Research graph
References from Targeting senescence-associated fibrotic signatures identifies syringin as an effective modulator of the ATR/CHK1–p53 axis in idiopathic pulmonary fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
10.1146/annurev-pathol-042320-030240 · 2022 · External reference
Advances in the management of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis
10.1136/bmj-2021-066354 · 2022 · External reference
Precision medicine advances in idiopathic pulmonary fibrosis
10.1016/j.ebiom.2023.104766 · 2023 · External reference
Aging and lung disease
10.1146/annurev-physiol-021119-034610 · 2020 · External reference
Telomere-mediated lung disease
10.1152/physrev.00046.2021 · 2022 · External reference
Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
10.1111/jcmm.13855 · 2018 · External reference
Cellular senescence mediates fibrotic pulmonary disease
10.1038/ncomms14532 · 2017 · External reference
Alternative polyadenylation contributes to fibroblast senescence in pulmonary fibrosis
10.1111/acel.70179 · 2025 · External reference
Mitogen-activated protein kinase-activated protein kinase 2 inhibition attenuates fibroblast invasion and severe lung fibrosis
10.1165/rcmb.2018-0033oc · 2019 · External reference
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts
10.1183/13993003.02307-2021 · 2022 · External reference
Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner
10.1042/cs20191160 · 2020 · External reference
The Genotype-Tissue Expression (GTEx) project
10.1038/ng.2653 · 2013 · External reference
DiSignAtlas: an atlas of human and mouse disease signatures based on bulk and single-cell transcriptomics
10.1093/nar/gkad961 · 2024 · External reference
NCBI GEO: archive for functional genomics data sets–update
10.1093/nar/gks1193 · 2013 · External reference
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
10.1016/j.cels.2018.11.005 · 2019 · External reference
CENPA acts as a prognostic factor that relates to immune infiltrates in gliomas
10.3389/fneur.2022.1015221 · 2022 · External reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · 2024 · External reference
The core role of macrophages in hepatocellular carcinoma: the definition of molecular subtypes and the prognostic risk system
10.3389/fphar.2023.1228052 · 2023 · External reference
Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM
10.1093/bib/bbad027 · 2023 · External reference
HERB 2.0: an updated database integrating clinical and experimental evidence for traditional Chinese medicine.
10.1093/nar/gkae1037 · 2025 · External reference
Reconciling multiple connectivity scores for drug repurposing
10.1093/bib/bbab161 · 2021 · External reference
Network-based in silico drug efficacy screening
10.1038/ncomms10331 · 2016 · External reference
Viruses.STRING: a virus-host protein-protein interaction database
10.3390/v10100519 · 2018 · External reference
ADMETlab 2.0
10.1093/nar/gkab255 · 2021 · External reference
Exploring animal models that resemble idiopathic pulmonary fibrosis
10.3389/fmed.2017.00118 · 2017 · External reference
The protein data bank
10.1093/nar/28.1.235 · 2000 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading
10.1002/jcc.21334 · 2010 · External reference
LigPlot + : multiple ligand-protein interaction diagrams for drug discovery
10.1021/ci200227u · 2011 · External reference
Pulmonary fibrosis model of mice induced by different administration methods of bleomycin
10.1186/s12890-023-02349-z · 2023 · External reference
Hydroxyproline in animal metabolism, nutrition, and cell signaling
10.1007/s00726-021-03056-x · 2022 · External reference
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
10.1038/nrd.2017.170 · 2017 · External reference
The role of aging in idiopathic pulmonary fibrosis
10.1007/s00408-015-9729-3 · 2015 · External reference
Prognostic function and immunologic landscape of a predictive model based on five senescence-related genes in IPF bronchoalveolar lavage fluid
10.3390/biomedicines12061246 · 2024 · External reference
Universal markers of cellular and replicative senescence
10.37586/2949-4745-3-2024-121-130 · 2024 · External reference
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
10.1007/s00018-014-1666-4 · 2014 · External reference
Targeting the ATR-CHK1 axis in cancer therapy
10.3390/cancers9050041 · 2017 · External reference
Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice
10.3389/fmed.2025.1451056 · 2025 · External reference
Strategies targeting cellular senescence
10.1172/jci95149 · 2018 · External reference
Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients’ treatment
10.1038/s41514-024-00138-4 · 2024 · External reference
Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases
10.1042/cs20190249 · 2019 · External reference
