Research graph
References from Monitoring of Doxorubicin-Mediated Mitochondria–Lysosome Crosstalk by In Situ Raman Spectroscopy: The Molecular Mechanism during Apoptosis and Implications for Cardiotoxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
10.1124/pr.56.2.6 · 2004 · External reference
ROCK2 increases drug resistance in acute myeloid leukemia via metabolic reprogramming and MAPK/PI3K/AKT signaling
10.1016/j.intimp.2024.112897 · 2024 · External reference
Development of Diffuse Large B-cell Lymphoma Serendipitously Led to Life-Saving Treatment in a Patient with Refractory Classical Hodgkin Lymphoma
10.2169/internalmedicine.4334-24 · 2025 · External reference
Anthracyclines in the treatment of early breast cancer friend or foe?
10.1016/j.breast.2022.06.007 · 2022 · External reference
Remodeling Gastric Carcinoma Cells to Reverse Drug Resistance and Increase Antitumor Effects by Co-Delivering Oleanolic Acid and Doxorubicin
2020 · External reference
Novel combination chemotherapy with topatecan, doxorubicin and vincristine (TAV) in patients with advanced lung cancer.
10.1200/jco.2004.22.90140.7251 · 2004 · External reference
Synthesis of Doxorubicin-Loaded Nanobubble and Its Effect on Targeted Therapy for Patients with Ovarian Cancer
10.1166/sam.2021.4031 · 2021 · External reference
MITO39: Efficacy and Tolerability of Pegylated Liposomal Doxorubicin (PLD)-Trabectedin in the Treatment of Relapsed Ovarian Cancer after Maintenance Therapy with PARP Inhibitors-A Multicenter Italian Trial in Ovarian Cancer Observational Case-Control Study
10.3390/cancers16010041 · 2024 · External reference
Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines
10.3892/ijo_00000137 · 2009 · External reference
Expression and biological significance of topoisomerase II α (TOP2A) in oral squamous cell carcinoma
10.1007/s12672-024-01295-4 · 2024 · External reference
Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy
10.1161/circresaha.119.314681 · 2020 · External reference
Anthracycline cardiotoxicity
10.1517/14740338.5.6.791 · 2006 · External reference
Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies
10.3390/biom14121614 · 2024 · External reference
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions
10.1093/jpp/rgac063 · 2022 · External reference
Functional role of cardiolipin in mitochondrial bioenergetics
10.1016/j.bbabio.2013.10.006 · 2014 · External reference
Role of cardiolipin alterations in mitochondrial dysfunction and disease
10.1152/ajpcell.00243.2006 · 2007 · External reference
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
10.1038/nchembio727 · 2005 · External reference
Cardiolipin nanodisks confer protection against doxorubicin-induced mitochondrial dysfunction
10.1016/j.bbamem.2022.183984 · 2022 · External reference
Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy
10.1186/s12964-023-01077-5 · 2023 · External reference
Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers
10.1016/s0005-2736(01)00371-6 · 2001 · External reference
Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates
10.1002/anie.201909638 · 2019 · External reference
Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
10.1194/jlr.m027557 · 2012 · External reference
Mitochondrial quality control as a therapeutic target in cardiovascular disease: Mechanistic insights and future directions
10.1515/jtim-2025-0030 · 2025 · External reference
Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification
10.1161/circulationaha.115.017443 · 2016 · External reference
Interaction of doxorubicin with polynucleotides. A spectroscopic study
10.1021/bi401687v · 2014 · External reference
Cardiolipin models for molecular simulations of bacterial and mitochondrial membranes
10.1021/ct300590v · 2013 · External reference
Regulation of membrane turnover by phosphatidic acid: cellular functions and disease implications
10.3389/fcell.2019.00083 · 2019 · External reference
Interaction of phospholipid dispersions with water-soluble porphyrins as monitored by their Raman temperature profiles
10.1016/j.chemphyslip.2004.06.002 · 2004 · External reference
Calorimetry-Derived Composition Vectors to Resolve Component Raman Spectra in Phospholipid Phase Transitions
10.1177/0003702816652359 · 2016 · External reference
DSC and Raman studies of the side chain length effect of ubiquinones on the thermotropic phase behavior of liposomes
10.1016/j.tca.2006.05.009 · 2006 · External reference
Low-Temperature Dynamical and Structural Properties of Saturated and Monounsaturated Phospholipid Bilayers Revealed by Raman and Spin-Label EPR Spectroscopy
10.1021/jp3038895 · 2012 · External reference
Structural determination of model phospholipid membranes by Raman spectroscopy: Laboratory experiment
10.1002/bmb.21603 · 2022 · External reference
Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects
10.3390/cells8070728 · 2019 · External reference
Cardiolipin stabilizes respiratory chain supercomplexes
10.1074/jbc.m308366200 · 2003 · External reference
Cardiolipin deficiency releases cytochrome from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis
10.1038/sj.cdd.4402020 · 2007 · External reference
Cytochrome c as a Peroxidase: Activation of the Precatalytic Native State by H2O2-Induced Covalent Modifications
10.1021/jacs.7b07106 · 2017 · External reference
Solution Structure of Oxidized Horse Heart Cytochrome c
10.1021/bi970724w · 1997 · External reference
Spectroscopic Characterization of Structural Changes of Cytochrome c upon Interaction with Cardiolipin
2003 · External reference
A Critical Evaluation of the Mechanisms of Action Proposed for the Antitumor Effects of the Anthracycline Antibiotics
10.1016/s0006-2952(98)00307-4 · 1999 · External reference
Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
10.1016/j.yjmcc.2012.03.006 · 2012 · External reference
DNA and its associated processes as targets for cancer therapy
10.1038/nrc749 · 2002 · External reference
Chemotherapy induced DNA damage response Convergence of drugs and pathways
10.4161/cbt.23761 · 2013 · External reference
Induction of apoptosis by cancer chemotherapy
10.1006/excr.2000.4838 · 2000 · External reference
Doxorubicin-An Agent with Multiple Mechanisms of Anticancer Activity
10.3390/cells12040659 · 2023 · External reference
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
10.1111/bph.12461 · 2014 · External reference
The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin
10.1681/asn.2012121216 · 2013 · External reference
Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells
10.3390/molecules201219764 · 2015 · External reference
Mitochondrial protein interaction landscape of SS-31
10.1073/pnas.2002250117 · 2020 · External reference
Cysteine cathepsins: From structure, function and regulation to new frontiers
10.1016/j.bbapap.2011.10.002 · 2012 · External reference
Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *
10.1074/jbc.m008944200 · 2001 · External reference
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
10.1038/nm.2919 · 2012 · External reference
Cardiac lipid metabolism, mitochondrial function, and heart failure
10.1093/cvr/cvad100 · 2023 · External reference
Autophagy in cardiac myocyte homeostasis, aging, and pathology
10.1016/j.cardiores.2005.08.014 · 2005 · External reference
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics
10.1016/j.canlet.2024.216662 · 2024 · External reference
Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates
10.1002/anie.201909638 · ExternalCitation · doi-reference
Structural determination of model phospholipid membranes by Raman spectroscopy: Laboratory experiment
10.1002/bmb.21603 · ExternalCitation · doi-reference
Induction of apoptosis by cancer chemotherapy
10.1006/excr.2000.4838 · ExternalCitation · doi-reference
Expression and biological significance of topoisomerase II α (TOP2A) in oral squamous cell carcinoma
10.1007/s12672-024-01295-4 · ExternalCitation · doi-reference
Functional role of cardiolipin in mitochondrial bioenergetics
10.1016/j.bbabio.2013.10.006 · ExternalCitation · doi-reference
Cardiolipin nanodisks confer protection against doxorubicin-induced mitochondrial dysfunction
10.1016/j.bbamem.2022.183984 · ExternalCitation · doi-reference
Cysteine cathepsins: From structure, function and regulation to new frontiers
10.1016/j.bbapap.2011.10.002 · ExternalCitation · doi-reference
Anthracyclines in the treatment of early breast cancer friend or foe?
10.1016/j.breast.2022.06.007 · ExternalCitation · doi-reference
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics
10.1016/j.canlet.2024.216662 · ExternalCitation · doi-reference
Autophagy in cardiac myocyte homeostasis, aging, and pathology
10.1016/j.cardiores.2005.08.014 · ExternalCitation · doi-reference
Interaction of phospholipid dispersions with water-soluble porphyrins as monitored by their Raman temperature profiles
10.1016/j.chemphyslip.2004.06.002 · ExternalCitation · doi-reference
ROCK2 increases drug resistance in acute myeloid leukemia via metabolic reprogramming and MAPK/PI3K/AKT signaling
10.1016/j.intimp.2024.112897 · ExternalCitation · doi-reference
DSC and Raman studies of the side chain length effect of ubiquinones on the thermotropic phase behavior of liposomes
10.1016/j.tca.2006.05.009 · ExternalCitation · doi-reference
Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
10.1016/j.yjmcc.2012.03.006 · ExternalCitation · doi-reference
Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers
10.1016/s0005-2736(01)00371-6 · ExternalCitation · doi-reference
A Critical Evaluation of the Mechanisms of Action Proposed for the Antitumor Effects of the Anthracycline Antibiotics
10.1016/s0006-2952(98)00307-4 · ExternalCitation · doi-reference
Interaction of doxorubicin with polynucleotides. A spectroscopic study
10.1021/bi401687v · ExternalCitation · doi-reference
Solution Structure of Oxidized Horse Heart Cytochrome c
10.1021/bi970724w · ExternalCitation · doi-reference
Cardiolipin models for molecular simulations of bacterial and mitochondrial membranes
10.1021/ct300590v · ExternalCitation · doi-reference
Cytochrome c as a Peroxidase: Activation of the Precatalytic Native State by H2O2-Induced Covalent Modifications
10.1021/jacs.7b07106 · ExternalCitation · doi-reference
Low-Temperature Dynamical and Structural Properties of Saturated and Monounsaturated Phospholipid Bilayers Revealed by Raman and Spin-Label EPR Spectroscopy
10.1021/jp3038895 · ExternalCitation · doi-reference
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
10.1038/nchembio727 · ExternalCitation · doi-reference
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
10.1038/nm.2919 · ExternalCitation · doi-reference
DNA and its associated processes as targets for cancer therapy
10.1038/nrc749 · ExternalCitation · doi-reference
Cardiolipin deficiency releases cytochrome from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis
10.1038/sj.cdd.4402020 · ExternalCitation · doi-reference
Mitochondrial protein interaction landscape of SS-31
10.1073/pnas.2002250117 · ExternalCitation · doi-reference
Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *
10.1074/jbc.m008944200 · ExternalCitation · doi-reference
Cardiolipin stabilizes respiratory chain supercomplexes
10.1074/jbc.m308366200 · ExternalCitation · doi-reference
Cardiac lipid metabolism, mitochondrial function, and heart failure
10.1093/cvr/cvad100 · ExternalCitation · doi-reference
Doxorubicin-induced cardiotoxicity: causative factors and possible interventions
10.1093/jpp/rgac063 · ExternalCitation · doi-reference
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics
10.1111/bph.12461 · ExternalCitation · doi-reference
Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
10.1124/pr.56.2.6 · ExternalCitation · doi-reference
Role of cardiolipin alterations in mitochondrial dysfunction and disease
10.1152/ajpcell.00243.2006 · ExternalCitation · doi-reference
Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy
10.1161/circresaha.119.314681 · ExternalCitation · doi-reference
Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification
10.1161/circulationaha.115.017443 · ExternalCitation · doi-reference
Synthesis of Doxorubicin-Loaded Nanobubble and Its Effect on Targeted Therapy for Patients with Ovarian Cancer
10.1166/sam.2021.4031 · ExternalCitation · doi-reference
Calorimetry-Derived Composition Vectors to Resolve Component Raman Spectra in Phospholipid Phase Transitions
10.1177/0003702816652359 · ExternalCitation · doi-reference
Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy
10.1186/s12964-023-01077-5 · ExternalCitation · doi-reference
Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
10.1194/jlr.m027557 · ExternalCitation · doi-reference
Novel combination chemotherapy with topatecan, doxorubicin and vincristine (TAV) in patients with advanced lung cancer.
10.1200/jco.2004.22.90140.7251 · ExternalCitation · doi-reference
Mitochondrial quality control as a therapeutic target in cardiovascular disease: Mechanistic insights and future directions
10.1515/jtim-2025-0030 · ExternalCitation · doi-reference
Anthracycline cardiotoxicity
10.1517/14740338.5.6.791 · ExternalCitation · doi-reference
The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin
10.1681/asn.2012121216 · ExternalCitation · doi-reference
Development of Diffuse Large B-cell Lymphoma Serendipitously Led to Life-Saving Treatment in a Patient with Refractory Classical Hodgkin Lymphoma
10.2169/internalmedicine.4334-24 · ExternalCitation · doi-reference
Regulation of membrane turnover by phosphatidic acid: cellular functions and disease implications
10.3389/fcell.2019.00083 · ExternalCitation · doi-reference
Mitophagy in Doxorubicin-Induced Cardiotoxicity: Insights into Molecular Biology and Novel Therapeutic Strategies
10.3390/biom14121614 · ExternalCitation · doi-reference
MITO39: Efficacy and Tolerability of Pegylated Liposomal Doxorubicin (PLD)-Trabectedin in the Treatment of Relapsed Ovarian Cancer after Maintenance Therapy with PARP Inhibitors-A Multicenter Italian Trial in Ovarian Cancer Observational Case-Control Study
10.3390/cancers16010041 · ExternalCitation · doi-reference
Doxorubicin-An Agent with Multiple Mechanisms of Anticancer Activity
10.3390/cells12040659 · ExternalCitation · doi-reference
Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects
10.3390/cells8070728 · ExternalCitation · doi-reference
Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells
10.3390/molecules201219764 · ExternalCitation · doi-reference
Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines
10.3892/ijo_00000137 · ExternalCitation · doi-reference
Chemotherapy induced DNA damage response Convergence of drugs and pathways
10.4161/cbt.23761 · ExternalCitation · doi-reference
