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References from Single-cell analysis reveals synergistic therapeutic mechanisms of Shenqi Fuzheng formula against acute myocardial infarction. Local targets link to admitted publications; unresolved targets remain external evidence.
Identification of chemical constituents and blood-absorbed components of Shenqi Fuzheng extract based on UPLC-Triple-TOF/MS technology
2024 · External reference
Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng
10.1016/j.jep.2018.08.029 · 2018 · External reference
In vitro assays suggest Shenqi Fuzheng Injection has the potential to alter melanoma immune microenvironment
10.1016/j.jep.2016.08.038 · 2016 · External reference
Shenqi Fuzheng Injection reduces cisplatin-induced kidney injury via cGAS/STING signaling pathway in breast cancer mice model
2024 · External reference
Shenqi Fuzheng injection facilitates skeletal muscle mitophagy mediated by the ubiquitination of HIF‐1α to ameliorate cancer‐associated fatigue
10.1111/jcmm.18455 · 2024 · External reference
Observation on the efficacy of Shenqi Fuzheng Injection in treating senile heart failure after acute myocardial infarction
2016 · External reference
Clinic observation of 55 cases with chronic heart failure treated by shenqi fuzheng injection
2006 · External reference
Effect of shenqi fuzheng injection on peripheral blood ANGII, ET-1 levels and clinical curative effect in patients with congestive heart failure
2015 · External reference
Effects of Shenqi Fuzheng Injection on plasma N terminal pro-brain natriuretic peptide in patients with chronic heart failure
2011 · External reference
Heart disease and stroke statistics—2023 update: a report from the American heart association
10.1161/cir.0000000000001123 · 2023 · External reference
Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
10.1016/s0140-6736(19)30427-1 · 2019 · External reference
Inflammation, autophagy, and apoptosis after myocardial infarction
10.1161/jaha.117.008024 · 2018 · External reference
Single-cell RNA sequencing analysis reveals a crucial role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) cardiac fibroblasts after myocardial infarction
10.1161/circulationaha.119.044557 · 2020 · External reference
Prevalence and adverse outcomes of frailty in older patients with acute myocardial infarction after percutaneous coronary interventions: a systematic review and meta‐analysis
10.1002/clc.23929 · 2022 · External reference
Trends in the cost-effectiveness level of percutaneous coronary intervention: macro socioeconomic analysis and health technology assessment
10.1016/j.jjcc.2022.09.011 · 2023 · External reference
Non-vitamin-K-antagonist oral anticoagulants (NOACs) after acute myocardial infarction: a network meta-analysis
2024 · External reference
Single-cell omics reveal the mechanisms of traditional Chinese medicines
10.1016/j.phymed.2025.157204 · 2025 · External reference
Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali
10.1111/j.1742-7843.2004.t01-1-pto950508.x · 2004 · External reference
Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry
10.1007/bf03190631 · 2005 · External reference
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
10.1002/ijc.23131 · 2008 · External reference
Analysis of drug combinations: current methodological landscape
2015 · External reference
Applying synergy metrics to combination screening data: agreements, disagreements and pitfalls
10.1016/j.drudis.2019.09.002 · 2019 · External reference
CHD@ZJU: a knowledgebase providing network-based research platform on coronary heart disease
10.1093/database/bat047 · 2013 · External reference
Identifying roles of Jun-Chen-Zuo-Shi component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology
10.1186/1749-8546-9-24 · 2014 · External reference
Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice
2021 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2023 · External reference
Majorbio Cloud 2024: update single-cell and multiomics workflows
10.1002/imt2.217 · 2024 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
10.1073/pnas.1504557112 · 2015 · External reference
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block
10.1152/ajpheart.00256.2017 · 2017 · External reference
The effect of Wenxin Keli on the mRNA expression profile of rabbits with myocardial infarction
10.1155/2016/2352614 · 2016 · External reference
Identifying genes related to acute myocardial infarction based on network control capability
10.3390/genes13071238 · 2022 · External reference
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction
10.1016/j.xcrm.2024.101795 · 2024 · External reference
Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction
10.1186/s10020-024-00856-1 · 2024 · External reference
Angiogenesis after acute myocardial infarction
10.1093/cvr/cvaa287 · 2021 · External reference
Single-cell sequencing of the healthy and diseased heart reveals cytoskeleton-associated protein 4 as a new modulator of fibroblasts activation
10.1161/circulationaha.117.030742 · 2018 · External reference
A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarction
10.1038/s41598-018-33020-x · 2018 · External reference
Tissue factor in atherosclerosis and atherothrombosis
10.1016/j.atherosclerosis.2020.06.003 · 2020 · External reference
Proteomics of urinary exosomes for discovering novel non-invasive biomarkers of acute myocardial infarction patients
10.1016/j.ijbiomac.2025.140427 · 2025 · External reference
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury
10.1093/cvr/cvq154 · 2010 · External reference
Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets
10.1186/s12967-024-05353-x · 2024 · External reference
Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury
10.7554/elife.43882 · 2019 · External reference
Cardiac fibroblast diversity
10.1146/annurev-physiol-021119-034527 · 2020 · External reference
Macrophages in cardiac remodelling after myocardial infarction
10.1038/s41569-022-00823-5 · 2023 · External reference
Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts
10.1038/s41467-022-32284-2 · 2022 · External reference
Single-cell RNA sequencing reveals the temporal diversity and dynamics of cardiac immunity after myocardial infarction
10.1002/smtd.202100752 · 2022 · External reference
Direct reprogramming improves cardiac function and reverses fibrosis in chronic myocardial infarction
10.1161/circulationaha.121.058655 · 2023 · External reference
Resident fibroblast expansion during cardiac growth and remodeling
10.1016/j.yjmcc.2017.11.012 · 2018 · External reference
Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling
10.1038/nature11626 · 2012 · External reference
Spatially clustered type I interferon responses at injury borderzones
10.1038/s41586-024-07806-1 · 2024 · External reference
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction
10.1038/s41467-021-20905-1 · 2021 · External reference
Inflammatory cells during wound repair: the good, the bad and the ugly
10.1016/j.tcb.2005.09.002 · 2005 · External reference
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation
10.1016/j.immuni.2013.11.019 · 2014 · External reference
Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury
10.1161/circresaha.118.314028 · 2019 · External reference
Monocyte and macrophage plasticity in tissue repair and regeneration
10.1016/j.ajpath.2015.06.001 · 2015 · External reference
Pro-angiogenic macrophage phenotype to promote myocardial repair
10.1016/j.jacc.2019.03.503 · 2019 · External reference
Shexiang Tongxin Dropping Pills promote macrophage polarization-induced angiogenesis against coronary microvascular dysfunction via PI3K/Akt/mTORC1 pathway
10.3389/fphar.2022.840521 · 2022 · External reference
Redefining the identity of cardiac fibroblasts
10.1038/nrcardio.2017.57 · 2017 · External reference
Mechanisms of fibroblast activation in the remodeling myocardium
10.1007/s40139-017-0132-z · 2017 · External reference
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
10.1172/jci98215 · 2018 · External reference
Infarct scar: a dynamic tissue
10.1016/s0008-6363(00)00032-8 · 2000 · External reference
The hippo kinases MST1/2 in cardiovascular and metabolic diseases: a promising therapeutic target option for pharmacotherapy
10.1016/j.apsb.2023.01.015 · 2023 · External reference
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway
10.1016/j.lfs.2019.04.040 · 2019 · External reference
The cardiovascular protective effect and mechanism of calycosin and its derivatives
2020 · External reference
Herbal extract from Codonopsis pilosula (Franch.) Nannf. enhances cardiogenic differentiation and improves the function of infarcted rat hearts
2021 · External reference
Multi-layered effects of Codonopsis Radix on the immune system
10.1097/hm9.0000000000000130 · 2024 · External reference