Research graph
References from Gypensapogenin I ameliorates liver fibrosis by targeting MST1, restoring Hippo pathway homeostasis, and inhibiting HSCs activation. Local targets link to admitted publications; unresolved targets remain external evidence.
The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis
10.3389/fphys.2015.00209 · 2015 · External reference
Burden of liver diseases in the world
10.1016/j.jhep.2018.09.014 · 2019 · External reference
MicroRNA-744/transforming growth factor β1 relationship regulates liver cirrhosis
10.1007/s12072-019-09993-w · 2019 · External reference
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
10.1038/ncomms3823 · 2013 · External reference
Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1 gamma aggravates liver fibrosis
2020 · External reference
Peroxisome proliferator-activated receptor γ induces a phenotypic switch from activated to quiescent hepatic stellate cells
10.1074/jbc.m310284200 · 2004 · External reference
Shutting off inflammation: a novel switch on hepatic stellate cells
10.1002/hep.28442 · 2016 · External reference
The Hippo pathway in liver homeostasis and pathophysiology
10.1146/annurev-pathol-030420-105050 · 2021 · External reference
The Hippo pathway: regulators and regulations
10.1101/gad.210773.112 · 2013 · External reference
YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis
10.1016/j.devcel.2017.08.002 · 2017 · External reference
Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues
10.1016/j.mam.2018.09.002 · 2019 · External reference
Research progress on plant resources, chemical constituents, and pharmacological effects of Gynostemma pentaphyllum
2019 · External reference
Research progress on the anticancer mechanism of isoflavone saponins
2019 · External reference
New advances in the study of chemical composition, pharmacological effects and application of isoflavones
2020 · External reference
Resveratrol inhibits hepatic stellate cell activation via the hippo pathway
10.1155/2021/3399357 · 2021 · External reference
PLIP 2025: introducing protein-protein interactions to the protein-ligand interaction profiler
10.1093/nar/gkaf361 · 2025 · External reference
Mechanisms of hepatic stellate cell activation
10.1038/nrgastro.2017.38 · 2017 · External reference
TGF-β signalling and liver disease
10.1111/febs.13665 · 2016 · External reference
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
10.1126/scitranslmed.aaf2304 · 2016 · External reference
Role of the Hippo pathway in fibrosis and cancer
10.3390/cells8050468 · 2019 · External reference
Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in hepatocyte TAZ/WWTR1
10.1016/j.cmet.2016.09.016 · 2016 · External reference
Elucidation of a universal size-control mechanism in Drosophila and mammals
10.1016/j.cell.2007.07.019 · 2007 · External reference
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma
10.1186/1476-4598-13-110 · 2014 · External reference
Exogenous S1P via S1P receptor 2 induces CTGF expression through Src-RhoA-ROCK-YAP pathway in hepatic stellate cells
10.1007/s11033-024-09868-w · 2024 · External reference
Pathogenesis of liver fibrosis
10.1146/annurev-pathol-011110-130246 · 2011 · External reference
Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum
10.1016/j.ejmech.2012.01.052 · 2012 · External reference
Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4
10.1172/jci121955 · 2019 · External reference
Omega-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation
10.1038/srep30029 · 2016 · External reference
Enhancement of functional insulin-producing cell differentiation from embryonic stem cells through MST1-silencing
10.1186/s13098-025-01666-z · 2025 · External reference
Direct activation of ATM by resveratrol under oxidizing conditions
10.1371/journal.pone.0097969 · 2014 · External reference
