10.1136/gpsych-2022-100751 · 2022 · External reference
Alzheimer’s disease: clinical trials and drug development
10.1016/s1474-4422(10)70119-8 · 2010 · External reference
Neuroinflammation in Alzheimer’s disease: current evidence and future directions
10.1016/j.jalz.2016.02.010 · 2016 · External reference
Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
10.1186/s12974-022-02565-0 · 2022 · External reference
Microglial immune checkpoint mechanisms
10.1038/s41593-018-0145-x · 2018 · External reference
Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
10.1186/s12974-017-0972-9 · 2017 · External reference
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread
10.1016/j.cell.2023.11.029 · 2023 · External reference
The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease
10.1016/j.arr.2020.101192 · 2020 · External reference
NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice
10.1038/nature11729 · 2013 · External reference
NLRP3 inflammasome activation drives tau pathology
10.1038/s41586-019-1769-z · 2019 · External reference
Targeting NLRP3 inflammasome for neurodegenerative disorders
10.1038/s41380-023-02239-0 · 2023 · External reference
Pyroptosis: host cell death and inflammation
10.1038/nrmicro2070 · 2009 · External reference
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
10.1038/s41586-018-0372-z · 2018 · External reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · 2012 · External reference
Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
10.1093/jmcb/mjz020 · 2019 · External reference
Mitochondrial dysfunction in neurodegenerative disorders
10.1016/j.neurot.2023.10.002 · 2023 · External reference
Impact of icariin and its derivatives on inflammatory diseases and relevant signaling pathways
10.1016/j.intimp.2022.108861 · 2022 · External reference
A tri-compound formula comprising ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model
10.1016/j.phymed.2025.156737 · 2025 · External reference
Anti-Alzheimers molecular mechanism of icariin: insights from gut microbiota, metabolomics, and network pharmacology
10.1186/s12967-023-04137-z · 2023 · External reference
Anti-inflammatory effects of icariin in the acute and chronic phases of the mouse pilocarpine model of epilepsy
10.1016/j.ejphar.2023.176141 · 2023 · External reference
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
10.1016/j.neuint.2024.105705 · 2024 · External reference
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function
10.1016/j.jep.2025.120036 · 2025 · External reference
Adverse effects of Aβ1-42 oligomers: impaired contextual memory and altered intrinsic properties of CA1 pyramidal neurons
10.3390/biom14111425 · 2024 · External reference
Targeting ceramide-induced microglial pyroptosis: icariin is a promising therapy for Alzheimer’s disease
10.1016/j.jpha.2024.101106 · 2025 · External reference
Assessing nest building in mice
10.1038/nprot.2006.170 · 2006 · External reference
Novel object recognition and object location behavioral testing in mice on a budget
2018 · External reference
Use of the open field maze to measure locomotor and anxiety-like behavior in mice
2015 · External reference
The Y-Maze for Assessment of Spatial Working and Reference Memory in Mice
2019 · External reference
Pharmacology of anxiety or pharmacology of elevated plus maze?
10.1016/j.biopsych.2020.11.026 · 2021 · External reference
Morris water maze: procedures for assessing spatial and related forms of learning and memory
10.1038/nprot.2006.116 · 2006 · External reference
Microglia in neurodegeneration
10.1038/s41593-018-0242-x · 2018 · External reference
Gasdermins: effectors of pyroptosis
10.1016/j.tcb.2017.05.005 · 2017 · External reference
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson’s disease: involvement of PI3K/Akt and MEK/ERK signaling pathways
10.1016/j.phymed.2016.12.017 · 2017 · External reference
Salidroside ameliorates Alzheimer’s disease by targeting NLRP3 inflammasome-mediated pyroptosis
10.3389/fnagi.2021.809433 · 2022 · External reference
Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons
10.1007/s00401-022-02528-y · 2023 · External reference
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
10.1038/s41593-018-0332-9 · 2019 · External reference
Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: current insights and future directions
10.1016/j.arr.2024.102577 · 2024 · External reference
Donepezil regulates LPS and Aβ-stimulated neuroinflammation through MAPK/NLRP3 inflammasome/STAT3 signaling
10.3390/ijms221910637 · 2021 · External reference
Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer’s disease
10.1016/j.phymed.2023.154890 · 2023 · External reference
Icariin, an up-and-coming bioactive compound against neurological diseases: network pharmacology-based study and literature review
10.2147/dddt.s310686 · 2021 · External reference
Regulatory mechanism of icariin in cardiovascular and neurological diseases
10.1016/j.biopha.2022.114156 · 2023 · External reference
Icariin-Curcumol promotes docetaxel sensitivity in prostate cancer through modulation of the PI3K-Akt signaling pathway and the Warburg effect
10.1186/s12935-023-03042-1 · 2023 · External reference
Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-κB signaling pathways
10.1016/j.biopha.2019.109567 · 2019 · External reference
Targeting the NLRP3 inflammasome in inflammatory diseases
10.1038/nrd.2018.97 · 2018 · External reference
