Research graph
References from Data mining and multi-omics profiling to reveal the mechanisms of cold/hot property of traditional Chinese medicine in Alzheimer's disease treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Application of metabolomics and network analysis to reveal the ameliorating effect of four typical “hot” property herbs on hypothyroidism rats
10.3389/fphar.2022.955905 · 2022 · External reference
Coptisine from Coptis chinensis exerts diverse beneficial properties: a concise review
10.1111/jcmm.14725 · 2019 · External reference
Multisolvent similarity measure of Chinese herbal medicine ingredients for cold–hot nature identification
10.1021/acs.jcim.9b00682 · 2019 · External reference
Integrate metabolomics strategy and target prediction to reveal the ameliorate effect of four typical 'cold’ property herbs on hyperthyroidism rats
10.1016/j.jep.2022.115772 · 2023 · External reference
Serotonin-mediated regulation of mitophagy in Alzheimer’s disease: mechanistic insights and therapeutic potential
10.1016/j.arr.2025.102957 · 2026 · External reference
Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise
10.1186/s40035-023-00364-y · 2023 · External reference
The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer’s biomarkers
10.1016/j.lfs.2019.116695 · 2019 · External reference
Yin/Yang associated differential responses to Psoralea corylifolia Linn in rat models: an integrated metabolomics and transcriptomics study
10.1186/s13020-023-00793-x · 2023 · External reference
Principles and strategies in cold/hot property studies of traditional Chinese medicine: an evolution from traditional theory to modern elucidation
10.1016/j.jpha.2025.101455 · 2025 · External reference
Analyze the application and mechanism of Traditional Chinese Medicine in chronic urticaria based on data mining and network pharmacology
10.1016/j.cjac.2025.100512 · 2025 · External reference
D-galactose and aluminium chloride induced rat model with cognitive impairments
10.1016/j.biopha.2018.04.152 · 2018 · External reference
Thymidine and 2′-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury
10.1016/j.abb.2022.109377 · 2022 · External reference
Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer’s disease mice
10.1016/j.biopha.2024.116190 · 2024 · External reference
Recent advancement in therapeutic strategies for Alzheimer’s disease: insights from clinical trials
10.1016/j.arr.2023.102113 · 2023 · External reference
Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer’s disease
10.1016/j.redox.2023.102848 · 2023 · External reference
Systems pharmacology approach uncovers the therapeutic mechanism of medicarpin against scopolamine-induced memory loss
10.1016/j.phymed.2021.153662 · 2021 · External reference
Metabolic dysfunction in Alzheimer’s disease: from basic neurobiology to clinical approaches
10.3233/jad-179911 · 2018 · External reference
SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
10.4161/epi.20733 · 2014 · External reference
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation
10.1016/j.cmet.2011.08.016 · 2011 · External reference
Brain energetics, mitochondria, and traumatic brain injury
10.1515/revneuro-2019-0086 · 2020 · External reference
Deregulated mitochondrial microRNAs in Alzheimer’s disease: focus on synapse and mitochondria
10.1016/j.arr.2021.101529 · 2022 · External reference
Artemisinin attenuated hydrogen peroxide (H2O2)-induced oxidative injury in SH-SY5Y and hippocampal neurons via the activation of AMPK Pathway
10.3390/ijms20112680 · 2019 · External reference
Adenosine signalling to astrocytes coordinates brain metabolism and function
10.1038/s41586-024-07611-w · 2024 · External reference
Glucose metabolism: s sweet relief of Alzheimer’s disease
10.1016/j.cub.2016.07.060 · 2016 · External reference
The cholinergic system, the adrenergic system and the neuropathology of Alzheimer’s disease
10.3390/ijms22031273 · 2021 · External reference
An overview of recent analysis and detection of acetylcholine
10.1016/j.ab.2021.114381 · 2021 · External reference
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia
10.1074/jbc.c500238200 · 2005 · External reference
Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging
10.1089/dna.2019.5347 · 2020 · External reference
Altered glucose metabolism in Alzheimer’s disease: role of mitochondrial dysfunction and oxidative stress
10.1016/j.freeradbiomed.2022.09.032 · 2022 · External reference
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases
10.1152/ajpendo.00330.2020 · 2021 · External reference
Differences in peripheral oxidative stress markers in Alzheimer’s disease, vascular dementia and mixed dementia patients
10.1111/ggi.12659 · 2015 · External reference
Metabolomics analysis for nitrite degradation by the metabolites of limosilactobacillus fermentum RC4
10.3390/foods11071009 · 2022 · External reference
Evidence of hippocampal astrogliosis and antioxidant imbalance after L-tyrosine chronic administration in rats
10.1007/s11011-019-00511-3 · 2019 · External reference
Arachidonic acid induces ARE/Nrf2-dependent heme oxygenase-1 transcription in rat brain astrocytes
10.1007/s12035-017-0590-7 · 2017 · External reference
Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation
10.1016/j.redox.2024.103096 · 2024 · External reference
Research advances in the treatment of Alzheimer’s disease with polysaccharides from traditional Chinese medicine
2017 · External reference
Advancing nanomaterial-based strategies for Alzheimer’s disease: a perspective
10.1021/jacsau.5c00002 · 2025 · External reference
β-Glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice
10.1186/s40168-020-00920-y · 2020 · External reference
Studies on the role of Rosa roxburghii Tratt quercetin in improving intestinal metabolism and the microbiome in mice with Alzheimer’s disease
10.1016/j.jff.2024.106046 · 2024 · External reference
Phyllanthus emblica L. polysaccharides ameliorate colitis via microbiota modulation and dual inhibition of the RAGE/NF-κB and MAPKs signaling pathways in rats
10.1016/j.ijbiomac.2023.129043 · 2024 · External reference
Quercetin ameliorates bone loss in OVX rats by modulating the intestinal flora-SCFAs-inflammatory signaling axis
10.1016/j.intimp.2024.112341 · 2024 · External reference
Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice
10.1016/j.fbio.2024.105066 · 2024 · External reference
Dioscoreae persimilis polysaccharide ameliorates DSS-induced ulcerative colitis in mice through modulation of microbiota composition
2023 · External reference
Metformin inhibits tumor growth and affects intestinal flora in diabetic tumor-bearing mice
10.1016/j.ejphar.2021.174605 · 2021 · External reference
Treatment of neuropsychiatric symptoms in Alzheimer’s disease with traditional Chinese medicine: an integrative medicine case report
10.1016/j.aimed.2024.08.008 · 2024 · External reference
Acorus tatarinowii Schott attenuates Alzheimer’s disease via neuronal ferroptosis inhibition: a synergistic network pharmacology and multi-omics profiling study
10.1016/j.jep.2025.120829 · 2026 · External reference
Pharmacology of polygala tenuifolia and its significance in traditional Chinese medicine
10.1016/j.prmcm.2023.100341 · 2024 · External reference
Panax ginseng: a modulator of amyloid, tau pathology, and cognitive function in Alzheimer’s disease
10.1016/j.jgr.2025.03.011 · 2025 · External reference
Myelin in Alzheimer’s disease: culprit or bystander?
10.1186/s40478-023-01554-5 · 2023 · External reference
The roles of microglia and astrocytes in phagocytosis and myelination: insights from the cuprizone model of multiple sclerosis
10.1002/glia.24148 · 2022 · External reference
